Inclusion Criteria:

- HER2-positive disease determined locally

- Histologically or cytologically confirmed invasive breast cancer

- Prior treatment for breast cancer in the adjuvant, unresectable, locally advanced or
metastatic setting must include both chemotherapy, alone or in combination with
another agent, and an anti-HER2 agent, alone or in combination with another agent

- Documented progression of incurable, unresectable, locally advanced, or metastatic
breast cancer (mBC), defined by the investigator: progression must occur during or
after most recent treatment for locally advanced/mBC or within 6 months of completing
adjuvant therapy

- Measurable and/or non-measurable disease

- Left ventricular ejection fraction (LVEF) >/=50% by either echocardiogram (ECHO) or
multiple-gated acquisition scan (MUGA)

- Eastern Cooperative Oncology Group (ECOG) performance status of 0,1 or 2

- Adequate organ function

- Use of highly effective contraception as defined by the protocol

- Cohort 2: only Asian patients will be enrolled

Exclusion Criteria:

- History of treatment with Kadcyla

- Prior enrollment into a clinical study containing Kadcyla regardless of having
received Kadcyla or not

- Peripheral neuropathy of Grade >/= 3 per National Cancer Institute (NCI) common
terminology criteria for adverse events (CTCAE) v. 4.0

- History of other malignancy within the previous 5 years, except for appropriately
treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, Stage 1 uterine
cancer, synchronous or previously diagnosed HER2-positive breast cancer

- History of receiving any anti-cancer drug/biologic or investigational treatment
within 21 days prior to first study treatment except hormone therapy, which can be
given up to 7 days prior to first study treatment; recovery of treatment-related
toxicity consistent with other eligibility criteria

- History of exposure to cumulative doses of anthracyclines

- History of radiation therapy within 14 days of first study treatment. The patient
must have recovered from any resulting acute toxicity (to Grade </=1) prior to first
study treatment.

- Central nervous system (CNS)-only disease

- Brain metastases which are symptomatic

- History of a decrease in LVEF to < 40% or symptomatic congestive heart failure (CHF)
with previous trastuzumab treatment

- History of symptomatic CHF (New York Heart Association [NYHA] Classes II-IV) or
serious cardiac arrhythmia requiring treatment

- History of myocardial infarction or unstable angina within 6 months of first study
treatment

- Current dyspnea at rest due to complications of advanced malignancy or requirement
for continuous oxygen therapy

- Current severe, uncontrolled systemic disease (e.g., clinically significant
cardiovascular, pulmonary, or metabolic disease)

- Currently known active infection with HIV, hepatitis B virus, or hepatitis C virus

Minimum Eligible Age: 18 Years

Maximum Eligible Age: N/A

Eligible Gender: Both