Inclusion Criteria:

          1. Male or female patients 18 years or over.

          2. Patients must have all of the following:

               -  be enrolled within 3 months of initial diagnosis of CML-CP (date of initial
                  diagnosis is the date of first cytogenetic analysis)

               -  cytogenetic confirmation of the Philadelphia chromosome or variants of (9;22)
                  translocations

               -  patients may have secondary chromosomal abnormalities in addition to the
                  Philadelphia chromosome.

               -  < 15% blasts in peripheral blood and bone marrow;

               -  < 30% blasts plus promyelocytes in peripheral blood and bone marrow;

               -  < 20% basophils in peripheral blood,

               -  100 x 109/L platelets or greater

               -  no evidence of extramedullary leukaemic involvement, with the exception of the
                  hepatosplenomegaly.

          3. Written voluntary informed consent.

        Exclusion Criteria:

          1. Patients with Ph-negative, BCR-ABL-positive, disease are NOT eligible for the study.

          2. Any prior treatment for CML with: any tyrosine kinase inhibitor (eg imatinib,
             dasatinib); busulphan; interferon-alpha; homoharringtonine; cytosine arabinoside; any
             other investigational agents (hydroxycarbamide and anagrelide are the only drugs
             permitted). NB patients will be ineligible for the study if they have received ANY
             prior therapy with interferon-alpha or imatinib. NO exceptions.

          3. Patients who received prior chemotherapy, including regimens used in peripheral blood
             progenitor cells (PBPCs) mobilisation for haematopoietic progenitor-cell
             transplantation. (It is allowable to collect unmobilised PBPCs at diagnosis.)

          4. Patient who have had any form of prior haemopoietic stem cell transplant, either
             autograft or allograft.

          5. Patients with an ECOG Performance Status Score of 2 or less.

          6. Patients with serum bilirubin, SGOT/AST, SGPT/ALT, or creatinine concentrations > 2.0
             x the institutional upper limit of the normal range (IULN).

          7. Patients with International normalized ratio (INR) or partial thromboplastin time
             (PTT) > 1.5 x IULN, with the exception of patients on treatment with oral
             anticoagulants.

          8. Patients with uncontrolled medical disease such as diabetes mellitus, thyroid
             dysfunction, neuropsychiatric disorders, infection, angina, or Grade 3/4 cardiac
             problems as defined by the New York Heart Association Criteria.

          9. Patients with known positivity for human immunodeficiency virus (HIV); baseline
             testing for HIV is not required.

         10. Patients who have undergone major surgery within 4 weeks of Study Day 1, or who have
             not recovered from prior major surgery.

         11. Patients who are:

               -  pregnant,

               -  breast feeding,

               -  of childbearing potential without a negative pregnancy test prior to Study Day 1,
                  and

               -  male or female of childbearing potential unwilling to use barrier contraceptive
                  precautions throughout the trial (postmenopausal women must be amenorrheic for at
                  least 12 months to be considered of non-childbearing potential).

         12. Patients with a history of another malignancy either currently or within the past five
             years, with the exception of basal cell skin carcinoma or cervical carcinoma in situ.

         13. Patients with a history of non-compliance to medical regimens or who are considered
             potentially unreliable.