Inclusion Criteria:

          -  Patients with radiographically proven recurrent, intracranial high grade glioma will
             be eligible for this protocol. Patients must have evidence of tumor progression as
             determined by the Revised Assessment in Neuro-Oncology RANO criteria following
             standard therapy.

          -  High grade glioma includes glioblastoma multiforme (GBM), Gliosarcoma (GS), anaplastic
             astrocytoma (AA), anaplastic oligodendroglioma (AO), anaplastic mixed oligoastrocytoma
             (AMO), or malignant astrocytoma not otherwise specified. (NOS)

          -  Magnetic resonance imaging (MRI) must be performed within 21 days prior to enrollment,
             and patients who are receiving steroids must be stable or decreasing for at least 5
             days prior to imaging. If the steroid dose is increased between the date of imaging
             and enrollment, a new baseline MRI is required.

          -  Patients must have completed only 1 prior course of radiation therapy and must have
             experienced an interval of greater than 12 weeks from the completion of radiation
             therapy to study entry.

          -  Patients will be eligible if the original histology was low-grade glioma and a
             subsequent histological diagnosis of a high grade glioma is made.

          -  There is no limit as to the number of prior treatments but patients must have
             radiographic evidence of progressive disease

          -  Recurrent tumor must be a solid, single, supratentorial, contrast-enhancing HGG which
             have a tumor diameter no larger than 4cm or volume of 34cm3

          -  All patients must sign an informed consent indicating that they are aware of the
             investigational nature of this study. Patients must be registered prior to treatment
             with study drug.

          -  Patients must be> 18 years old, and with a life expectancy > 8 weeks

          -  Patients with Karnofsky performance status of > 70.

          -  At the time of registration: Patients must have recovered from the toxic effects of
             prior therapy: > 10 days from any noncytotoxic investigational agent, >28 days from
             prior cytotoxic therapy or Avastin, >14 days from vincristine, >42 days from
             nitrosoureas, >21 days from procarbazine administration, and >7 days for non-cytotoxic
             agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc.
             (radiosensitizer does not count). Any questions related to the definition of
             non-cytotoxic agents should be directed to the Study Chair.

          -  requirements for organ and marrow function as follows:

          -  Adequate bone marrow function:

          -  leukocytes > 3,000/microliter (mcL)

          -  absolute neutrophil count > 1,500/mcL

          -  platelets > 100,000/mcL

          -  Adequate hepatic function:

          -  total bilirubin within normal institutional limits

          -  aspartate aminotransferase (AST) < 2.5 X institutional upper limit of normal

          -  alanine aminotransferase (ALT) < 2.5 X institutional upper limit of normal

          -  Adequate renal function:

          -  creatinine within normal institutional limits OR

          -  creatinine clearance > 60 mL/min/1.73 m2 for patients with creatinine levels above
             institutional normal

          -  The effects of nano liposomal irinotecan on the developing human fetus are unknown.
             For this reason, women of child-bearing potential and men must agree to use adequate
             contraception: hormonal or barrier method of birth control; abstinence, etc. prior to
             study entry, for the duration of study participation, and for 6 months post drug
             administration. Should a woman become pregnant or suspect she is pregnant while she or
             her partner is participating in this study, she should inform her treating physician
             immediately

          -  Women of childbearing potential must have a negative beta-human chorionic gonadotropin
             (beta-HCG) pregnancy test documented within 14 days prior to treatment.

          -  Patients with prior therapy that included interstitial brachytherapy, or Gliadel
             wafers must have confirmation of true progressive disease rather than radiation
             necrosis based upon either Positron Emission Tomography (PET) or Thallium scanning, MR
             spectroscopy or surgical documentation of disease

          -  Patients must be able to have MRI brain imaging.

          -  Patients must not have any significant medical illnesses that in the investigator's
             opinion cannot be adequately controlled with appropriate therapy or would compromise
             the patient's ability to tolerate this therapy

          -  Patients with a history of any other cancer (except non-melanoma skin cancer or
             carcinoma in-situ of the cervix), unless in complete remission and off of all therapy
             for that disease for a minimum of 3 years are ineligible.

          -  Patients must not have an active infection or serious intercurrent medical illness.

          -  Patients must not be pregnant/breast feeding and must agree to practice adequate
             contraception.

          -  HIV-positive patients on combination antiretroviral therapy are ineligible

          -  Contrast-enhancing tumor which crosses the midline.

          -  Multi-focal disease

          -  Nonparenchymal tumor dissemination (e.g., subependymal or leptomeningeal)

          -  History of hypersensitivity reactions to products containing irinotecan (irinotecan),
             topotecan or other topoisomerase inhibitors, gadolinium contrast agents or lipid
             products

          -  Ongoing treatment with cytotoxic therapy

          -  Patients may not be on an enzyme-inducing anti-epileptic drug (EIAED). If previously
             on an EIAED, patient must be off for at least 10 days prior to CED infusion.