Inclusion Criteria:

          -  Written informed consent must be obtained prior to any screening procedures

          -  Phase I: Patients with advanced/metastatic solid tumors, with measurable or
             non-measurable disease as determined by modified RECIST version 1.1 who have
             progressed despite standard therapy or be intolerant of standard therapy, or for whom
             no standard therapy exists, who have tumors harboring one of the following: confirmed
             PIK3CA mutation or amplification, PTEN loss of function, EGFR mutation, cMET
             activation and/or HER2 overexpression. Endometrial carcinoma will not be selected for
             any molecular status.

          -  Phase II: Patients with advanced/metastatic solid tumors, with at least one measurable
             lesion as determined by modified RECIST version 1.1, who progressed despite standard
             therapy or be intolerant of standard therapy, or for whom no standard therapy exists,
             fitting in one of the following groups: Group 1: patients with PIK3CA mutated or
             amplified ER positive (ER+) breast cancer ; Group 2: patients with endometrial
             carcinoma (not selected for any molecular status); Group 3: patients with solid tumors
             (with the exception of PIK3CA mutant/amplified ER+ breast cancer and endometrial
             carcinoma) harboring PIK3CA mutation or amplification/any PTEN status; Group 4:
             patients with solid tumors (with the exception of endometrial carcinoma) harboring
             PTEN loss of function/ PIK3CA wild type; Group 5: non-small cell lung cancer harboring
             cMET activation and/or EGFR mutation. Up to 3 lines of chemotherapy allowed in
             advanced/metastatic setting.

          -  ECOG Performance Status ≤ 2.

          -  Availability of a representative formalin fixed paraffin embedded tumor tissue sample.
             If archival tumor sample is not available, a newly obtained tumor sample needs to be
             submitted instead.

        Exclusion Criteria:

          -  Brain metastasis unless treated and neurologically stable

          -  Patient having out of range laboratory values defined as:

        Hepatic and renal function:

          -  Serum total Bilirubin ≥ 1.5 x ULN (upper limit of normal) or aspartate
             aminotransferase (AST) or alanine aminotransferase (ALT) ≥ 2.5 x ULN

          -  For patients with tumor involvement of the liver AST or ALT > 5 x ULN

          -  For patients with Gilbert's syndrome total bilirubin > 2.5 x ULN

          -  Serum creatinine > 1.5 x ULN and/or measured or calculated creatinine clearance < 75%
             LLN (lower limit of normal)

        Bone marrow function:

          -  Platelets < 100 x 109/L

          -  Hemoglobin (Hgb) < 9 g/dL

          -  Absolute Neutrophil Count (ANC) < 1.5 x 109/L

        Cardiac function:

          -  Clinically significant and/or uncontrolled heart disease such as congestive heart
             failure (CHF) requiring treatment (NYH grade ≥2), hypertension or arrhythmia

          -  Left ventricular ejection fraction (LVEF) < 45% as determined by MUGA scan or ECHO

          -  QTcF >480 msec on screening ECG or congenital long QT syndrome

          -  Acute myocardial infarction (AMI) or unstable angina pectoris < 3 months prior to
             study entry

               -  Peripheral neuropathy CTCAE Grade ≥2

               -  History of pancreatitis of any grade

               -  Patients with diabetes mellitus requiring insulin treatment and/or with clinical
                  signs or with Fasting Plasma Glucose (FPG) ≥ 140 mg/dL / 7.8 mmol/L

               -  Patients receiving treatment with medications that are known to be 1) strong
                  inhibitors or inducers of CYP3A4/5; 2) CYP2C9 substrate with narrow therapeutic
                  index; 3) QT prolonging agents; 4) proton pump inhibitors unless these
                  medications can be discontinued at least a week prior to start of treatment.

        Other protocol-defined inclusion/exclusion criteria may apply.