1. Progression free survival rate at 12 weeks, defined as the proportion of patients alive
and progression free at Week 12. Patients will be progression free if they have no tumor
assessments of progressive disease (defined according to RECIST guidelines, version 1.1)
at any point from the start of treatment to Week 12.
2. Objective response rate (ORR), defined as the proportion of patients whose best overall
response is either CR or PR according to RECIST version 1.1. The best overall response
is the best response recorded during the first 12 week treatment cycle.
3. Disease control rate (DCR), defined as the proportion of patients with a documented CR,
PR and SD during the first 12 week treatment cycle according to RECIST version 1.1.
4. Duration of overall tumor response (DR), defined as the interval between the date of the
first observation of tumor response (CR or PR) and the date of disease progression or
death.
5. Progression free survival defined as the time from randomization to objective tumor
progression by RECIST version 1.1 or death due to any cause, whichever occurs first.
6. Overall survival (OS) defined as the time from randomization to death from any cause.
7. Time to progression (TTP) defined as the time from randomization to objective tumor
progression by RECIST version 1.1.
Inclusion Criteria:
- Cytologically or histologically confirmed non squamous NSCLC Stage IV (including
pleural effusion).
- Radiologically confirmed disease progression following two previous lines of
anti-cancer therapy, one of which should be a platinum based regimen, OR the patient
has refused treatment with approved treatment modalities
- At least one radiologically measurable target lesion per RECIST version 1.1
- Fresh or archival biopsy tissue available to determine tumor mutation status
- Written informed consent that is consistent with International Conference on
Harmonisation Tripartite Guideline on Good Clinical Practice guidelines
- Patient or legally acceptable representative has granted written informed consent
before any study specific procedures (including special Screening tests) are performed
- Eastern Cooperative Oncology Group (ECOG) performance score of 0, 1 or 2
- Hemoglobin ≥ 9.0 g/dL; platelets ≥ 100 x 109/L; absolute neutrophil count ≥ 1.5 x
109/L without the use of hematopoietic growth factors
- Bilirubin and creatinine less than 2 × upper limit of normal (ULN) for the institution
- Albumin ≥ 2.5 mg/dL
- Aspartate aminotransferase and alanine aminotransferase less than 5 × ULN for the
institution
- Prothrombin time less than 1.5 × ULN for the institution
- Potassium, magnesium and phosphorus within the normal range for the institution
(supplementation is permissible)
- Recovery to Grade 1 or baseline of any toxicities due to prior treatments, excluding
alopecia
Exclusion Criteria:
- Chemo-, hormone- or immunotherapy, within 4 weeks or within less than four half lives
of the date of first administration of study drug and/or persistence of toxicities of
prior anti-cancer therapies which are deemed to be clinically relevant
- Radiotherapy within the past 2 weeks prior to date of first administration of study
drug
- Previous treatment with an histone deacetylase inhibitor or an epidermal growth factor
receptor inhibitor within at least 4 weeks of the date of first administration of
study drug
- Treatment with any drug(s) known to be an inhibitor or inducer of cytochrome P450
(CYP)2C19, CYP3A4, CYP2C8, and CYP2E1, within 14 days of the date of first
administration of study drug
- Brain metastases, which are symptomatic; patients with treated, brain metastases are
eligible with stable brain disease for at least 4 weeks without the requirement for
steroids or anti epileptic therapy
- Inability to swallow oral medications or a recent acute gastrointestinal disorder with
diarrhea e.g., Cohn's disease, malabsorption, or Common Terminology Criteria for
Adverse Event (CTCAE) Grade > 2 diarrhea of any etiology at baseline
- Other malignancies diagnosed within the past five years (other than curatively treated
cervical cancer in situ), non melanoma skin cancer, superficial bladder tumors Ta (non
invasive tumor) and TIS (carcinoma in situ)
- Patients with any serious active infection (i.e., requiring an intravenous antibiotic,
antifungal, or antiviral agent)
- Patients with known human immunodeficiency virus, active hepatitis B or active
hepatitis C
- Patients who have any other life threatening illness or organ system dysfunction,
which in the opinion of the investigator, would either compromise patient safety or
interfere with the evaluation of the safety of the study drug
- Known or suspected substance abuse or alcohol abuse
- Pregnancy or breast feeding
- History of clinically significant or uncontrolled cardiac disease, including
congestive heart failure, angina, myocardial infarction, arrhythmia, including New
York Heart Association functional classification of three
