If screening tests show that you are eligible to participate in the research study you will
      begin study treatment. You may undergo an optional research biopsy so the study team can
      obtain tissue samples. This will be used for biomarker research and will help your doctors to
      better understand your disease, how the drug is working in your body, and may help to
      identify which people may benefit most from platinum or from adriamycin/cytoxan in the
      future.

      Because no one knows which of the study options is best, you will be "randomized" to receive
      either cisplatin or doxorubicin and cyclophosphamide ("AC") chemotherapy prior to removal of
      your breast cancer. Chemotherapy administered before the removal of the cancer is known as
      neoadjuvant chemotherapy. Randomization means that you are put into a group by chance. It is
      like flipping a coin. Neither you nor the research doctor will choose what group you will be
      in. You will have an equal chance of being placed in either group.

      If you are randomized to receive cisplatin you will receive cisplatin once every three weeks
      for a total of four doses. You will be given cisplatin by vein (IV) on the first day of each
      treatment cycle. The cisplatin infusion can take between 1 to 2 hours. Before and after
      receiving cisplatin, you will receive fluid hydration by vein, and you will also be given
      medicine to help prevent side effects such as nausea. The total time of the infusion of
      cisplatin and the additional fluid and medications will take about 6 hours. After you receive
      cisplatin, you will be asked to drink about 12 eight ounce glasses of fluid per day,
      especially 2 or 3 days after therapy. The study treatment will stop if you have serious side
      effects or if the tumor grows despite receiving cisplatin chemotherapy.

      If you are randomized to "AC" chemotherapy you will receive both doxorubicin and
      cyclophosphamide once every 2 or 3 weeks for a total of four doses by vein on the first day
      of each treatment cycle. The interval between chemotherapy will be decided by your research
      doctor. If you receive the chemotherapy every two weeks, you will also receive a subcutaneous
      injection the day after chemotherapy. This injection contains a medicine that contains a
      growth factor that will boost your immune system in order to allow your body to be ready for
      chemotherapy in two weeks. The study treatment will be stopped if you have serious side
      effects or if the tumor grows despite the doxorubicin and cyclophosphamide chemotherapy.

      At the beginning of each treatment cycle you will have a physical exam (including weight and
      vital signs) and you will be asked general questions about your health and any medications
      you may be taking, as well as specific questions about any side effects you may be
      experiencing while receiving study treatment. Prior to each cycle of chemotherapy, you will
      have standard blood tests to check your blood counts. If you are receiving cisplatin your
      kidney function and body salts will also be checked prior to each chemotherapy cycle. In
      addition, 7-10 days after chemotherapy your blood will be drawn to look at your blood cell
      count to determine your risk of infection; if you have received cisplatin, your kidney
      function and blood electrolytes will also be evaluated. The blood draw performed 7-10 days
      after chemotherapy can be done in the hospital where you received your chemotherapy or closer
      to home. About 1 tablespoon of blood will be drawn for these tests.

      Surgery to remove your tumor will occur within six weeks after the last dose of chemotherapy.
      Your surgery will be performed by your surgeon, as part of the standard care for your
      disease.

      Your treating physician or nurse practitioner will examine you to assess your tumor each time
      you receive chemotherapy. A measurement of your tumor will be performed on the first day of
      each treatment cycle as part of your physical exam. After the slides of your initial breast
      cancer biopsy have been reviewed at your hospital, these slides and your tumor block will be
      sent to the study pathologist at DF/HCC. Likewise, after chemotherapy, your breast cancer
      will be removed by lumpectomy or mastectomy. After these slides are reviewed at your
      hospital, they will also be sent with the tumor block to the study pathologist so that the
      response of your tumor to the study treatment can be assessed. After these slides are
      reviewed, they will be returned to the hospital at which the biopsy and surgery were
      performed.

      Decisions about whether you will receive more chemotherapy after your surgery is up to your
      treating physicians. If you receive chemotherapy, the choice of chemotherapy is also up to
      your doctors. Decisions about post-operative chemotherapy are not part of this study.