Inclusion Criteria:

          -  Patients with refractory/relapse acute myeloid leukemia. Patients must not have
             received radiotherapy, chemotherapy (with the exception of hydroxyurea which must be
             discontinued 72 hours prior to therapy) or biological therapy within the preceding 2
             weeks of the planned first Neukoplast™ cell infusion and must have recovered from any
             adverse events due to prior administered agents

          -  Assessable disease as measured by laboratory and bone marrow examinations

          -  Age: Eighteen years or older

          -  Performance status: ECOG ≤ 2 (Appendix A)

          -  Serum creatinine < 2 X upper limit of normal

          -  Aspartate aminotransferase (AST) < 5 X upper limit of normal

          -  Alanine aminotransferase (ALT) < 5 X upper limit of normal

          -  Total bilirubin < 3X upper limit of normal

          -  Activated partial thromboplastin time (PTT) < 2.5 X upper limit of normal

          -  Patients must have left ventricular ejection fraction (LVEF) ≥45 %

          -  Females of child-bearing potential must have a negative pregnancy test and all
             subjects must agree to use an effective method of contraception for up to two weeks
             after the last infusion of Neukoplast™

          -  Ability to give informed consent

          -  Life expectancy of greater than 3 months

        Note: as many of eligible patients will be pancytopenic secondary to their disease or prior
        therapies hematologic abnormalities will not be used as a criteria for entry or exclusion.

        Exclusion Criteria:

          -  Patients with acute promyelocytic leukemia

          -  Symptomatic central nervous system (CNS) involvement

          -  History of congestive heart failure

          -  Evidence of severe or uncontrolled systemic diseases (e.g., unstable or uncompensated
             respiratory, hepatic, renal, or cardiac disease).

          -  Uncontrolled, life-threatening infection that is not responding to antimicrobial
             therapy

          -  ECOG performance status >2 (Appendix A)

          -  Hepatitis B or C or HIV positive serology

          -  History of psychiatric disorder which may compromise compliance with the protocol or
             which does not allow for appropriate informed consent

          -  Patient may not be receiving any other investigational agents

          -  Patient is receiving systemic anticoagulation (e.g., warfarin, intravenous heparin.
             Low dose prophylactic anticoagulation is allowed )

          -  Patient undergone autologous or allogeneic stem cell transplantation

          -  Concurrent malignancy of solid tumors. Exception: Subjects who have been disease-free
             for 5 years, or subjects with a history of completely resected non-melanoma skin
             cancer or successfully treated in situ carcinoma are eligible. Subjects with second
             malignancies that are indolent or definitively treated may be enrolled.

          -  Pregnant or lactating female.