Description:
The goal of this study is to characterize the safety, maximum tolerated dose (MTD) and
preliminary efficacy profile of IPI-145 given in combination with rituximab, or bendamustine
plus rituximab, to subjects with select relapsed/refractory hematologic malignancies.
Title
- Brief Title: Study of IPI-145 in Combination With Rituximab or Bendamustine/Rituximab in Hematologic Malignancies
- Official Title: An Open-label, Phase Ib Study of IPI-145 in Combination With Rituximab or Bendamustine/Rituximab in Select Subjects With Lymphoma or Chronic Lymphocytic Leukemia
Clinical Trial IDs
- ORG STUDY ID:
SCRI HEMREF 34
- NCT ID:
NCT01871675
Conditions
- Lymphoma
- Chronic Lymphocytic Leukemia
- Non-Hodgkin Lymphoma
- T-cell Lymphoma
Interventions
Drug | Synonyms | Arms |
---|
IPI-145 | Duvelisib | Arm 1: IPI-145 plus Rituximab |
Rituximab | Rituxan | Arm 1: IPI-145 plus Rituximab |
Bendamustine | Treanda | Arm 2: IPI-145 plus Rituximab/Bendamustine |
Purpose
The goal of this study is to characterize the safety, maximum tolerated dose (MTD) and
preliminary efficacy profile of IPI-145 given in combination with rituximab, or bendamustine
plus rituximab, to subjects with select relapsed/refractory hematologic malignancies.
Detailed Description
This trial consists of two parallel arms. For each treatment arm, a 3+3 dose escalation
design will be applied in 3-6 subject cohorts until the maximum tolerated dose of IPI-145
when given with rituximab (Arm 1) or in combination with rituximab and bendamustine (Arm 2)
is determined. Treatment arm selection will be chosen by the investigator and will depend on
the agents previously administered to the subject. Once the MTD has been determined, the arms
will move on to a dose expansion phase. During the dose expansion phase, each treatment arm
will enroll to population specific cohorts to assess efficacy. All subjects must have had at
least one prior anticancer treatment. The dose expansion cohorts are:
Arm 1: Cohort A - CLL: Cohort B - CD20+ NHL
Arm 2: Cohort A - CLL: Cohort B - CD20+ NHL
Trial Arms
Name | Type | Description | Interventions |
---|
Arm 1: IPI-145 plus Rituximab | Experimental | IPI-145 will be administered orally, twice daily, in 28-day (4-week) cycles, on a continuous basis at the maximum tolerated dose of 25 mg twice-daily (BID), as determined in the dose escalation phase. Twelve (12) cycles of IPI-145 will be administered. Patients who benefit from treatment may continue on study for additional cycles until toxicity or progressive disease.
Rituximab 375 mg/m2 will be administered intravenously (IV) beginning on Day 1 once weekly during a 28 day cycle; 2 cycles of rituximab will be administered. | |
Arm 2: IPI-145 plus Rituximab/Bendamustine | Experimental | IPI-145 will be administered orally, twice daily, in 28 day cycles, on a continuous basis, until disease progression, unacceptable toxicity or patient refusal. The maximum tolerated dose of IPI-145 will be 25 mg twice-daily (BID) as determined in the dose escalation phase. Twelve (12) cycles of IPI-145 will be administered. Patients who benefit from treatment may continue on study for additional cycles until toxicity or progressive disease.
Rituximab 375 mg/m2 will be administered intravenously (IV) beginning on Day 1 once weekly of each 28 day cycle. A maximum of 6 cycles of rituximab will be given. Bendamustine 90 mg/m2 IV will be administered on Days 1 and 2, of each 28 day cycle. Rituximab should be administered prior to bendamustine. | - IPI-145
- Rituximab
- Bendamustine
|
Eligibility Criteria
Inclusion Criteria:
1. Dose Escalation Phase
Arm 1 and Arm 2: Limited to subjects diagnosed with low grade CD-20 positive B-Cell
NHL with at least one prior anticancer treatment.
2. Dose Expansion Phase
Arm 1 Cohort A: Limited to subjects with CD-20 positive CLL with at least one prior
anticancer treatment.
Arm 1 Cohort B: Limited to subjects with diagnosis of CD-20 positive NHL with at least
one prior anticancer treatment.
Arm 2 Cohort A: Limited to subjects with CD-20 positive CLL with at least one prior
anticancer treatment.
Arm 2 Cohort B: Limited to subjects with diagnosis of CD-20 positive NHL with at least
one prior anticancer treatment.
3. Disease status requirement:
- CLL subjects: symptomatic disease that mandate treatment;
- Indolent NHL subjects: symptomatic disease requiring treatment according to the
clinical judgment of the investigator;
- Other lymphoma subjects: disease requiring treatment according to the judgment of
the investigator.
4. Eastern Cooperative Oncology Group (ECOG) Performance Status score of ≤2.
5. Subject must have measurable disease using the disease-specific response criteria for
NHL or CLL
6. Age ≥ 18 years.
7. Subject has recovered from all clinically significant toxicities related to prior
antineoplastic therapies with the exception of alopecia and bone marrow and organ
functions.
8. Adequate organ system function ≤2 weeks prior to Day 1, defined as follows:
- Absolute neutrophil count (ANC) ≥1.0 x 109/L unless related to underlying CLL or
indolent NHL bone marrow involvement, and then ANC ≥500 x 109/L permitted.
