Inclusion Criteria:

          -  Histologically proven and reviewed well differentiated malignant pancreatic sporadic
             NET Metastatic disease not amenable to surgical resection

          -  All target lesions (lesions measurable and non-measurable according to the RECIST 1.1
             criteria), of a size ≥ 15 mm, twice the spatial resolution of the somatostatin
             receptor scintigraphy (SRS), should be positive (grade of uptake at SRS≥ 2, equal to
             the physiologic liver uptake) within 24 weeks prior to enrollement. Negative target
             lesions are acceptable if below 15mm.

          -  Post first line whatever the type of systemic therapy: cytotoxic chemotherapy or
             everolimus or somatostatine analogs… Only one line of cytotoxic chemotherapy is
             authorized.

          -  Evaluable disease according to RECIST 1.1 criteria (Appendix 2)

          -  Progressing disease within 12 months prior to randomization according to RECIST 1.1
             criteria ;

          -  ECOG performance status 0-2 (appendix 9)

          -  Life expectancy ≥ 6 months as prognosticated by the physician

          -  Age ≥ 18 years, no superior limit

          -  Adequate bone marrow reserve (Hb > 8, neutrophils ≥ 1500/mm³ and platelets
             ≥80.000/mm^3)

          -  Effective contraception in pre-menopausal female and male patients during and for at
             least 6 months post-treatment.

          -  Patient´s signed written informed consent

          -  Ability to comply with the protocol procedures

          -  Ability to take oral medication

          -  Patient affiliated to a social security system or beneficiary of the same.

        Exclusion Criteria:

          -  Large or small cell-poorly differentiated pancreatic neuroendocrine tumor according to
             WHO 2010 classification

          -  Any patient receiving treatment with short-acting Octreotide, which cannot be
             interrupted for 24 h before and 24 h after the administration of
             177Lu-DOTA0-Tyr3-Octreotate, or any patient receiving treatment with Octreotide LAR,
             which cannot be interrupted for at least 6 weeks before the administration of
             177Lu-DOTA0-Tyr3-Octreotate, unless OctreoScan® imaging during continued Octreotide
             treatment is in accordance with the inclusion criteria n°2.

          -  More than one line of cytotoxic chemotherapy (a patient who received the same
             molecules of cytotoxic chemotherapy at several times during therapeutic management is
             considered to have benefit from one single line of cytotoxic chemotherapy)

          -  Prior external beam radiation therapy to more than 25% of the bone marrow

          -  Urinary incontinence

          -  History of prior malignancy, except for cured non-melanoma skin cancer, cured in situ
             cervical carcinoma, or other treated malignancies with no evidence of disease for at
             least five years.

          -  Severe renal (measured GFR according to MDRD <50ml/mn or nephrotic syndrome) or
             hepatic insufficiency (ALT / AST > 2.5 x ULN or ALT/AST >5 x ULN if liver function
             abnormalities are due to the underlying malignancy and/or total serum bilirubin > 2.5
             x ULN)

          -  Serum albumin <3.0 g/dL unless prothrombin time is within the normal range.

          -  Uncontrolled diabetes mellitus as defined by a fasting blood glucose above 2 ULN

          -  Decompensated heart failure (ejection fraction <45%), myocardial infarction, stroke,
             pulmonary embolism or revascularization procedure,unstable angina pectoris,
             uncontrolled cardiac arrhythmia, and clinically significant bradycardia during the
             last 12 months.

          -  Hypertension that cannot be controlled despite medications (>=160/95 mmHg despite
             optimal medical therapy)

          -  Abnormal cardiac function with 12 lead ECG. Ongoing cardiac dysrhythmias of NCI CTC
             grade 2, atrial fibrillation of any grade, or prolongation of the QTc interval to >470
             msec for males or >480 msec for females.

          -  Brain metastases (unless these metastases have been treated and stabilized for at
             least 24 weeks, prior to enrolment in the study. Patients with a history of brain
             metastases must have a head CTscan with contrast or MRI to document stable disease
             prior to enrolment in the study.)

          -  Pregnancy or breast feeding (see appendix 6)

          -  Previous treatment with the drugs under study. Prior systemic treatment with any
             tyrosine kinase inhibitors or anti-VEGF angiogenic inhibitors.

          -  Current treatment with another investigational drug.

          -  Treatment with potent CYP3A4 inhibitors and inducers within 7 and 12 days,
             respectively prior to study drug administration.

          -  Prior treatments with chemotherapy or immunotherapy or somatostatine analog therapy
             drug (except in case of functioning syndrome for somatostatine analogue therapy) or
             thoracic radiotherapy within 4 weeks prior to start of treatment

          -  Major surgery for any cause or local radiotherapy within one month prior to start of
             treatment

          -  Liver embolisation therapy within the last 3 months prior start of treatment except if
             progression is demonstrated and embolised lesion not used as targets

          -  Unrecovered toxicity from any kind of therapy

          -  Active or suspected acute or chronic uncontrolled disease that would impart, in the
             judgment of the investigator, excess risk associated with study participation or study
             drug administration,or which, in the judgment of the investigator, would make the
             patient inappropriate for entry into this study