Inclusion Criteria:

          -  Patients must be at least 18 years of age.

          -  Patients must have histologically confirmed diagnosis of Stege IV metastic melanoma
             positive for BRAF V600E mutation by either the COBAS test or other CLIA approved
             assay.

          -  Patients must have a ECOG performance status of 0 or 1.

          -  Patients must have the following hematologic, renal and liver function: absolute
             neutrophil count > 1500/mm3, platelets > 100,000/mm3, hemoglobin >9g/dL, creatinine ≤
             2 times the upper limits of normal (ULN), albumin > 2g/dL, total bilirubin ≤ 1.5
             mg/dl, ALT and AST ≤ 3 times above the upper limits of the institutional norm.

          -  Patients must be able to provide written informed consent.

          -  Negative serum pregnancy test within 7 days prior to commencement of dosing in
             premenopausal women. Women of non-childbearing potential may be included without serum
             pregnancy test if they are either sugically sterile or have been postmenopausal for ≥
             1 year.

        Fertile men and women must an effective method of contraception during treatment and for at
        least 6 months after completion of treatment as directed by their physician. Effective
        methods of contraception are defined as those which result in a low failure rate (i.e.,
        less than 1% per year) when used consistenly and correctly (for example implants,
        injectables, combined oral contraception or intra-uterine devices). At the discretion of
        the Investigator, acceptable methods of contraception may include total abstinence in cases
        where the lifestyle of the patient ensures compliance. (Periodic abstinence (e.g. calendar,
        ovulation, sympothermal, postovulation methods) with withdrawal are not acceptable methods
        of contraception.)

          -  Patients with treated brain metastases that have been stable for 1 month are eligible;
             patients must be off steroids for 1 week prior to starting study treatment.

          -  Any number and type of prior anticancer therapies except BRAF or MEK inhibitors.

          -  Patients must have discontinued active immunotherapy (IL-2, interferon, CTLA-4, etc.)
             or chemotherapy at least 4 weeks prior to entering the study and oral targeted therapy
             at least 2 weeks prior to entering the study and have recovered from adverse events
             due to those agents. Patients must not receive any other investigational anticancer
             therapy during the period on study or the four weeks prior to entry, with the
             exception of vaccines.

        Exclusion Criteria:

          -  Patients with serious concurrent infection or medical illness, which would jeopardize
             the ability of the patient to receive the treatment outlined in this protocol with
             reasonable safety.

          -  Patients who are pregnant and breast-feeding.

          -  Patients receiving concurrent therapy for their tumor (i.e.chemotherapeutics or
             investigational agents).

          -  Patients with leptomeningeal disease.

          -  Patients with a concurrent or prior malignancy within the last 2 years, unless they
             are patients with curatively treated carcinoma-in-situ, or basal cell carcinoma or
             squamous cell carcinoma of the skin. Patients with treated prostate cancer or breast
             cancer for which no concurrent therapy is indicated are eligible for this study.
             Patients who have been free of disease (any prior malignancy) for ≥ five years are
             eligible for this study.

          -  Due to risk of disease exacerbation patients with porphyria are not eligible.

          -  Due to risk of disease exacerbation patients with psoriasis are ineligible unless the
             disease is well controlled and they are under the care of a specialist for the
             disorder who agrees to monitor the patient for exacerbations.

          -  Patients receiving cytochrome P450 enzyme-inducing anticonvulsant drugs (EIADs) (i.e.
             phenytoin, carbamazepine, Phenobarbital, primidone, or oxcarbazepine) are ineligible.

          -  Patients with previously documented macular degeneration or diabetic retinopathy are
             ineligible.

          -  Patients with prior exposure to BRAF or MEK inhibitors are not eligible.

          -  Because patients witn immune deficiency are at increased risk of lethal infections
             when treated with bone marrow-suppressive therapy, HIV-positive patients are excluded
             from the study. For patients receiving combination anti-retroviral therapy, the
             potential impact of pharmacokinetic interactions with HCQ and VEM is unknown.
             Appropriate studies may be undertaken in patients with HIV and those receiving
             combination anti-retrovital therapy in the future.

          -  History of congenital long QT syndrome or a corrected QTc interval ≥ 450 msec at
             baseline.