Inclusion Criteria:

          1. Patients must be able to provide informed consent and be willing to sign an informed
             consent form;

          2. Patients must have an age ≥18 years;

          3. Patients must have a confirmed diagnosis of Polycythemia Vera according to the revised
             World Health Organization criteria;

          4. Patients must have mutated Janus Kinase 2 (mutation V617F) positive disease;

          5. Patients must have an active/not controlled disease defined as

               1. hematocrit ≥ 45% or hematocrit <45% in need of phlebotomy, and

               2. platelet count > 400 x109/L, and

               3. white blood cell count > 10 x109/L;

          6. Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1
             in Part A, ECOG performance status ≤ 2 in Part B within 7 days of initiating study
             drug;

          7. Female patient of childbearing potential has a negative serum or urine pregnancy test
             within 72 hours of the first dose of study therapy;

          8. Use of an effective means of contraception for women of childbearing potential and men
             with partners of childbearing potential;

          9. Adequate and acceptable organ function within 7 days of initiating study drug;

         10. Willingness and capability to comply with the requirements of the study.

        Note that if the enrolment in Part A is slow (i.e. < 5 patients enrolled in 3 months),
        eligibility for this part of the study may be expanded to all patients with chronic
        myeloproliferative neoplasms. In this case, the inclusion criteria 5 will be modified as
        following only for Part A:

        5. Patients must have an active/not controlled disease defined as:

          1. Essential Thrombocythemia patients: Platelet count > 600 x109/L;

          2. Myelofibrosis patients: no response according to European Myelofibrosis Network
             criteria.

        Exclusion Criteria:

          1. Active bacterial or mycotic infection requiring antimicrobial treatment;

          2. Pregnancy or nursing;

          3. A clinically significant corrected QT interval prolongation at baseline;

          4. Use of concomitant medications known to prolong the corrected QT interval;

          5. Clinically significant cardiovascular disease including:

               1. Uncontrolled hypertension despite medical treatment, myocardial infarction,
                  unstable angina within 6 months from study start;

               2. New York Heart Association Grade II or greater congestive heart failure;

               3. History of any cardiac arrhythmia requiring medication (irrespective of its
                  severity);

               4. A history of additional risk factors for torsade de pointes;

          6. Known positivity for human immunodeficiency;

          7. Known active hepatitis B virus and/or hepatitis C virus infection;

          8. Platelet count < 100 x109/L within 14 days before enrolment;

          9. Absolute neutrophil count < 1.2x109/L within 14 days before enrolment;

         10. Serum creatinine > 2 times the upper limit of normal;

         11. Total serum bilirubin > 1.5 times the upper limit of normal except in case of
             Gilbert's disease;

         12. Serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) > 3 times the
             upper limit of normal;

         13. History of other diseases (including active tumours), metabolic dysfunctions, physical
             examination findings, or clinical laboratory findings giving reasonable suspicion of a
             disease or condition that contraindicates use of an investigational drug or that might
             affect interpretation of the results of the study or render the subject at high risk
             from treatment complications;

         14. Prior treatment with a Janus Kinase 2 or Histone Deacetylase inhibitor or
             participation in an interventional clinical trial for chronic myeloproliferative
             neoplasms;

         15. Systemic treatment for chronic myeloproliferative neoplasms other than aspirin/cardio
             aspirin;

         16. Hydroxyurea within 28 days before enrolment;

         17. Interferon alpha within 14 days before enrolment;

         18. Anagrelide within 7 days before enrolment;

         19. Any other investigational drug or device within 28 days before enrolment;

         20. Patient with known hypersensitivity to the components of study therapy.