Associated Genetic Biomarkers
XRCC2 Mutation is present in 0.35% of AACR GENIE cases, with colon adenocarcinoma, lung adenocarcinoma, melanoma, bladder urothelial carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence .
XRCC2 Mutation serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain XRCC2 Mutation as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
Trials with XRCC2 Mutation in the inclusion eligibility criteria most commonly target malignant solid tumor and urothelial carcinoma .
Olaparib, copanlisib, and durvalumab are the most frequent therapies in trials with XRCC2 Mutation as an inclusion criteria .
Significance of XRCC2 Mutation in Diseases
Urothelial Carcinoma +
XRCC2 is altered in 0.9% of urothelial carcinoma patients with XRCC2 Mutation present in 0.9% of all urothelial carcinoma patients .
XRCC2 Mutation is an inclusion criterion in 1 clinical trial for urothelial carcinoma, of which 1 is open and 0 are closed. Of the trial that contains XRCC2 Mutation and urothelial carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Malignant Solid Tumor +
XRCC2 is altered in 0.46% of malignant solid tumor patients with XRCC2 Mutation present in 0.35% of all malignant solid tumor patients .
XRCC2 Mutation is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains XRCC2 Mutation and malignant solid tumor as inclusion criteria, 1 is phase 1 (1 open) .
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