Inclusion Criteria:

- Age 18 years

- Patients must have histologically confirmed medulloblastoma (including posterior
fossa primitive neuroectodermal tumor) for which no known curative therapy exists

- Patients must have recurrent or refractory disease

- Patients must have evidence of measurable disease or lesion in pre-inclusion MRI.
Patients with measurable spinal disease are eligible. NB: Patients with complete
resection for recurrence are not eligible.

- Activation of the SHH pathway validated by IHC.

- ECOG performance status 0, 1 or 2 (Appendix 4).

- Life expectancy 12 weeks

- Patients must have normal organ and marrow function as defined below:

Neutrophils 1. 5 G/L Platelets 100 G /L Hemoglobin 10g/dL Creatinine clearance 50
mL/min (calculated by Cockcroft-Gault formula or MDRD formula for patients older than 65
years ) or serum creatinine within normal limits or less than 1.5 x upper limit of normal
(ULN) Total bilirubin 1.5 ULN ALAT and ASAT 2.5 ULN Serum albumin 25 g/L.

- Patients recovered from prior treatment-related toxicity (persistent treatment
related toxicity <Grade 2 are allowed (NCI-CTCAE v4.0).

- Prior therapy:

No prior hedgehog antagonist vismodegib or other antagonists of the hedgehog pathway, and
no prior temozolomide treatment for patients to be randomized in Arm A or B. Patients
previously treated with temozolomide are eligible for enrollment in study arm C on a case
by case basis and following sponsor agreement More than 4 weeks since prior
myelosuppressive chemotherapy (6 weeks for nitrosoureas, 6 months after high dose therapy)
or immunotherapy At least 3 months since prior craniospinal irradiation ( 23 Gy) At least
8 weeks since prior local irradiation to primary tumor At least 2 weeks since prior focal
irradiation for symptomatic metastatic sites.

At least 1 week since prior colony-stimulating factors (e.g., G-CSF, GM-CSF, or
erythropoietin)

- Women of childbearing potential* are required to have a negative serum pregnancy test
within 72 hours prior to study treatment initiation (i.e. Cycle 1 Day 1).

*: Female patients who meet at least one of the following criteria are defined as
women of non-childbearing potential:

50 years old and naturally amenorrheic for 1 year Permanent premature ovarian
failure confirmed by a specialist gynaecologist Previous bilateral
salpingo-oophorectomy XY genotype, Turner's syndrome, or uterine agenesis Female
patient who do not meet at least of the above criteria are defined as women of
childbearing potential.

- An embryo-fetal development study in rats has confirmed the teratogenic potential of
vismodegib. Therefore, women of child-bearing potential and men must use two forms of
effective contraception (including one barrier method- refer to Appendix 5 for
acceptable method of contraception) at least 4 weeks prior to study entry, during the
study period and for at least 7 months post-treatment. Prior to dispensing
vismodegib, the investigator must confirm and document the patient's use of two
contraceptive methods, dates of negative pregnancy test, and confirm the patient's
understanding of the teratogenic potential of vismodegib.

- Ability to understand and willingness to comply to follow-up visits.

- Covered by a medical insurance (in countries where applicable)

Exclusion Criteria:

- Tumor tissue sample not available for biological studies (from the initial diagnosis
and/or relapse)

- Pregnant or breastfeeding women are not eligible.

- History of allergic reactions attributed to compounds of similar chemical composition
to vismodegib.

- Any contraindications to temozolomide treatment as per Temodal SPC (see Appendix 6).

- Patients with malabsorption syndrome or other condition that would interfere with
intestinal absorption. Patients must be able to swallow capsules.

- Uncontrolled hypocalcemia, hypomagnesemia, hyponatremia, or hypokalemia, defined as
less than the lower limit of normal despite adequate electrolyte supplementation.

- History of congestive heart failure.

- History of ventricular arrhythmia requiring medication.

- Congenital long QT syndrome.

- Clinically significant unrelated systemic illness (e.g., serious infection or
significant cardiac, pulmonary, hepatic, or other organ dysfunction) that would
compromise the patient's ability to tolerate study treatment or would likely
interfere with study procedures or results.

- Patients using prohibited concomitant and/or concurrent medications (see section
"Prohibited concomitant/concurrent treatments.)

Minimum Eligible Age: 18 Years

Maximum Eligible Age: N/A

Eligible Gender: Both