PRIMARY OBJECTIVES:
I. To evaluate the 6-month progression-free survival (PFS) rate of fibroblast growth factor
receptor 1 (FGFR1) amplified squamous cell lung cancer patients treated with BIBF 1120
(nintedanib).
SECONDARY OBJECTIVES:
I. Compare the 6-month PFS rate for the entire FGFR1 amplified group versus the FGFR1
non-amplified patients.
II. Compare the 6-month PFS rate for each FGFR1 amplified group (low, intermediate, and high)
versus historical controls and FGFR1 non-amplified patients.
III. To assess the following endpoints overall and by FGFR1 group: PFS, overall survival
(OS), confirmed tumor response rate, and adverse events.
TERTIARY OBJECTIVES:
I. The relation of FGFR1 gene copy number with PFS, OS, confirmed response rate, and adverse
events.
II. The relationship fibroblast growth factor receptor (FGFR) polymorphisms with toxicity and
efficacy.
OUTLINE:
Patients receive nintedanib orally (PO) twice daily (BID) on days 1-28. Courses repeat every
28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 8 weeks.
Inclusion Criteria:
- Patients with advanced histologically proven squamous cell carcinoma of the lung
- Patients who have failed at least 1 systemic chemotherapy regimen for metastatic
disease, but not more than 2 regimens
- Eastern Cooperative Oncology Group (ECOG) performance status of =< 1
- The pathologic tissue is available to determine FGFR1 amplification status
- Presence of either evaluable disease or measurable disease as defined by Response
Evaluation Criteria in Solid Tumors (RECIST) 1.1
- Absolute neutrophil count (ANC) >= 1500/uL
- Hemoglobin (HgB) >= 9 g/dL
- Platelets >= 100,000/uL
- Total bilirubin =< upper limit of normal (ULN)
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 1.5 x ULN (ALT
and AST =< 2.5 x ULN is acceptable if there is liver metastasis)
- Calculated or measured creatinine clearance >= 45 mL/min
- Patients of child-bearing potential must agree to use acceptable contraceptive methods
(e.g., double barrier) during treatment and have a negative serum or urine pregnancy
test done =< 7 days prior to registration (for women of childbearing potential only)
- Life expectancy >= 12 weeks
- Willingness to provide the blood specimens as required by the protocol; please note
that the willingness to participate pertains only to the patient and does not factor
in the institution's ability to participate in any part of the translational component
Exclusion Criteria:
- Patients with any known endothelial growth factor receptor (EGFR) mutation and/or
anaplastic lymphoma receptor tyrosine kinase (ALK) translocation
- Symptomatic, untreated, or uncontrolled central nervous system (CNS) metastases or
seizure disorder; patients with asymptomatic CNS metastases treated with whole brain
radiation (WBRT) or gamma knife radiosurgery (GKR) may be enrolled >= 1 week after
completion of WBRT/GKR provided toxicities are =< Common Toxicity Criteria (CTC) grade
I at the time of registration and/or controlled with dexamethasone 2 mg once daily for
at least 5 days at the time of study treatment; patients with symptomatic CNS
metastases treated with WBRT/GKR may be enrolled >= 2 weeks after completion of
WBRT/GKR provided toxicities are =< CTC grade 1 at the time of registration and
neurologic symptoms controlled with dexamethasone =< 2 mg once daily for at least 1
week at the time of study treatment
- Patients receiving palliative radiation to skeletal metastases may be registered as
early as 1 week after completion of radiation therapy provided toxicities are =< CTC
grade I at the time of registration
- Any of the following prior therapies for malignancy:
- Systemic chemotherapy =< 4 weeks prior to registration
- Radiation therapy =< 4 weeks prior to registration (exceptions noted in the prior
bullet); the site of previous radiotherapy should have evidence of progressive
disease if this is the only site of disease
- Major surgery (i.e., laparotomy), open biopsy, or significant traumatic injury =<
4 weeks prior to registration; minor surgery =< 2 weeks prior to registration;
insertion of a vascular access device is not considered major or minor surgery in
this regard
- Other investigational agent =< 30 days prior to study treatment
- The following patients will be excluded from this study:
- Pregnant women
- Breastfeeding women
- Men or women who are sexually active and unwilling to use a medically acceptable
method of contraception (e.g., such as implants, injectables, combined oral
contraceptives, some intrauterine devices or vasectomized partner for
participating females, condoms for participating males) during the trial and for
at least three months after end of active therapy; a highly effective method of
birth control is defined as one which results in a low failure rate (i.e., less
than 1% per year) when used consistently and correctly; patients will be
considered to be of childbearing potential unless surgically sterilized by
hysterectomy or bilateral tubal ligation/salpingectomy, or post-menopausal for at
least 2 years
- Second primary malignancy with the following exceptions which are allowed:
- Carcinoma in situ of the cervix
- Non-melanoma skin cancer
- History of low-grade (Gleason score =< 6) localized prostate cancer even if
diagnosed < 5 years prior to registration
- Treated stage I breast cancer even if diagnosed =< 5 years prior to registration
- Other prior malignancy (including melanoma) allowed if it was diagnosed and
definitively treated at least 5 years previously with no subsequent evidence of
recurrence
- Impairment of gastrointestinal function or gastrointestinal disease that may
significantly alter the absorption of BIBF 1120 (e.g., ulcerative disease,
uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or extensive small
bowel resection)
- Leptomeningeal disease
- Human immunodeficiency virus (HIV)-positive patients receiving combination
anti-retroviral therapy are excluded because of possible pharmacokinetic interactions
with oral investigational agents
- Unwilling to, or unable to, comply with the protocol
- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection requiring systemic antimicrobial therapy (including history of active or
chronic hepatitis C and/or hepatitis B infection), significant pulmonary symptoms at
baseline due to disease, symptomatic congestive heart failure, unstable angina
pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would
limit compliance with study requirements
- Centrally located tumors with radiographic evidence (computed tomography [CT] or
magnetic resonance imaging [MRI]) of local invasion of major blood vessels
- Significant weight loss (> 10% of baseline body mass) within past 6 months prior to
inclusion into the study
- Coagulation parameters: International normalized ratio (INR) > 2, prothrombin time
(PT) and partial thromboplastin time (PTT) > 50% of deviation of institutional ULN
- Proteinuria by Common Terminology Criteria for Adverse Events (CTCAE) grade 2 or
greater
- Known inherited predisposition to bleeding or thrombosis
- Therapeutic anticoagulation (except for low-dose heparin and/or heparin flush as
needed for maintenance of an in-dwelling intravenous device) or anti-platelet therapy
(except for low-dose therapy with acetylsalicylic acid < 325 mg per day)
- Baseline hemoptysis, per clinician/investigator evaluation
- Active alcohol or drug abuse
- History of arterial or venous thrombotic/embolic events =< 12 months prior to
registration
- Prior history with BIBF 1120 or any other vascular endothelial growth factor
(VEGF)/VEGF receptor (R) inhibitor
- New York Heart Association (NYHA) class III or IV; NOTE: patients classified as NYHA
class II controlled with treatment may participate, with increased monitoring
