Inclusion Criteria:

          1. Is >18 years old;

          2. Has recurrent or metastatic carcinoma of the colon or rectum with documented
             histological or cytological confirmation;

          3. Must be KRAS WT;

          4. Has measurable disease, defined as at least 1 tumor that fulfills the criteria for a
             target lesion according to RECIST 1.1;

          5. Has never received cetuximab or panitumumab, and has not received any treatment for
             colorectal cancer within 30 days prior to the first dose of study treatment under this
             protocol;

          6. Has an Eastern Cooperative Oncology Group (ECOG) score of 0-1, with a life expectancy
             of >3 months;

          7. Has received at least 2 prior chemotherapeutic regimens for colorectal cancer;

          8. Has adequate bone marrow reserve as evidenced by:

               -  Absolute neutrophil count ≥1,500/μL

               -  Platelets ≥100,000/μL;

          9. Has adequate renal function as evidenced by serum creatinine ≤2.5 × the upper limit of
             normal (ULN) for the reference lab;

         10. Has adequate hepatic function as evidenced by:

               -  Aspartate aminotransferase ≤3 × ULN for the reference lab (≤5 × ULN for subjects
                  with known hepatic metastases)

               -  Alanine aminotransferase ≤3 × ULN for the reference lab (≤5 × ULN for subjects
                  with known hepatic metastases)

               -  Bilirubin <1.5 mg/dL or direct bilirubin <1.0 mg/dL

               -  Serum Albumin >3.0 gm/dL

         11. Has read, understood and signed the informed consent form (ICF) approved by the
             Independent Review Board/Independent Ethics Committee (IRB/IEC); and

         12. If the subject is a woman of childbearing potential or a fertile man, he/she must
             agree to use an effective form of contraception during the study and for 60 days
             following the last dose of study drug (an effective form of contraception is
             abstinence, a hormonal contraceptive, or a double-barrier method).

        Exclusion Criteria:

          1. Has a known hypersensitivity to cetuximab, murine proteins, or any component of
             cetuximab;

          2. Has a known hypersensitivity to baker's yeast or has an active yeast infection;

          3. Has had previous exposure to Betafectin® or Imprime PGG;

          4. Has an active, uncontrolled infection;

          5. Has known untreated or symptomatic brain metastases;

          6. Had a second malignancy within the previous 5 years, except for basal cell carcinoma,
             cervical intra-epithelial neoplasia or treated prostate cancer with a
             prostate-specific antigen (PSA) of <2.0 ng/mL;

          7. Has known human immunodeficiency virus or acquired immune deficiency syndrome,
             hepatitis B, hepatitis C, connective tissue disease, or other clinical diagnosis,
             ongoing or intercurrent illness that in the Investigators opinion should preclude the
             subject from participation;

          8. If female, is pregnant or breast-feeding;

          9. Is receiving concurrent standard and/or investigational anti-cancer therapy or has
             received such therapy within a period of 30 days prior to the first scheduled day of
             dosing (investigational therapy is defined as treatment for which there is currently
             no regulatory-authority-approved indication); or

         10. Has previously received an organ or progenitor/stem cell transplant.