Clinical Trials /

Belinostat and Yttrium Y 90 Ibritumomab Tiuxetan in Patients W/Relapsed Aggressive B-Cell NHL

NCT01686165

Description:

This study looks at what effects (good and bad) a drug called PXD-101 (belinostat) in combination with the radioactive drug Zevalin (yttrium Y 90 ibritumomab tiuxetan) has on patients with relapsed aggressive (high-risk) non-Hodgkin lymphoma. Studies in the laboratory suggest that drugs such as PXD101 can act upon specific cancer cell processes to cause either death of the cancer cells or prevention of their growth. In human studies with a small number of patients with this lymphoma, PXD-101 has shown the ability to shrink and slow tumor growth. When Zevalin is delivered directly to the tumor, the lymphoma cells are destroyed and this may result in the disappearance of the tumor (remission)

Related Conditions:
  • Diffuse Large B-Cell Lymphoma
  • Mature B-Cell Lymphoma/Leukemia
Recruiting Status:

Completed

Phase:

Phase 2

Trial Eligibility

Document

<span class="go-doc-concept go-doc-intervention">Belinostat</span> and Yttrium Y 90 Ibritumomab Tiuxetan in Patients W/Relapsed Aggressive B-Cell NHL

Title

  • Brief Title: Belinostat and Yttrium Y 90 Ibritumomab Tiuxetan in Patients W/Relapsed Aggressive B-Cell NHL
  • Official Title: A Phase II Exploratory Study of PXD-101(Belinostat) Followed by Zevalin in Patients With Relapsed Aggressive High-Risk Lymphoma
  • Clinical Trial IDs

    NCT ID: NCT01686165

    ORG ID: 12-0288-04

    NCI ID: NCI-2012-01131

    Trial Conditions

    Anaplastic Large Cell Lymphoma

    Recurrent Adult Diffuse Large Cell Lymphoma

    Recurrent Mantle Cell Lymphoma

    Trial Interventions

    Drug Synonyms Arms
    belinostat PXD101 Treatment (belinostat, yttrium Y 90 ibritumomab tiuxetan)

    Trial Purpose

    This study looks at what effects (good and bad) a drug called PXD-101 (belinostat) in
    combination with the radioactive drug Zevalin (yttrium Y 90 ibritumomab tiuxetan) has on
    patients with relapsed aggressive (high-risk) non-Hodgkin lymphoma. Studies in the
    laboratory suggest that drugs such as PXD101 can act upon specific cancer cell processes to
    cause either death of the cancer cells or prevention of their growth. In human studies with
    a small number of patients with this lymphoma, PXD-101 has shown the ability to shrink and
    slow tumor growth. When Zevalin is delivered directly to the tumor, the lymphoma cells are
    destroyed and this may result in the disappearance of the tumor (remission)

    Detailed Description

    PRIMARY OBJECTIVES:

    I. To document the complete response rate and overall response for patients with relapsed
    aggressive high-risk non-Hodgkin's lymphoma treated with two cycles PXD-101 followed by one
    cycle of Zevalin.

    SECONDARY OBJECTIVES:

    I. To estimate 2-year progression-free survival in patients with relapsed aggressive
    high-risk non-Hodgkin's lymphoma treated with two cycles PXD-101 followed by one cycle of
    Zevalin.

    II. To evaluate the toxicity of two cycles PXD-101 and one cycle of Zevalin in patients with
    relapsed aggressive high-risk non-Hodgkin's lymphoma.

    OUTLINE:

    Patients receive belinostat intravenously (IV) over 30-60 minutes on days 1-5. Treatment
    with belinostat repeats every 21 days for 2 courses. Patients then receive rituximab IV on
    days 1 and either 7, 8, or 9, and yttrium Y 90 ibritumomab tiuxetan IV over 10 minutes on
    day 50. Treatment continues in the absence of disease progression or unacceptable toxicity.

    After completion of study treatment, patients are followed up every 3 months for 2 years and
    then every 6 months for 3 years.

