Inclusion Criteria:

          -  Germline mutation in BRCA1 or BRCA2 that is predicted to be deleterious or suspected
             deleterious.

          -  Histologically or cytologically confirmed breast cancer with evidence of metastatic
             disease.

          -  Prior therapy with an anthracycline and a taxane in either an adjuvant or metastatic
             setting.

          -  Prior platinum allowed as long as no breast cancer progression occurred on treatment
             or if given in adjuvant/neoadjuvant setting at least 12 months from last dose to study
             entry elapsed.

          -  ER/PR breast cancer positive patients must have received and progressed on at least
             one endocrine therapy (adjuvant or metastatic), or have disease that the treating
             physician believes to be inappropriate for endocrine therapy.

          -  ECOG performance status 0-1.

          -  Adequate bone marrow, kidney and liver function.

        Exclusion Criteria:

          -  Prior treatment with PARP inhibitor.

          -  Patients with HER2 positive disease.

          -  More than 2 prior lines of chemotherapy for metastatic breast cancer.

          -  Untreated and/or uncontrolled brain metastases.

          -  Prior malignancy unless curatively treated and disease-free for > 5 years prior to
             study entry. Prior adequately treated non-melanoma skin cancer, in situ cancer of the
             cervix, DCIS or stage I grade 1 endometrial cancer allowed.

          -  Known HIV (Human Immunodeficiency Virus) infection.

          -  Pregnant or breast-feeding women.