- Inclusion Criteria:

        A patient will be considered for enrollment in this study if all of the following criteria
        are met:

          1. Female patients ≥18 years of age.

          2. Have either:

               1. locally advanced TNBC defined as invasive ductal cancer; ER- tumors with <10% of
                  tumor nuclei immunoreactive; PR- tumors with <10% of tumor nuclei immunoreactive;
                  T3 or T4 disease, regardless of nodal status (T2 disease is eligible if there are
                  positive lymph nodes present by physical exam or imaging evaluation or
                  histological evaluation, OR

               2. High-risk ER+ breast cancer defined as grade 3 invasive ductal or mixed
                  ductal/lobular cancers, or grade 2 with Ki67 ≥20%; node positive as evidenced by
                  physical exam or imaging evaluation or histological evaluation.

          3. HER2- negative breast cancer. If HER2-, it is defined as follows:

               1. FISH-negative (FISH ratio <2.0), or

               2. IHC 0-1+, or

               3. IHC 2+ AND FISH-negative (FISH ratio<2.0)

          4. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1

          5. Adequate hematologic function, defined by:

               1. Absolute neutrophil count (ANC) >1500/mm3

               2. Platelet count ≥100,000/mm3

               3. Hemoglobin >9 g/dL (in the absence of red blood cell transfusion)

          6. Adequate liver function, defined by:

               1. AST and ALT ≤2.5 x the upper limit of normal (ULN)

               2. Total bilirubin ≤1.5 x ULN

          7. Adequate renal function, defined by:

             a. Serum creatinine ≤1.5 x ULN or calculated creatinine clearance of ≥60 ml/min

          8. Patients with previous history of invasive cancers (including breast cancer) are
             eligible if definitive treatment was completed more than 5 years prior to initiating
             current study treatment, and there is no evidence of recurrent disease.

          9. Eligible for treatment with paclitaxel, doxorubicin, cyclophosphamide and
             carboplatine.

         10. Patient must be accessible for treatment and follow-up.

         11. Patients must be willing to undergo research biopsies to obtain breast cancer tissue
             for whole exome sequencing and evaluation of tumor immune microenvironment.

         12. All patients must be able to understand the investigational nature of the study and
             give written informed consent prior to study entry.

               -  Exclusion Criteria:

        A patient will be ineligible for inclusion in this study any of the following criteria are
        met:

          1. Evidence of metastatic disease on bone scan and CT scan of chest/abdomen (or PET CT
             scan). Patients with intrathoracic metastatic adenopathy are eligible.

          2. Active infection or unexplained fever >38.5°C during screening.

          3. Active infections including viral hepatitis and HIV.

          4. Active asthma or other condition requiring steroid therapy.

          5. Autoimmune disease including lupus erythematosus or rheumatoid arthritis. Topical or
             inhaled corticosteroids are allowed.

          6. Patients who are currently receiving or who have received previous systemic therapy
             for breast cancer (eg, chemotherapy, antibody therapy, targeted agents).The use of an
             LHRH agonist during chemotherapy in premenopausal women who wish to preserve ovarian
             function is allowed, but is not required.

          7. Women who are pregnant or lactating. All patients with reproductive potential must
             agree to use effective contraception from time of study entry until at least 3 months
             after the last administration of study drug.

          8. Have a NYHA Class III or IV CHF or LVEF <55%. Patients with significant cardiac
             disease history within 1 year or ventricular arrhythmias requiring medication are also
             excluded.

          9. Patients who have any severe and/or uncontrolled medical conditions or other
             conditions that could affect their participation such as:

               1. severe impaired lung functions as defined as spirometry and DLCO that is 50% of
                  the normal predicted value and/or O2 saturation that is 88% or less at rest on
                  room air

               2. uncontrolled diabetes as defined by fasting serum glucose >1.5 x ULN

               3. liver disease such as cirrhosis or severe hepatic impairment (Child-Pugh class
                  C).

         10. History of any other disease, physical examination finding, or clinical laboratory
             finding giving reasonable suspicion of a disease or condition that contraindicates use
             of an investigational drug, or that might affect interpretation of the results of this
             study, or render the patient at high risk for treatment complications.

         11. Any other investigational or anti-cancer treatments while participating in this study.

         12. Any other cancer