Preliminary experience in the neo-adjuvant setting of Locally Advanced Breast Cancer (LABC)
      has recently demonstrated that hormone receptors negative patients have approximately 50%
      chance to achieve a pathological response after concurrent chemo-radiation. In a
      multi-institutional collaboration of 105 patients it was found that triple negative (TN)
      tumor carriers achieved pathological response in 54% of the cases and that the response
      reflected on 5-year disease free survival and overall survival. Our group has speculated that
      these effects on the risk of distant recurrence could depend on the recovery of antitumor
      immunity among the patients achieving pathological response, after tumor cell death induced
      by concurrent chemo-radiation.

      The investigators are proposing a novel study that translates these findings to the adjuvant
      setting of TN tumors. TN breast cancer is a more aggressive form of the disease often
      coinciding with basal-like tumors. BRCA mutated-cancer is more frequently TN.

      The current protocol converges the experience NYU has developed in accelerated prone breast
      radiotherapy with encouraging finding from the use of concurrent chemoradiation in LABC.

      The investigators will study the feasibility of combining weekly carboplatin with concurrent
      3-weeks prone breast radiotherapy in the adjuvant setting of 35 women with TN tumors, after
      segmental mastectomy and nodal assessment. Primary endpoint of the study is acute toxicity of
      the combined regimen, with a target of < 25% of grade II-III dermatitis.