Inclusion Criteria:

          -  Male or female at least 18 years of age at the time of signing the informed consent
             form.

          -  Provided signed written informed consent.

          -  Capable of compliance with the requirements and restrictions listed in the consent
             form.

          -  Body weight >=45 kilogram (kg) and a body mass index (BMI) >=19 Kilogram per meter
             squared (kg/m^2) and <40 kg/m^2 (inclusive).

          -  Able to swallow and retain oral medication.

          -  BRAF V600 mutation-positive tumor as confirmed in a Clinical Laboratory Improvement
             Amendments (CLIA)-approved laboratory or equivalent.

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

          -  Adequate baseline organ function defined in study protocol.

          -  Women of child-bearing potential must be willing to practice acceptable methods of
             birth control. Additionally, women of childbearing potential must have a negative
             serum pregnancy test within 14 days prior to the first dose of study medication.

        Exclusion Criteria:

          -  History of another malignancy with exceptions below, or any malignancy with confirmed
             activating RAS mutation. Exception: (a) Subjects who have been successfully treated
             and are disease-free for 5 years, (b) a history of completely resected non-melanoma
             skin cancer, (c) successfully treated in situ carcinoma, (d) CLL in stable remission,
             or (e) indolent prostate cancer (definition: clinical stage T1 or T2a, Gleason score
             <=6, and PSA <10 nanogram per milliliter [ng/mL]) requiring no or only anti-hormonal
             therapy, are eligible.

          -  Cancer therapy (chemotherapy with delayed toxicity, extensive radiation therapy,
             immunotherapy, biologic therapy, or major surgery) or investigational anti-cancer
             drugs within the last 3 weeks, or chemotherapy without delayed toxicity within the
             last 2 weeks, preceding the first dose of dabrafenib.

          -  Unresolved toxicity greater than Grade 2 from previous anti-cancer therapy except
             alopecia.

          -  Any serious and/or unstable pre-existing medical, psychiatric disorder or other
             conditions that could interfere with subject's safety, obtaining informed consent or
             compliance to the study procedures.

          -  Current use of therapeutic warfarin.

          -  Any prohibited medication(s) or herbal preparation as described in study protocol or
             requires any of these medications during the study.

          -  Have a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs
             chemically related to dabrafenib, rabeprazole and rifampin, or excipients that
             contraindicates their participation.

          -  Pregnant or nursing females.

          -  A history or evidence of cardiovascular risk including any of the following: a QT
             interval corrected for heart rate using the Bazett's formula (QTcB) >=480 milliseconds
             (msec); a history or evidence of current clinically significant uncontrolled
             arrhythmias; a history of acute coronary syndromes (including myocardial infarction or
             unstable angina), coronary angioplasty, or stenting within 6 months prior to
             randomization; a history or evidence of current >=Class II congestive heart failure
             (CHF) as defined by the New York Heart Association (NYHA) guidelines; Abnormal cardiac
             valve morphology (>=grade 2) documented by echocardiogram (subjects with grade 1
             abnormalities [i.e., mild regurgitation/stenosis] can be entered on study). Subjects
             with moderate valvular thickening should not be entered on study.

          -  Presence of active gastrointestinal (GI) disease or other condition (e.g., small bowel
             or large bowel resection) that will interfere significantly with the absorption of
             drugs. If clarification is needed as to whether a condition will significantly affect
             absorption of drugs, contact the GSK Medical Monitor.

          -  A history of known Human Immunodeficiency Virus (HIV), Hepatitis B Virus, or Hepatitis
             C Virus infection.

          -  Subjects with brain metastases are excluded if their brain metastases are:
             Symptomatic, Treated (surgery, radiation therapy) but not clinically and
             radiographically stable one month after local therapy, or asymptomatic and untreated
             but >1 centimeter (cm) in the longest dimension. Subjects with small (<=1 cm in the
             longest dimension), asymptomatic brain metastases that do not need immediate local
             therapy can be enrolled. Subjects on a stable dose of corticosteroids for >1 month, or
             those who have been off corticosteroids for at least 2 weeks can be enrolled. Subjects
             must also be off of enzyme-inducing anticonvulsants for more than 4 weeks.