Inclusion Criteria:

          -  Subjects who provide written informed consent to participate in the study

          -  Men and women patients 18 years of age and up

          -  Have an unresectable, locally advanced pancreatic cancer (AJCC stage III). (Excluded:
             resectable and borderline resectable patients are ineligible per NCCN criteria)

          -  Allocated to receive Gemcitabine + nab-Paclitaxel as first line treatment.

          -  Have a target tumor that is accessible for intratumoral administration by PTA
             (Percutaneous transluminal approach) or EUS (Endoscopic Ultrasound) guidance as
             determined by the radiologist/gastroenterologist performing the PTA/EUS injection.

          -  Have an ECOG performance status of ≤ 1

          -  If female and of childbearing potential, have a negative serum or urine pregnancy
             test during screening. Agree to use a barrier method of contraception if sexually
             active (both men and women) from the time of administration of the first treatment
             and for at least 8 weeks after treatment.

          -  Have serum creatinine <1.6 mg/dL, INR < 1.5 U, absolute neutrophil count (ANC) > 1 x
             109/L , platelets ≥ 100 x 109/L , hemoglobin ≥ 10 mg/dL, ALT and AST ≤ 3 x ULN,
             bilirubin ≤ 1.5 x ULN

          -  Have measurable disease. Patients must have clinically and/or radiographically
             documented measurable primary disease according to RECIST 1.1. At least one site of
             disease must be unidimensionally measurable. All radiology scans must be performed
             within 28 days prior to registration

        Exclusion Criteria:

          -  Evidence of metastatic disease

          -  Other malignancy that would interfere with the current intervention

          -  Any evidence of ascites (beyond trace)

          -  Bulky celiac adenopathy (≥2.5 cm) or nonadenocarcinoma histology.

          -  Any prior therapy for the treatment of pancreatic malignancy (including chemotherapy,
             immunotherapy, vaccines, monoclonal antibodies, major surgery, or irradiation,
             whether conventional or investigational).

          -  Prior therapy with any hypoxic cytotoxin (hypoxia-targeting drugs).

          -  Previously treated malignancies, except for adequately treated non-melanoma skin
             cancer, in situ cancer, or other cancers from which the subject has been disease-free
             for at least 2 years

          -  Severe chronic obstructive or other pulmonary disease with hypoxemia (requires
             supplementary oxygen, symptoms due to hypoxemia or oxygen saturation <90% by pulse
             oximetry after a 2 minute walk) or in the opinion of the investigator any
             physiological state likely to cause systemic or regional hypoxemia

          -  History of clinically significant coagulopathy

          -  Major surgery, other than diagnostic surgery, within 4 weeks prior to Day 1, without
             complete recovery

          -  New York Heart Association (NYHA) Class III or IV, cardiac disease, myocardial
             infarction within 4months prior to Day 1, unstable arrhythmia or symptomatic
             peripheral arterial vascular disease

          -  Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic
             therapy

          -  Subjects who participated in an investigational drug or device study within 28 days
             prior to study entry

          -  Known active infection with HIV, hepatitis B virus, or hepatitis C virus

          -  Females who are pregnant or breast-feeding

          -  Concomitant disease or condition that could interfere with the conduct of the study,
             or that would, in the opinion of the investigator, pose an unacceptable risk to the
             subject in this study

          -  Unwillingness or inability to comply with the study protocol for any reason

          -  Participation in another clinical trial with drugs received within 3 months prior to
             dosing (calculated from the previous study's last dosing date).