Associated Genetic Biomarkers
XRCC6 Mutation is present in 0.98% of AACR GENIE cases, with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, lung adenocarcinoma, melanoma, and bladder urothelial carcinoma having the greatest prevalence .
XRCC6 Mutation serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain XRCC6 Mutation as an inclusion criterion, 2 are phase 2 (2 open).
Trials with XRCC6 Mutation in the inclusion eligibility criteria most commonly target melanoma and urothelial carcinoma .
Nivolumab, olaparib, and talazoparib are the most frequent therapies in trials with XRCC6 Mutation as an inclusion criteria .
Significance of XRCC6 Mutation in Diseases
XRCC6 is altered in 4.23% of melanoma patients with XRCC6 Mutation present in 2.72% of all melanoma patients .
XRCC6 Mutation is an inclusion criterion in 1 clinical trial for melanoma, of which 1 is open and 0 are closed. Of the trial that contains XRCC6 Mutation and melanoma as inclusion criteria, 1 is phase 2 (1 open) .
Urothelial Carcinoma +
XRCC6 is altered in 2.44% of urothelial carcinoma patients with XRCC6 Mutation present in 2.44% of all urothelial carcinoma patients .
XRCC6 Mutation is an inclusion criterion in 1 clinical trial for urothelial carcinoma, of which 1 is open and 0 are closed. Of the trial that contains XRCC6 Mutation and urothelial carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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