Inclusion Criteria:

          -  Patients must have a histologic or cytologic diagnosis of epithelial ovarian cancer

          -  Patients are eligible if they have failed to enter a complete remission after therapy
             and are not eligible for otherwise curative therapy

          -  Patients must not have received any antineoplastic chemotherapy or immunotherapy for
             the four weeks preceding tumor excision; six weeks for nitrosoureas and mitomycin-C

          -  Patients must not have received irradiation for the four weeks prior to removal of the
             tumor and no previously irradiated tumor deposits may be used for tumor lysate in the
             development of the dendritic cell vaccine

          -  Age >18 years. Because no dosing or adverse event data are currently available on the
             use of dendritic cell vaccination in patients <18 years of age, children are excluded
             from this study but may be eligible for future pediatric phase 2 combination trials

          -  Life expectancy of greater than three months

          -  Karnofsky performance status must be >70%; (see appendix A)

          -  Patients must have adequate baseline hematopoetic function as defined below. - The
             following labs must be drawn within four weeks of having the tumor harvested and/or
             receiving the vaccine

               -  total white blood cell count > 2,500/mm3

               -  absolute neutrophil count > 1,000/mm3

               -  absolute lymphocyte count > 500/mm3

               -  platelet count > 80,000/mm3

          -  Patients must have adequate baseline organ function as defined below. The following
             labs must be drawn within four weeks of having the tumor harvested and/or receiving
             the vaccine:

               -  total bilirubin ≤ 2.0 mg/dl

               -  AST(SGOT)/ALT(SGPT) <2.5 X institutional upper limit of normal

               -  creatinine ≤2.0 mg/dl

               -  prothrombin time (INR) ≤1.5 X institutional upper limit of normal

               -  albumin >3.0 mg/dl

          -  If patients have had recent surgery, then they must be fully recovered from the
             effects of that surgery.

          -  The effects of the vaccine on the developing human fetus at the recommended
             therapeutic dose are unknown. Women of child-bearing potential must agree to use
             adequate contraception (hormonal or barrier method of birth control; abstinence) prior
             to study entry and for the duration of study participation. Should a woman become
             pregnant or suspect she is pregnant while participating in this study, she should
             inform her treating physician immediately.

          -  Patients must have the ability to understand and the willingness to sign a written
             informed consent document.

        Additional eligibility requirements for vaccine therapy initiation:

          -  Patients are eligible after tumor collection for the vaccine strategy, or for those
             selected to receive ONTAK alone (group 3 -CLOSED) because tumor is not available can
             enroll at ay time they fulfill the Eligibility Criteria. Pre-vaccination the goal is
             to establish a Minimal Residual Disease state (MRD maximum tumor diameter of any
             residual disease ≤ 1cm). This can be achieved with surgery and/or salvage
             chemotherapy. Vaccine administration and/or vaccine therapy will commence at least 4
             weeks after the completion of the last day of any of the aforementioned therapies

          -  Patients to be randomized to groups 1 and 2 must have tumor available for preparation
             of tumor lysate vaccine

          -  Women and members of all races and ethnic groups are eligible for this trial

        Exclusion Criteria:

          -  Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for
             nitrosoureas or mitomycin C) prior to entering the study or those who have not
             recovered from adverse events due to agents administered more than 4 weeks earlier

          -  Patients may not be receiving any other investigational agents.

          -  Patients who have received prior anti-tumor vaccines are ineligible

          -  History of allergic reactions attributed to compounds of similar chemical or biologic
             composition to monocolonal antibodies from Murine sources

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, active bleeding, symptomatic congestive heart failure, unstable angina
             pectoris, cardiac arrhythmia, uncontrolled bronchospasm, hypertension, hyperglycemia,
             or hypercalcemia; or psychiatric illness/social situations that in the opinion of the
             investigators would compromise the patient's ability to tolerate this treatment or
             affect compliance

          -  Pregnant and lactating women are excluded from this study. Because there is an unknown
             but potential risk for adverse events in nursing infants, breastfeeding should be
             discontinued if the mother is treated with the vaccine. These potential risks may also
             apply to other agents used in this study

          -  Patients with HIV infection, AIDS, or hepatitis B surface antigen positivity, are
             excluded from this trial. Patients on combination antiretroviral therapy are
             ineligible because of the potential for pharmacokinetic interactions. In addition,
             these patients are at increased risk of lethal infections when treated with
             marrow-suppressive therapy

          -  History of corticosteroid use in the four weeks preceding entry onto the clinical
             trial, or the requirement for ongoing corticosteroid use during the study period

          -  Patients who are expected to require therapeutic anticoagulation during the trial
             period

          -  Patients with known brain metastases