Inclusion Criteria:

        (1)18 to 65 years old,male or female (2)Pathologically or cytologically proven thoracic
        middle-lower esophageal squamous cell carcinoma; (3)clinical stage II or stage III;
        (4)Primary tumors can be measured; (5)Karnofsky score >70; (6)Estimated life expectancy of
        at least 12 weeks; (7)reproductive age women should ensure that before entering the study
        period contraception; (8)Hemoglobin≥90.0g/dL,white blood cell count（WBC）≥ 4000
        cells/mm³,Platelet count≥100,000 cells/mm³; (9)Aspartate aminotransferase (AST) and alanine
        aminotransferase (ALT) < 2.5 times upper limit of normal,bilirubin normal; (10)Creatinine
        normal OR creatinine clearance ≥ 60 mL/min; (11)Patients have good compliance to treatment
        and follow-up of acceptance; (12)Forced expiratory volume in one second（FEV1） ≥ 1.5 litre
        or ≥ 75% of the reference value; (13)Considered operable (i.e. appropriate organ functions
        and ability to undergo general anesthesia); (14)No severe or uncontrolled cardiovascular
        disease; (15)No active uncontrolled infection;

        Exclusion Criteria:

          1. Patient who have distant metastasis

          2. The primary tumor or lymph node already received surgical treatment (except for
             biopsy);

          3. Patient who received radiotherapy for primary tumor or lymph node;

          4. Patient who received the the epidermal growth factor targeted therapy;

          5. Patient who received chemotherapy or immunotherapy;

          6. Patient who suffered from other malignant tumor;

          7. Epidermal growth factor receptor（EGFR）mutation（-）;

          8. Patient who have taken other drug test within 1 month;

          9. Pregnant woman or Lactating Women and Women in productive age who refuse to take
             contraception in observation period;

         10. Subject with a severe allergic history or idiosyncratic;

         11. Subject with severe pulmonary and cardiopathic disease history; Refuse or incapable to
             sign the informed consent form of participating this trial;

         12. Drug abuse or alcohol addicted;

         13. Subject with a Personality or psychiatric diseases, people with no legal; capacity or
             people with limited capacity for civil conduct;