-  INCLUSION CRITERIA

        2.1.1.1 Patients must have histologically or cytologically confirmed papillary RCC.

          1. Patients with bilateral multifocal disease can have tumors localized to the kidney or
             have metastatic disease

          2. Patients with sporadic papillary RCC (but without multifocal disease) should have
             advanced disease that is considered unresectable

        2.1.1.2 Patients must have measurable disease, defined as at least one lesion that can be
        accurately measured in at least one dimension (longest diameter to be recorded for nonnodal
        lesions and short axis for nodal lesions). Nodal lesions must be (Bullet) 15mm by CT scan
        or MRI. Non nodal lesions must be >10 mm with CT scan or MRI.

        2.1.1.3 Patients must have normal organ and marrow function as defined below:

          -  Hemoglobin > 9 g/dL (SI Units: 90 g/L)

          -  Platelet count greater than or equal to 75 x 10 (9)/L

          -  Absolute neutrophil count (ANC) greater than or equal to 1.5 x 10(9)/L without growth
             factor support

          -  Total bilirubin less than or equal to 2 x upper limit of normal (ULN)

          -  AST/SGOT and/or ALT/SGPT less than or equal to 2.5 x upper limit of normal (ULN)

          -  Serum creatinine less than or equal to 1.5 x ULN

          -  Asymptomatic serum amylase less than or equal to 2 x ULN; patients with > ULN but less
             than or equal to 2 x ULN serum amylase at study start must be confirmed to have no
             signs and/or symptoms suggestion pancreatitis or pancreatic injury ( e.g. elevated
             P-amylase, abnormal imaging findings of pancreas, etc.)

          -  Serum lipase less than or equal to ULN

          -  Fasting serum triglyceride level less than or equal to 500 mg/dL

        2.1.1.4 Patients may have had no more than 3 prior lines of systemic therapy. Prior therapy
        with a MET inhibitor is allowed as long as the patient has not had progressive disease
        while receiving the agent

        2.1.1.5 Patient must be able to swallow and retain oral medication

        2.1.1.6 Age greater than or equal to18 years.

        2.1.1.7 ECOG performance status 0 - 2.

        2.1.1.8 Patients must provide written informed consent prior to any study procedures.

        2.1.1.9 Patients must be willing and able to comply with scheduled visits, treatment plan
        and laboratory tests

        EXCLUSION CRITERIA

        2.1.2.1 Patients who are receiving any other investigational agents for treatment of their
        kidney cancer.

        2.1.2.2 History of allergic reactions attributed to compounds of similar chemical or
        biologic composition to INC280. Excipients in the current formulation include
        microcrystalline cellulose, mannitol, sodium starch glycolate, magnesium stearate and
        colloidal silicon dioxide

        2.1.2.3 Uncontrolled intercurrent illness including, but not limited to, ongoing or active
        infection requiring intravenous antibiotics, symptomatic congestive heart failure, unstable
        angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would
        limit compliance with study requirements or potentially affect the interpretation of study
        data.

        2.1.2.4 Subjects with significant or uncontrolled cardiovascular disease (e.g.,
        uncontrolled hypertension, peripheral vascular disease, congestive heart failure, cardiac
        arrhythmia, or acute coronary syndrome) within 6 months prior to starting study treatment
        or heart attack within 12 months prior to starting study treatment

        2.1.2.5 Patients receiving any medications that are known to be strong inducers or
        inhibitors of CYP3A4, or sensitive substrates of CYP3A4, CYP1A2, CYP2C9, CYP2C9, CYP2C19 or
        P-gp with a narrow therapeutic index.

        2.1.2.6 Symptomatic CNS metastases that are neurologically unstable or requiring > 5 mg/day
        of dexamethasone (or equivalent) to control CNS disease.

        Note: Patients with controlled CNS metastases are allowed. Radiotherapy or surgery for CNS
        metastases must have been completed >2 weeks prior to study entry. Patients must be
        neurologically stable, having no new neurologic deficits on clinical examination, and no
        new findings on CNS imaging. Steroid use for management of CNS metastases must be at a
        stable dose for two weeks preceding study entry.

        2.1.2.7 Patients with greater than or equal to Grade 2 neuropathy.

        2.1.2.8 Treatment with proton pump inhibitors within 3 days prior to study entry. If
        continued use of GI prophylaxis is required, the patient will be switched to an appropriate
        H2 antagonist with appropriate counsel and caution.

        2.1.2.9 Currently receiving any prohibited medications including vitamins and herbal
        Supplements.

        2.1.2.10 Major surgery within 4 weeks prior to initiating treatment, excluding the
        placement of vascular access.

        2.1.2.11 The subject has not recovered to baseline, CTCAE less than or equal to Grade 1
        from toxicity due to all prior therapies for RCC or to a level permitted under other
        sections of the eligibility criteria except alopecia and other non-clinically significant
        AEs.

        2.1.2.12 Any other condition that would, in the Investigator s judgment, contraindicate
        participation in the clinical study due to safety concerns or compliance with clinical
        study procedures, e.g., infection/inflammation, intestinal obstruction, unable to swallow
        medication, social/ psychological issues, etc.

        2.1.2.13 Pregnant or nursing (lactating) women, where pregnancy is defined as the state of
        a female after conception and until the termination of gestation, confirmed by a positive
        hCG laboratory test (> 30 mIU/mL). Laboratory values >5 mIU/mL, but <30 mIU/mL should be
        repeated in 48 hours.

        2.1.2.14 Women of child-bearing potential, defined as all women physiologically capable of
        becoming pregnant, unless they are using highly effective methods of contraception during
        dosing and for 3 month days after stopping study drug. Highly effective contraception
        methods include:

          -  Total abstinence or

          -  Male or female sterilization or

          -  Combination of any two of the following (a+b or a+c or b+c):

               1. Use of oral, injected or implanted hormonal methods of contraception

               2. Placement of an intrauterine device (IUD) or intrauterine system (IUS)

               3. Barrier methods of contraception: condom or occlusive cap (diaphragm or
                  cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal suppository
                  Women are considered post-menopausal and not of child bearing potential if they
                  have had 12 months of natural (spontaneous) amenorrhea with an appropriate
                  clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have
                  had surgical bilateral oophorectomy (with or without hysterectomy) or tubal
                  ligation at least six weeks ago. In the case of oophorectomy alone, only when the
                  reproductive status of the woman has been confirmed by follow up hormone level
                  assessment is she considered not of child bearing potential.

        2.1.2.15 Sexually active males must use a condom during intercourse while taking the drug
        and for 3 months after stopping study drug and should not father a child in this period. A
        condom is required to be used also by vasectomized men in order to prevent delivery of the
        drug via seminal fluid.

        2.1.2.16 HIV-positive patients on combination antiretroviral therapy are ineligible because
        of the potential for pharmacokinetic interactions with INC280.

        2.1.2.17 Prior invasive malignancy of other histology currently requiring treatment.