Inclusion Criteria:

          -  Incurable advanced solid tumors that are no longer responding to conventional therapy
             or for which no effective therapy exists; at the RD of Part 1, an extension cohort up
             to 20 patients with metastatic breast cancer who are known to be BRCA mutation
             carriers will be enrolled.

          -  Age 18 years or older

          -  ECOG 0-2

          -  Life expectancy ≥ 3 months

          -  Evaluable disease

          -  Adequate bone marrow function

          -  Adequate renal function

          -  Adequate liver function

          -  At least 3 weeks from prior systemic treatments including investigational anti-cancer
             therapy, radiation therapy; and have recovered from prior toxicities

          -  Able to swallow capsules

          -  At least 3 weeks from major surgery

          -  Agree to practice effective contraception

          -  Ability to understand and willingness to sign the informed consent form

        Exclusion Criteria:

          -  Previously untreated CNS metastases or progressive CNS metastases

          -  Currently receiving radiotherapy, biological therapy, or any other investigational
             agents

          -  Uncontrolled intercurrent illness including

          -  Pregnant or lactating women

          -  Known to be HIV-positive

          -  A history of active hepatitis B and/or hepatitis C infection