Associated Genetic Biomarkers
TYRO3 Mutation is present in 2.37% of AACR GENIE cases, with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, oligodendroglioma, and ovarian serous adenocarcinoma having the greatest prevalence .
TYRO3 Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains TYRO3 Mutation as an inclusion criterion, 1 is phase 2 (1 open).
Trials with TYRO3 Mutation in the inclusion eligibility criteria most commonly target malignant solid tumor .
Cabozantinib is the most frequent therapy in trials with TYRO3 Mutation as an inclusion criteria .
Significance of TYRO3 Mutation in Diseases
Malignant Solid Tumor +
TYRO3 is altered in 0.04% of malignant solid tumor patients with TYRO3 Mutation present in 2.47% of all malignant solid tumor patients .
TYRO3 Mutation is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains TYRO3 Mutation and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.