Inclusion Criteria:

          -  All patients must have the ability to understand and the willingness to sign a written
             informed consent

          -  Life expectancy of greater than 3 months by physician assessment

          -  Eastern Cooperative Oncology Group (ECOG) performance status =< 2

          -  Patients must have histologically or cytologically confirmed (at original diagnosis or
             subsequent recurrence or progression) solid tumor that is metastatic, unresectable,
             progressive, or recurrent, and for which standard curative or palliative measures do
             not exist or are no longer effective

          -  Patients must have measurable or evaluable disease

          -  Patients must not have received prior chemotherapy or radiation for < 4 weeks prior to
             start of study treatment

          -  Patients may be entered if they have received prior radiation therapy involving =< 30%
             of the bone marrow; any prior radiation therapy must have been administered >= 4 weeks
             prior to start of study treatment and the patient must be recovered from the acute
             toxic effects of the treatment prior to start of study treatment

          -  Patients may be enrolled with a history of treated brain metastases that are
             clinically stable for >= 4 weeks prior to start of study treatment

          -  Women of child-bearing potential and men must agree to use adequate contraception
             (hormonal or barrier method of birth control or abstinence) prior to study entry and
             for six months following duration of study participation; women of child-bearing age
             will undergo urine pregnancy testing prior to study enrollment; should a woman become
             pregnant or suspect that she is pregnant while participating on the trial, she should
             inform her treating physician immediately

          -  Active breast-feeding is also not allowed on study enrollment

          -  Leukocytes >= 3,000 cells/µL

          -  Absolute neutrophil count >= 1,500 cells/µL

          -  Platelets >= 100, 000 cells/µL

          -  Total bilirubin =< 1.5 times the upper limit of normal (ULN)

          -  Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN; AST/ALT
             =< 5 x ULN if liver metastasis is present

          -  Serum creatinine =< 1.5 mg/dL or a measured creatinine clearance >= 50 mL/min

          -  Prothrombin time (PT)/international normalized ratio (INR)/ activated partial
             thromboplastin time (aPTT) =< 1.5 x ULN

          -  Negative serum beta-human chorionic gonadotropin (HCG) test (female patient of
             childbearing potential only)

        Exclusion Criteria:

          -  Patients may not be receiving any other investigational agents; use of
             over-the-counter herbal medications will also be excluded

          -  Patients with uncontrolled undercurrent illness including, but not limited to, ongoing
             or active infection, or psychiatric illness/social situations that would limit
             compliance with study requirements

          -  Patients unable or unwilling to swallow pills

          -  Active heart disease including myocardial infarction within previous 3 months,
             symptomatic coronary artery disease or heart block, or uncontrolled congestive heart
             failure

          -  Patients with a history of noninfectious pneumonitis will be excluded during the
             dose-escalation phase of the trial

          -  Patients, who in the opinion of the investigator and another independent party, may
             not be able to adhere to the safety monitoring requirements of the study