Inclusion Criteria:

          -  Acute lymphoblastic leukemia, excluding known mature B-cell ALL by the presence of any
             of the following: surface immunoglobulin, L3 morphology, t(8;14)(q24;q32), t(8;22), or
             t(2;8).

          -  Patients with mature B-cell ALL will be removed from the protocol as soon as that
             diagnosis is made and should be treated on a B-cell leukemia (Burkitt's) protocol.
             NOTE: Patients with T-cell surface markers and a t(8;14)(q24;q11) remain eligible.

          -  Patients with lymphoblastic lymphoma are also eligible

          -  No prior anti-leukemic therapy except the following are allowed: <1 week of
             corticosteroids, or hydroxyurea or emergent leukopheresis. Longer steroid use for
             diseases other than leukemia is permitted.

          -  Age 51- 75 years

          -  Voluntary written consent must be given before performance of any study-related
             procedures not part of standard medical care, with the understanding that consent may
             be withdrawn by the patient at any time without prejudice to future medical care.

          -  If patient is known to be HIV positive, they will not be eligible for the protocol.
             HIV testing is not mandatory prior to protocol enrollment.

          -  Patients whose comorbid medical condition, in the investigator's opinion, would make
             participation in this trial and adherence to the protocol guidelines difficult should
             be excluded.

          -  Patients with an active psychiatric or mental illness making informed consent or
             careful clinical follow-up unlikely are excluded.

          -  Ejection fraction ≥ 45%

          -  Creatinine<2.0 times upper limit of normal

          -  Total bilirubin < 1.5 times upper limit of normal except for known conjugation
             diseases such as Gilbert's, ALT and AST <3.0 times upper limit of normal. Direct
             bilirubin is not an inclusion criteria.

          -  ECOG performance status of 0, 1, 2

          -  Non pregnant and non lactating Female patients who:

               -  Are postmenopausal for at least 1 year before the screening visit, OR

               -  Are surgically sterile, OR

               -  If they are of childbearing potential, agree to practice 2 effective methods of
                  contraception, at the same time, from the time of signing the informed consent
                  form through 90 days after the last dose of study drug, AND

               -  Must also adhere to the guidelines of any treatment-specific pregnancy prevention
                  program, if applicable, OR

               -  Agree to practice true abstinence when this is in line with the preferred and
                  usual lifestyle of the subject. (Periodic abstinence [eg, calendar, ovulation,
                  symptothermal, post-ovulation methods] and withdrawal are not acceptable methods
                  of contraception.)

          -  Male patients, even if surgically sterilized (i.e., status post-vasectomy), must agree
             to one of the following:

               -  Agree to practice effective barrier contraception during the entire study
                  treatment period and through 90 days after the last dose of study drug, OR

               -  Must also adhere to the guidelines of any treatment-specific pregnancy prevention
                  program, if applicable, OR

               -  Agree to practice true abstinence when this is in line with the preferred and
                  usual lifestyle of the subject. (Periodic abstinence (eg, calendar, ovulation,
                  symptothermal, post-ovulation methods] and withdrawal are not acceptable methods
                  of contraception.)

        Exclusion Criteria:

          -  Patients meeting any of the following exclusion criteria are not to be enrolled in the
             study.

          -  Female patients who are lactating or have a positive serum pregnancy test during the
             screening period.

          -  Major surgery within 14 days before enrollment. Biopsies and line placement procedures
             are not exclusion criteria.

          -  Radiotherapy within 14 days before enrollment. Radiotherapy is excluded during
             induction and consolidation 1 while receiving MLN 9708.

          -  Evidence of current uncontrolled cardiovascular conditions, including uncontrolled
             hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure,
             unstable angina, or myocardial infarction within the past 6 months.

          -  Active hepatitis B or C virus infection, or known human immunodeficiency virus (HIV)
             positive. Hepatitis and HIV testing are not required prior to the start of treatment.

          -  Any serious medical or psychiatric illness that could, in the investigator's opinion,
             potentially interfere with the completion of treatment according to this protocol.

          -  Known allergy to any of the study medications, their analogues, or excipients in the
             various formulations of any agent.

          -  Patient has ≥ Grade 3 peripheral neuropathy, or Grade 2 with pain on clinical
             examination during the screening period.

          -  Known GI disease or GI procedure that could interfere with the oral absorption or
             tolerance of MLN9708 including difficulty swallowing.

          -  Diagnosed or treated for another malignancy within 2 years before study enrollment or
             previously diagnosed with another malignancy and have any evidence of residual
             disease. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are
             not excluded if they have undergone complete resection.

          -  Participation in other clinical trials, including those with other investigational
             agents not included in this trial, within 21days of the start of this trial and
             throughout induction and consolidation 1 portions of this trial (while on MLN 9708).
             Patients may enroll in transplant and post transplant studies after consolidation 1
             treatment (See Section 6.5).

          -  Systemic treatment, within 14 days before the first dose of MLN9708, with strong
             inhibitors of CYP1A2 (fluvoxamine, enoxacin), strong inhibitors of CYP3A
             (clarithromycin, telithromycin, itraconazole, voriconazole, ketoconazole, nefazodone,
             posaconazole) or strong CYP3A inducers (rifampin, rifapentine, rifabutin,
             carbamazepine, phenytoin, phenobarbital), or use of Ginkgo biloba or St. John's wort.
             Ciprofloxocin should not be administered for at least 2 days before MLN 9708
             administration. Extended release ciprofloxocin should not be administered for at least
             3 days prior to MLN 9708 administration.