Inclusion Criteria:

          -  Advanced metastatic or unresectable malignancy that is refractory to standard therapy
             and/or existing therapies are not likely to achieve clinical benefit, and/or the
             patient declines to receive standard treatment such as chemotherapy.

          -  Evaluable disease;

          -  Last dose of prior chemotherapy, radiation therapy, or investigational agents occurred
             at least 4 weeks before the start of therapy;

          -  Recovery from the adverse effects ≤ grade 1;

          -  Acceptable ECOG status 0, 1, or 2;

          -  Life expectancy greater than 3 months following study entry;

          -  Adequate laboratory values;

          -  For patients enrolling in the four expansion cohorts:

               -  NSCLC patients must meet criteria for MET and/or Axl expression or,

               -  HNSCC patients must meet criteria for MET and/or Axl expression or,

               -  NSCLC patients must meet criteria for amplification of the MET gene locus,
                  defined MET mutations, or rearrangements involving the AXL or MET gene locus or;

               -  Patients with tumor types such as HNSCC, papillary renal carcinoma, gastric
                  adenocarcinoma, and other solid tumors must meet criteria for amplification of
                  the MET gene locus, defined MET mutations, or rearrangements involving the AXL or
                  MET gene locus

        Exclusion Criteria:

          -  Uncontrolled concurrent illness;

          -  History of cardiovascular illness;

          -  QTc > 470 msec (including subjects on medication);

          -  Left ventricular ejection fraction (LVEF) < 50%;

          -  Immunocompromised subjects;

          -  History of bone marrow transplant;

          -  Lung tumor lesions with increased likelihood of bleeding;

          -  Symptomatic or uncontrolled brain metastases;

          -  Unable to swallow oral medications or with pre-existing gastrointestinal disorders.