Inclusion Criteria:

          -  Diagnosis of Stage IV Non-Small Cell Lung Cancer (NSCLC), or Stages II - III NSCLC
             that cannot be treated curatively with standard techniques.

          -  Non-Small Cell Lung Cancer (NSCLC) that is either EGFR or ALK mutated.

          -  Untreated with/or actively treated with specific inhibitor for less than 6 months if
             not progressing on active therapy.

          -  Age > 18.

          -  ECOG performance status 0, 1 or 2.

          -  Prior chemotherapy is allowed if > one month from the end of treatment. Patients must
             not have received chemotherapy within 4 weeks of the start of study drug.

          -  Brain metastases are allowed if the patient is asymptomatic or previous steroid
             treatment was discontinued > 6 weeks.

          -  Adequate bone marrow function as defined in the protocol

          -  Serum bilirubin levels < 1.5 mg/dL except for patients with Gilbert's syndrome.

          -  Adequate organ function as defined in the protocol

          -  If female and of childbearing potential, documentation of negative pregnancy test
             (serum or urine) within 7 days prior to first dose.

          -  Able to provide informed consent and have signed an approved consent form that
             conforms to federal and institutional guidelines.

        Exclusion Criteria:

          -  Concurrent therapy with any other non-protocol anti-cancer therapy.

          -  History of any other malignancy requiring active treatment.

          -  Patients who have had a history of acute diverticulitis, intra-abdominal abscess,
             Gastrointestical obstruction and abdominal carcinomatosis which are known risk factors
             for bowel perforation.

          -  History of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic
             progressive sclerosis [scleroderma], systemic lupus erythematosus, autoimmune
             vasculitis [e.g., Wegener's Granulomatosis]); motor neuropathy considered of
             autoimmune origin (e.g., Guillain-Barre Syndrome). History of vitiligo and adequately
             controlled endocrine deficiencies such as hypothyroidism are allowed.

          -  Significant cardiovascular disease including:

          -  Active, clinically symptomatic left ventricular failure.

          -  Uncontrolled symptomatic hypertension that cannot be controlled with anti-hypertensive
             agents.

          -  Myocardial infarction, severe angina, or unstable angina within 6 months prior to
             administration of first dose of study drug.

          -  History of serious ventricular arrhythmia (i.e., ventricular tachycardia or
             ventricular fibrillation)

          -  Cardiac arrhythmias requiring anti-arrhythmic medications (except for atrial
             fibrillation that is well controlled with anti-arrhythmic medication)

          -  Coronary or peripheral artery bypass graft within 6 months of screening.

          -  Uncontrolled CNS metastases are not allowed; subjects with previously treated brain
             metastases will be allowed if the brain metastases have been treated, toxicities have
             resolved to grade 1 or baseline and steroids are no longer required. Leptomeningeal
             metastases are not allowed.

          -  Serious/active infection or infection requiring parenteral antibiotics.

          -  Pregnant or lactating females.

          -  HIV infection or chronic hepatitis B or C. Negative Screening tests for HIV, Hepatitis
             B, and Hepatitis C are required.

          -  The presence of any other medical or psychiatric disorder that, in the opinion of the
             treating physician, would contraindicate the use of the drugs in this protocol or
             place the subject at undue risk for treatment complications.