- Platelets ≥100 x 109/L unless related to underlying CLL or indolent NHL bone
marrow involvement, and then platelets ≥75 x 109/L permitted.
- Subjects receiving IPI-145 plus rituximab with bone marrow involvement may enroll
with platelets ≥40 x 109/L.
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤1.5 x ULN
and total bilirubin ≤1.5 times the upper limit of normal (ULN) (except for
subjects with Gilbert's disease)
- Serum creatinine ≤1.5 x ULN
9. Life expectancy of ≥12 weeks.
10. Women of child-bearing potential (WCBP) must have a negative serum or urine pregnancy
test.
11. Ability to understand the nature of this study and give written informed consent.
Exclusion Criteria:
1. Prior allogeneic hematopoietic stem cell transplant (HSCT).
2. Prior autologous transplant or radioimmunotherapy ≤6 months prior to the first dose of
trial treatment.
3. Subject has a high grade lymphoma such as Burkitt's, lymphoblastic or small
non-cleaved cell lymphomas. Subjects with intermediate grade lymphoma (such as diffuse
large B-cell lymphoma) are eligible.
4. Subjects with diffuse B-cell lymphoma must either not be eligible for autologous bone
marrow transplant (BMT) or relapsed after autologous BMT.
5. More than three previous cytotoxic chemotherapy regimens for subjects treated on the
arm containing bendamustine.
6. Subjects who have had a severe allergic or anaphylactic reaction to any humanized or
murine monoclonal antibodies.
7. Chemotherapy, cancer immunosuppressive therapy, growth factors (except
erythropoietin), radiation therapy (other than whole brain irradiation [WBI]) surgery
or ablative therapy or investigational drugs/devices ≤28 days before first dose of
trial treatment.
8. Subjects receiving high doses of corticosteroids must have been tapered to a stable
dose at least 7 days before the first dose of trial treatment.
9. Tyrosine kinase inhibitor within 7 days prior to the first dose of trial treatment.
10. Subjects with overt leptomeningeal leukemia or central nervous system (CNS) lymphoma.
Subjects must be free of CNS disease for a minimum of 2 months. Subjects with symptoms
of CNS disease must have a negative diagnostic lumbar puncture prior to study
enrollment.
11. Subjects with a history of stroke, unstable angina, myocardial infarction, or
ventricular arrhythmia requiring medication or mechanical control within the last 6
months.
12. Baseline QTcF >480 ms. Note: This criterion does not apply to subjects with a left
bundle branch block.
13. Subjects who have had a venous thromboembolic event requiring anticoagulation and who
meet any of the following criteria:
- Have been on a stable dose of anticoagulation for <1 month.
- Have had a Grade 2, 3 or 4 hemorrhages in the last 30 days.
- Are experiencing continued symptoms for their venous thromboembolic event.
14. Subjects with a history of liver disease as a result of alcohol abuse, chronic
hepatitis, or other chronic liver disease (other than metastatic disease to the
liver).
15. Subjects with positive HBsAg, HBcAb or HCV are excluded.
16. Subjects with a history of tuberculosis within the preceding two years.
17. Prior surgery affecting drug absorption or any gastrointestinal dysfunction that could
alter drug absorption.
18. Subjects with a known hypersensitivity to bendamustine or rituximab.
19. Presence of active infection within 72 hours of treatment. Subjects with ongoing use
of prophylactic antibiotics are eligible as long as there is no evidence of active
infection and the antibiotic is not included on the list of prohibited medications.
20. Known diagnosis of human immunodeficiency virus (HIV).
21. Concurrent administration of medications or foods that are strong or moderate
inhibitors or inducers of CYP3A.
22. Women who are pregnant or lactating.
23. Psychological, familial, sociological, or geographical conditions that do not permit
compliance with the protocol.
24. Concurrent condition that in the investigator's opinion would jeopardize compliance
with the protocol or would impart excessive risk associated with study participation
that would make it inappropriate for the subject to be enrolled.
25. Inability or unwillingness to comply with study and/or follow-up procedures outlined
in the protocol.
Maximum Eligible Age: | N/A |
Minimum Eligible Age: | 18 Years |
Eligible Gender: | All |
Healthy Volunteers: | No |
Primary Outcome Measures
Measure: | The number of adverse events, serious adverse events, and dose limiting toxicities as a measure of safety and tolerability |
Time Frame: | up to 12 months |
Safety Issue: | |
Description: | The maximum tolerated dose of IPI-145 defined as the optimal dose at which ≤1 of 6 patients experiences a DLT assessed by NCI CTCAE v4.0. |
Secondary Outcome Measures
Measure: | Antitumor activity |
Time Frame: | Up to 5 years |
Safety Issue: | |
Description: | Preliminary information on antitumor activity of IPI-145 when combined with rituximab, or bendamustine/rituximab as measured by objective response rate, progression free survival and overall survival data |
Details
Phase: | Phase 1 |
Primary Purpose: | Interventional |
Overall Status: | Completed |
Lead Sponsor: | SCRI Development Innovations, LLC |
Trial Keywords
- Lymphoma
- Chronic Lymphocytic Leukemia
- Non-Hodgkin Lymphoma
- T-cell Lymphoma
- Rituxan
- Bendamustine
- Hematologic Malignancy
- Relapsed
- Refractory
Last Updated
July 11, 2016