Inclusion Criteria:

          -  Females of all races with clinical stage I, II, or III ER-positive, HER2 negative
             breast cancer who will undergo SoC neoadjuvant treatment.

          -  Age 18 years and older.

          -  ECOG Performance Status 0 or 1.

          -  White blood cell (WBC) count ≥ 3,000/mm3 within 3 weeks prior to registration.

          -  Platelet count ≥ 100,000/mm3 within 3 weeks prior to registration.

          -  Bilirubin ≤ 2 x institutional upper limit (IUL) of normal obtained within 3 weeks
             prior to registration.

          -  Serum glutamic-oxaloacetic transaminase (SGOT) or aspartate aminotransferase test
             (AST) ≤ 2 x IUL of normal obtained within 3 weeks prior to registration.

          -  Serum glutamic-pyruvic transaminase (SGPT) or alanine aminotransferase test (ALT) ≤ 2
             x IUL of normal obtained within 3 weeks prior to registration.

          -  Serum creatinine ≤ 1.8 mg/dL obtained within 3 weeks prior to registration.

          -  Must sign an informed consent document approved by the UAMS IRB.

        Exclusion Criteria:

          -  ER-negative, HER2-positive, inflammatory, metastatic, stage IV or recurrent breast
             cancer

          -  Active infection requiring treatment with antibiotics.

          -  Existing diagnosis or history of organic brain syndrome that might preclude
             participation in the full protocol.

          -  Existing diagnosis or history of significant impairment of basal cognitive function
             that might preclude participation in the full protocol.

          -  Other current malignancies. Subjects with prior history at any time of any in situ
             cancer, including lobular carcinoma of the breast in situ, cervical cancer in situ,
             atypical melanocytic hyperplasia or Clark I melanoma in situ or basal or squamous skin
             cancer are eligible, provided they are disease-free at the time of registration.
             Subjects with other malignancies are eligible if they have been continuously disease
             free for ≥ 5 years prior to the time of registration.

          -  Active autoimmune disorders or conditions of immunosuppression; Existing diagnosis or
             history of autoimmune disorders or conditions of immunosuppression that have been in
             remission for less than 6 months

          -  Treatment with corticosteroids, including oral steroids (i.e. prednisone,
             dexamethasone [except when used as an antiemetic in SoC therapy]), continuous use of
             topical steroid creams or ointments or any steroid-containing inhalers. Subjects who
             discontinue the use of these classes of medication for at least 6 weeks prior to
             registration are eligible if, in the judgment of the treating physician, the subject
             is not likely to require these classes of drugs during the treatment period.
             Replacement doses of steroids for subjects with adrenal insufficiency are allowed.

          -  Pregnancy or breastfeeding (due to the unknown effects of peptide/mimotope vaccines on
             a fetus or infant). Women of childbearing potential must have a negative urine
             pregnancy test within 72 hours prior to starting week 1 and must be counseled to use
             an accepted and effective method of contraception (including abstinence) while on
             treatment and for a period of 18 months after completing or discontinuing treatment.
             Accepted methods of contraception include tubal ligation, oral contraceptives, barrier
             methods, IUDs, and abstinence.

          -  Any other significant medical or psychiatric conditions, which, in the opinion of the
             enrolling investigator, may interfere with consent or compliance of the treatment
             regimen.

          -  Enrollment in any other clinical trial using investigational drug products or devices
             prior to first post-surgery study lab. Concurrent enrollment in observational studies
             is allowed.