Inclusion Criteria:

          -  Relapsed or progressive medulloblastoma, ependymoma or ATRT (at least one site of
             untreated recurrent disease)

          -  Histological confirmation of medulloblastoma, ependymoma or ATRT at diagnosis or
             relapse

          -  Female or male, aged from 0 to <20 years (at time of original diagnosis)

          -  Participants must have normal organ and bone marrow function (ALT <5x institutional
             upper limit of normal, creatinine <1.5x institutional upper limit of normal for age,
             WBC >1000/mm3, platelets > 20,000/mm3. Patients with values less than WBC 2000/mm3 or
             platelets 50,000/mm3 will require initiation of treatment with etoposide and
             cyclophosphamide at a lower starting dose as defined within the protocol.

          -  Karnofsky performance status ≥50. For infants and children less than 12 years of age,
             the Lansky play scale ≥50% will be used

          -  Written informed consent of patients and / or parents

        Exclusion Criteria:

          -  Active infection

          -  VP-shunt dependency

          -  Pregnancy or breast feeding

          -  Conventional chemotherapy, antiangiogenic treatment or complete irradiation of all
             disease for current relapse (surgery may be performed before antiangiogenic treatment;
             patients with sites of disease not irradiated are still eligible for the protocol)

          -  Known hypersensitivity to any of the drugs in the protocol

          -  Active peptic ulcer

          -  Any significant cardiovascular disease not controled by standard therapy e.g. systemic
             hypertension

          -  Anticipation of the need for major elective surgery during the course of the study
             treatment

          -  Any disease or condition that contraindicates the use of the study
             medication/treatment or places the patient at an unacceptable risk of experiencing
             treatment-related complications

          -  Non-healing surgical wound

          -  A bone fracture that has not satisfactorily healed