Inclusion Criteria:

          -  Histologically confirmed NSCLC (adenocarcinoma, squamous cell carcinoma, large cell
             carcinoma, undifferentiated carcinoma or other)

          -  Stage IV cancer according to TNM classification (7th edition - UICC, December 2009;
             includes tumor with malignant pleural or pericardial effusion

          -  Tumor biopsy specimen with ≥ 50% of MUC1 expressing tumor cells determined by
             Immunohistochemistry (IHC) staining on fixed pathological material. Biopsy may come
             either from the primary tumor or from a metastasis. Cytological material is not
             accepted for this analysis

          -  Patient's naïve to first-line therapy for the advanced stage of the disease. Previous
             neoadjuvant or adjuvant therapy is allowed for patients who successfully underwent
             complete radical surgery and if last treatment was administered more than 12 months
             prior to the start of the study treatment, i.e., D1 of Cycle 1.

          -  At least one measurable lesion by CT scan or MRI based on RECIST version 1.1

          -  PS 0 or 1 on the ECOG scale

          -  Adequate hematological, hepatic, and renal function:

               -  Hemoglobin ≥ 10.0 g/dL

               -  White Blood Cells (WBC) ≥ 3.0x10E9/L including

                    -  Neutrophils ≥ 1.5x109/L

                    -  Total lymphocytes count ≥ 0.5x10E9/L

               -  Platelets count ≥ 100x10E9/L

               -  Serum alkaline phosphatase ≤ 3x ULN (upper limit of normal)in the absence of
                  liver or bone metastases or ≤5 ULN(in patients with documented bone or liver
                  metastases)

               -  Serum transaminases (alanine aminotransferase [ALT] and aspartate
                  aminotransferase [AST]) ≤ 2.5 x ULN in the absence of liver metastases or =< 5
                  ULN in case of liver metastases)

               -  Total bilirubin ≤1.5 x ULN

               -  Glomerular Filtration Rate ≥ 60 mL/min (according to Modification of the Diet in
                  Renal Disease (MDRD) formula or cockroft & Gault formula)

               -  Serum albumin ≥ 30 g/L

               -  Effective contraception during the study period and for 3 months after the last
                  study treatment administration (male and female patient)

        Exclusion Criteria:

          -  Patients having Central Nervous System (CNS) metastases. Patients who have had brain
             metastases surgically removed or irradiated with no residual disease confirmed by
             imaging are allowed

          -  Documented EGFR activating mutations (if already tested)

          -  Prior history of other malignancy except:

               -  Basal cell carcinoma of the skin

               -  Cervical intra epithelial neoplasia

               -  Other cancer curatively treated with no evidence of disease for at least 5 years

          -  Patients under chronic treatment with systemic corticoids or other immunosuppressive
             drugs (e.g., cyclosporine) for a period of at least 4 weeks and whose treatment was
             not stopped 1 week prior to the start of the study treatment (i.e., D1 of Cycle 1)

          -  Positive serology for Human Immunodeficiency Virus (HIV) or Hepatitis C Virus (HCV);
             presence in the serum of the antigens HBs

          -  Patient with any underlying medical condition that the treating physician considers
             might be aggravated by treatment or which is not controlled (e.g., elevated troponin
             or creatinine, uncontrolled diabetes)

          -  Patient with major surgery or radiotherapy within 4 weeks prior to the start of the
             study treatment (i.e., D1 of Cycle 1). Prior surgery or radiation therapy aimed at
             local palliation or attempted local disease control is permitted

          -  Patient with an organ allograft

          -  Known allergy to eggs, gentamicin or platinum-containing compounds

          -  Participation in a clinical study with an investigational product within 4 weeks prior
             to the start of the study treatment (i.e., D1 of Cycle 1)

          -  Patient unable or unwilling to comply with the protocol requirements

          -  Pregnancy or lactation

          -  Bevacizumab will be allowed for patients with non-squamous carcinoma. Prescribing
             information must be followed and precautions have to be taken into consideration
             (e.g., patients having presented a serious hemorrhage or recent hemoptysis should not
             receive bevacizumab).