Inclusion Criteria:

        Subjects who are at least 18 years old and are willing and capable of providing informed
        consent. Both men and non-pregnant women will be included.

        HCC diagnosis documented prior to Study Entry by either cytology/histology, CT scan, and
        AFP serum test higher or equal to 30 IU/ml.

        All subjects with reproductive potential are advised to utilize effective contraception
        throughout the course of this study.

        Health score status at baseline. Agreement to participate in the study and to give at least
        3 samples of blood for lab tests.

        Readily available home or o other address where patient can be found. -

        Exclusion Criteria:

        Subjects who might have already taken V5 in prior trials and have no baseline data. Those
        who met inclusion criteria can be retrospectively enrolled. Pregnant or breast-feeding
        women are excluded.

        Subjects who have taken other immunomodulatory therapies within 2 months prior to Entry:
        systemic corticosteroids, immune globulin (IV gamma globulin, IVIG), interferons,
        interleukins, pentoxifylline (Trental), thalidomide, filgrastim (G-CSF), sargramostim
        (GM-CSF); dinitrochlorobenzene (DNCB), thymosin alpha 1 (thymosin alpha), thymopentin,
        inosiplex (Isoprinosine), polyribonucleoside (Ampligen), ditiocarb sodium (Imuthiol), any
        locally available immune modulators, and any other therapeutic or preventive HCC vaccine.
        Subjects requiring concurrent participation in another experimental research treatment
        study, or who received an experimental agent within four weeks prior to Study Entry.

        Evidence of active or acute cardiac disease, epilepsy, or life-threatening diseases
        unrelated to HCC.

        Medical conditions such as active alcohol or substance abuse, or psychological issues that
        in the opinion of the local investigator would interfere with adherence to the requirements
        of this study.

        -