    Trial Arms

    Name Type Description Interventions
    Treatment (belinostat, yttrium Y 90 ibritumomab tiuxetan) Experimental Patients receive belinostat IV over 30-60 minutes on days 1-5. Treatment with belinostat repeats every 21 days for 2 courses. Patients then receive rituximab IV on days 1 and either 7, 8, or 9, and yttrium Y 90 ibritumomab tiuxetan IV over 10 minutes on day 50. Treatment continues in the absence of disease progression or unacceptable toxicity. belinostat

    Eligibility Criteria

    Inclusion Criteria:

    - Biopsy confirmed, CD20 positive diffuse large B-cell lymphoma, primary mediastinal
    b-cell lymphoma, mantel cell lymphoma, transformed indolent lymphoma, high
    grade-B-cell lymphoma; AND bone marrow must show =< 20% CD20+ B-cells with >= 15%
    cellularity within 42 days of study registration

    - Any stage disease

    - Patients must have been previously treated:

    - >= 3rd line if bone marrow transplant (BMT) candidate OR

    - >= 2nd line if not BMT candidate OR

    - >= 2nd relapse for BMT candidate OR

    - >= 1st relapse for non- BMT candidate

    - Must have a diagnostic quality CT scan of the chest, abdomen and pelvis OR baseline
    PET-CT scan performed within 28 days prior to registration

    - Must have bidimensionally measurable disease with lesions at least 1.5 cm in one
    dimension ALL measurable disease must be assessed within 28 days of registration

    - To determine prior drug regimens: radiation therapy counts as 1 treatment, BMT
    including induction counts as one treatment, radioimmunotherapy is not considered a
    chemotherapy regimen, rituximab alone is not considered a treatment; all prior
    therapy must have been completed at least 30 days prior to registration; patients
    should not have taken valproic acid, or any other histone deacetylase inhibitor (eg.,
    vorinostat, romidepsin), for at least 30 days prior to registration; patients must
    have recovered from any toxicities related to therapies prior to registration

    - No clinical evidence of CNS involvement by lymphoma, any lab (eg., LDH or
    radiographic tests performed to access CNS involvement must be negative and must be
    performed within 42 days prior to registration

    - Unilateral or bilateral bone marrow biopsy performed within 42 days prior to
    registration

    - Life expectancy of greater than 3 months

    - Karnofsky performance status >= 60%

    - Leukocytes >= 3,000/mcL

    - Absolute neutrophil count >= 1,500/mcL

    - Platelets >= 100,000/mcL

    - AST (SGOT)/ALT(SGPT) =< 2.5 X institutional upper limit of normal

    - Total bilirubin =< 1.5 X institutional upper limit of normal (unless associated with
    Gilbert's syndrome)

    - Serum creatinine < 2 x institutional upper limit of normal OR

    - Measured creatinine clearance >= 60 mL/min

    - LDH < 1.50 X institutional upper limit of normal

    - EKG with no significant abnormalities within 28 days prior to registration

    - Women of child-bearing potential and men must agree to use adequate contraception

    Exclusion Criteria:

    - Patients who have had chemotherapy or radiotherapy within 30 days (6 weeks for
    nitrosoureas or mitomycin C) prior to study screening or those who have not recovered
    from adverse events due to agents administered more than 4 weeks earlier

    - Prior radioimmunotherapy

    - Pregnant or nursing

    - Clinical evidence of CNS involvement by lymphoma

    - History of allergic reactions attributed to compounds of similar chemical or biologic
    composition to PXD-101 or Zevalin or other agents used in the study

    - Concomitant medication that may cause Torsade de Pointes, i.e. prolongation of the QT
    interval > 500 msec

    - Significant cardiovascular disease including unstable angina pectoris, uncontrolled
    hypertension, congestive heart failure related to primary cardiac disease, any
    condition requiring anti-arrhythmic therapy, ischemic or valvular heart disease, or a
    myocardial infarction within the past 6 months

    - Current long QT syndrome or baseline prolongation of QT/QTcF interval, i.e.
    demonstration of a QTcF interval > 450 msec

    - Clinical evidence of severe peripheral vascular disease, diabetic ulcers or venous
    stasis ulcers, or history of deep venous or arterial thrombosis within 3 months prior
    to screening

    - Known to be human immunodeficiency virus (HIV) positive or with known acquired
    immunodeficiency syndrome (AIDS) syndrome

    - Patients may not be receiving any other investigational agents

    Minimum Eligible Age: 18 Years

    Maximum Eligible Age: N/A

    Eligible Gender: Both

    Primary Outcome Measures

    Complete response rate

    Overall response

    Secondary Outcome Measures

    Progression-free survival

    Occurrence of adverse events and serious adverse events

    Trial Keywords