-  INCLUSION CRITERIA:

               1. Diagnosed with histologically confirmed metastatic solid tumor - cancer of the
                  lung (small cell or non small cell), prostate (adenocarcinoma), colorectum,
                  kidney (renal cell carcinoma), pancreas (adenocarcinoma),or malignant melanoma,
                  metastatic Ewing's sarcoma, or metastatic epithelial neoplasms and adenocarcinoma
                  of unknown primary, and disease confirmed to be metastatic and unresectable for
                  which standard curative or beneficial treatments are no longer effective

                  OR

                  Diagnosed with a hematological malignancy (multiple myeloma, [MM] chronic
                  myelogenous leukemia [CML] or chronic lymphocytic leukemia [CLL] or small
                  lymphocytic lymphoma [SLL]) and disease resistant or refractory to standard
                  therapy and CLL/SLL patients are required to have failed prior treatment with at
                  least one nucleoside analogue. Myeloma patients are required to have disease
                  which has progressed following treatment with bortezomib.

               2. At least 4 weeks since any prior systemic therapy (excluding corticosteroid
                  therapy) to treat the underlying malignancy (standard or investigational). NOTE:
                  subjects on FDA-approved tyrosine kinase inhibitors or other targeted therapies
                  for RCC such as mTOR inhibitors that have evidence of disease progression on
                  therapy may continue these medicines until the time of study enrollment (as
                  accelerated disease progression following discontinuation of these drugs has been
                  described).

               3. At least 2 weeks since prior palliative radiotherapy.

               4. Ages greater than or equal to 18 years and less than or equal to 70 years.

               5. Evidence of progressive disease over a 3-month interval.

               6. RBC transfusion independent (solid tumor patients only).

        EXCLUSION CRITERIA:

          1. Disease not evaluable radiographically (applies to solid tumor patients only).

          2. Disease involving greater than 25% of the liver radiographically (estimated based on
             review of liver lesions seen on CT scan).

          3. History of an allogeneic hematopoietic stem cell transplant.

          4. Brain metastases (with the exception of patients with a single brain metastasis less
             than 1cm treated with either sterotactic or gamma knife radiotherapy) due to poor
             prognosis and potential for neurological dysfunction that would confound evaluation of
             neurological and other adverse events).

          5. Peripheral neuropathy of grade greater than 1, which would require reduction of
             bortezomib dose.

          6. Acute diffuse infiltrative pulmonary disease.

          7. Acute pericardial disease.

          8. Life expectancy less than 3 months.

          9. ECOG performance status 2, 3 or 4.

         10. Uncontrolled concurrent illness including, but not limited to, symptomatic congestive
             heart failure, unstable angina pectoris, life threatening cardiac arrhythmia. Patients
             with symptoms of coronary artery disease, cardiac arrhythmias or an abnormal thallium
             stress test must be evaluated and cleared by cardiology prior to enrollment.

         11. Ongoing or active infection

         12. Contraindication for administration of pentostatin, bortezomib, and/or interleukin-2.

         13. Allergy or hypersensitivity to bortezomib, boron or mannitol by history.

         14. Concurrent use of corticosteroids.

         15. For all tumor types:

             Marrow function characterized by

             -Absolute neutrophil count less than 500/mcL (must be present off growth factors)

             Organ function characterized by

               -  Total bilirubin greater than 3 times upper limit of normal

               -  AST (SGOT)/ALT (SGPT) greater than 4 times upper limit of normal

               -  Creatinine clearance less than 50 cc/min based on a 24 hour urine collection

               -  Left ventricular ejection fraction less than 40% by echocardiogram (ECHO)

               -  Hypercalcemia greater than 2.5 mmol/L

             For all Hematologic malignancies:

             Marrow function characterized by

               -  Neutrophil count less than or equal to 500/mcl

               -  Platelets less than or equal to 20,000/mcl

         16. HIV-positive patients

         17. Hepatitis C positive patients (Hep C PCR positive)

         18. Active Hepatitis B infection (Hep B surface antigen positive)

         19. Pregnant or nursing

         20. Psychiatric illness/social situations that would limit compliance with study
             requirements and ability to comprehend the investigational nature of the study and
             provide informed consent.