Associated Genetic Biomarkers
TP53 Y220C is present in 0.64% of AACR GENIE cases, with high grade ovarian serous adenocarcinoma, breast invasive ductal carcinoma, pancreatic adenocarcinoma, lung adenocarcinoma, and colon adenocarcinoma having the greatest prevalence .
TP53 Y220C serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains TP53 Y220C as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
Trials with TP53 Y220C in the inclusion eligibility criteria most commonly target malignant solid tumor .
Pc14586 is the most frequent therapy in trials with TP53 Y220C as an inclusion criteria .
Significance of TP53 Y220C in Diseases
Malignant Solid Tumor +
TP53 is altered in 43.65% of malignant solid tumor patients with TP53 Y220C present in 0.65% of all malignant solid tumor patients .
TP53 Y220C is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains TP53 Y220C and malignant solid tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
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