Key Inclusion Criteria:

          -  Subjects must be at least 1 and less than or equal to 18 years of age at the time of
             study entry.

          -  Patients must have had histologic verification of one of the malignancies listed below
             at original diagnosis or at relapse - a) Rhabdomyosarcoma, b) Non-rhabdomyosarcomatous
             Soft Tissue Sarcoma (including desmoplastic small round cell tumor), c) Ewing Sarcoma
             / Peripheral Primitive Neuroectodermal Tumor (PNET), d) Osteosarcoma, e) Neuroblastoma
             (Measurable), f) Neuroblastoma (Evaluable), g) Hepatoblastoma.

          -  Patient must have disease that has either relapsed or is refractory to prior therap

          -  Patients who will be receiving the tablet formulation must have a body surface area
             (BSA) >= 0.84 m^2 (square meter) at baseline.

          -  Patients must have radiographically measurable disease (with the exception of
             neuroblastoma), Measurable disease is defined as the presence of at least one lesion
             on magnetic resonance imaging (MRI) or computed tomography (CT) scan that can be
             accurately measured with the longest diameter a minimum of 10 mm in at least one
             dimension (CT scan slice thickness no greater than 5 mm).

          -  Patients with neuroblastoma who do not have measurable disease but have iodine-131 -
             meta-iodobenzylguanidine positive (MIBG+) evaluable disease are eligible.

          -  Patients must have a Lansky or Karnofsky performance status score of >= 50,
             corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1 or 2. Use
             Karnofsky for subjects >= 16 years of age and Lansky for subjects <= 16 years of age.

          -  Patients must have fully recovered from the acute toxic effects of all prior
             chemotherapy, immunotherapy, or radiotherapy prior to entering this study.

          -  Patients must not have received myelosuppressive chemotherapy within 3 weeks of
             enrollment onto this study (6 weeks if prior nitrosourea).

          -  At least 7 days must have elapsed since the completion of therapy with a growth factor
             that supports platelet or white cell number or function. At least 14 days must have
             elapsed after receiving peg-filgrastim.

          -  At least 7 days must have elapsed since the completion of therapy with a biologic
             agent. For biologic agents that have known adverse events occurring beyond 7 days
             after administration, the period prior to enrollment must be extended beyond the time
             during which adverse events are known to occur.

          -  Subjects may have received bevacizumab, VEGF-Trap, or other VEGF blocking tyrosine
             kinase inhibitors, provided that they did not progress while receiving one of these
             agents. Subjects may not have previously received pazopanib.

          -  At least 21 days must have elapsed since the completion of the last dose of VEGF-Trap,
             and at least 7 days since a VEGF blocking tyrosine kinase inhibitor. Subjects must
             have recovered from any VEGF blocking drug-related toxicity (e.g., proteinuria).

          -  > = 21 days must have elapsed from infusion of last dose of antibody and toxicity
             related to prior antibody therapy must have recovered to Grade <= 1.

          -  Radiotherapy: >=2 weeks must have elapsed since local palliative radiotherapy (XRT)
             (small port); >=3 months must have elapsed if prior Traumatic Brain Injury (TBI),
             craniospinal XRT or if >=50% radiation of pelvis; >=6 weeks must have elapsed if other
             substantial bone marrow irradiation was given.

          -  No evidence of active graft versus host disease and >=2 months must have elapsed since
             transplant or rescue

          -  Adequate Bone Marrow Function defined as peripheral absolute neutrophil count (ANC)
             >=1000/ microlitre (µL), platelet count >= 75,000/µL (transfusion independent, defined
             as not receiving platelet transfusions within a 7 day period prior to enrollment); and
             hemoglobin >= 8.0 grams (g)/decilitre (dL), may receive red blood cell (RBC)
             transfusions. Subjects with bone marrow involvement will be eligible for study
             (provided they meet the criteria) but will not be evaluable for hematologic toxicity.

          -  Adequate Renal and Metabolic Function defined as creatinine clearance or radioisotope
             Glomerular filtration rate (GFR) >= 70 millilitre (mL)/ (min)/1.73 meter (m)^2 or A
             serum creatinine based on age/gender as follows, age 1 to < 2 years (male-0.6
             milligrams (mg)/dL, female-0.6 mg/dL), age 2 to < 6 years (male-0.8 mg/dL, female-0.8
             mg/dL), age 6 to < 10 years (male-1 mg/dL, female-1 mg/dL), age 10 to < 13 years
             (male-1.2 mg/dL, female-1.2 mg/dL), age 13 to < 16 years (male-1.5 mg/dL, female-1.4
             mg/dL), age >= 16 years (male-1.7 mg/dL, female-1.4 mg/dL), urine creatinine ratio of
             <1 or a urinalysis that is negative for protein; or, 24-hour urine protein level <
             1000 mg/dL, adequate thyroid function ,no more than Grade 1 abnormalities of
             potassium, calcium (confirmed by ionized calcium), magnesium and phosphorous.

