Inclusion Criteria:

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

          -  Must have recovered from all side effects of their most recent systemic or local
             treatment

          -  Adequate hematological, renal and liver function

        For solid tumors only:

          -  Histologically confirmed cancers (excluding melanoma and papillary thyroid cancer)
             with a BRAF V600 mutation and that are resistant to standard therapy or for which
             standard or curative therapy does not exist

          -  Measurable disease according to Response Evaluation Criteria In Solid Tumors (RECIST)

        For multiple myeloma only:

          -  Confirmed diagnosis of multiple myeloma with a BRAF V600 mutation

          -  Must have received at least one prior systemic therapy for the treatment of multiple
             myeloma

          -  Treated with local radiotherapy

          -  Must have relapsed and/or refractory multiple myeloma with measurable disease

        Exclusion Criteria:

          -  Melanoma, papillary thyroid cancer or hematological malignancies (with the exception
             of multiple myeloma)

          -  Uncontrolled concurrent malignancy

          -  Multiple myeloma: solitary bone or solitary extramedullary plasmacytoma as the only
             evidence of plasma cell dyscrasia

          -  Active or untreated central nervous system (CNS) metastases

          -  History of or known carcinomatous meningitis

          -  Concurrent administration of any anti-cancer therapies other than those administered
             in this study

          -  Other severe, acute, or chronic medical or psychiatric condition or laboratory
             abnormality that would, in the investigator's opinion, contraindicate participation in
             this study