          -  Adequate Liver Function defined as total bilirubin <=1.5 x upper limit of normal (ULN)
             for age, serum glutamic-pyruvic transaminase (SGPT) Alanine transaminase (ALT) <=2.5 x
             ULN (for the purpose of this study, the ULN for SGPT is 45 U/L), Serum albumin >=2
             g/dL. Must not have active liver or biliary disease (with the exception of Gilbert's
             syndrome or asymptomatic gallstones, liver metastases or otherwise stable chronic
             liver disease per investigator assessment). NOTE: Stable chronic liver disease should
             generally be defined by the absence of ascites, encephalopathy, coagulopathy,
             hypoalbuminaemia, oesophageal or gastric varices, persistent jaundice, or cirrhosis.
             No known positivity of hepatitis B surface antigen (HBsAg), or of positive hepatitis C
             antibody.

          -  Adequate Cardiac Function defined as shortening fraction of >=27% by echocardiogram
             (while not receiving medications for cardiac function), or ejection fraction of >= 50%
             by gated radionuclide study (while not receiving medications for cardiac function),
             the corrected QTc interval by Bazett's formula (QTcB) <450 milliseconds (msec), and
             must not have a history of myocardial infarction, severe or unstable angina,
             peripheral vascular disease or familial QTc prolongation.

          -  Adequate Blood Pressure Control defined as a blood pressure (BP) <= the 95th
             percentile for age, height, and gender measured, subjects on stable doses of no more
             than one anti-hypertensive medication, with a baseline BP <= 95th percentile for age,
             height and gender, will be eligible.

          -  Central Nervous System (CNS) Function defined as subjects with a known history of
             seizures must have well-controlled seizures and may not be receiving enzyme-inducing
             anti-convulsants, CNS toxicity <= Grade 2.

          -  Adequate Coagulation defined as prothrombin time (PT) and partial thromboplastin time
             (PTT) <= 1.2 x upper limit of normal and an international normalized ratio (INR) <=
             1.2.

        Key Exclusion Criteria:

          -  Pregnant or breast-feeding women are not eligible for this study due to risks of fetal
             and teratogenic adverse events as seen in animal/human studies. Negative pregnancy
             tests must be obtained in girls who are post-menarchal. Males or females of
             reproductive potential may not participate unless they have agreed to use an effective
             contraceptive method beginning at the signing of the informed consent until at least 2
             weeks after the last dose of the study drug. The definition of adequate contraception
             will be based on the judgment of the principal investigator or a designated associate.
             Study drug may also potentially be secreted in milk and therefore breastfeeding women
             are excluded.

        Males (including those who have had vasectomies) with partners who can become pregnant will
        need to use birth control while on this study, as will their partner. Men are advised to
        use condoms during sexual intercourse while on study drug and continue to use adequate
        contraception for at least 2 weeks after the last dose of protocol therapy.

          -  Patients requiring corticosteroids who have not been on a stable or decreasing dose of
             corticosteroid for the 7 days prior to enrollment are not eligible.

          -  Patients who are currently receiving another investigational drug are not eligible.

          -  Patients who are currently receiving other anti-cancer agents or radiation therapy are
             not eligible.

          -  Patients who are currently receiving more than one anti-hypertensive medication (Grade
             3) or whose blood pressure is not well controlled are not eligible for study
             enrollment.

          -  Patients must not be on therapeutic anticoagulation (Warfarin [coumadin] and/or low
             molecular weight heparin are prohibited). Prophylactic anticoagulation (i.e.
             intraluminal heparin) of venous or arterial access devices is allowed.

          -  Patients receiving drugs with a known risk of torsades de pointes are not eligible.

          -  Patients who require thyroid replacement therapy are not eligible if they have not
             been receiving a stable replacement dose for at least 4 weeks prior to study
             enrollment.

          -  Patients who are unable to swallow tablets or liquid are not eligible.

          -  Patients who have an uncontrolled infection are not eligible.

          -  Patients will be excluded if any of the following are present, evidence of active
             bleeding, intratumoral hemorrhage, or bleeding diathesis; History (within 6 months
             prior to study enrollment) of arterial thromboembolic events, including transient
             ischemic attack (TIA) or cerebrovascular accident (CVA); history (within 6 months
             prior to study enrollment) of pulmonary embolism, deep venous thrombosis (DVT), or
             other venous thromboembolic event; history of clinically significant bleeding within 6
             weeks prior to study enrollment.

          -  Patients with known involvement of the CNS by malignancy will be excluded.

          -  Patients who have had or are planning to have the following invasive procedures will
             be excluded- Major surgical procedure, laparoscopic procedure, open biopsy or
             significant traumatic injury within 28 days prior to Day 1 therapy (Subcutaneous port
             placement or central line placement is not considered major surgery but must be placed
             greater than 48 hours from planned Day 1 of therapy); Core biopsy within 7 days prior
             to Day 1 therapy; Fine needle aspirate or central line placement within 48 hours prior
             to Day 1therapy.

          -  Patients with serious or non-healing wound, ulcer, or bone fracture.

          -  History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
             within 28 days of study enrollment.

          -  Patients who in the opinion of the investigator may not be able to comply with the
             safety monitoring requirements of the study are not eligible.