Inclusion Criteria:

          -  Subject has a diagnosis of previously-untreated de novo acute myeloid leukemia (AML)
             according to WHO classification (2008) documented within 28 days prior to enrollment.

          -  Subject has an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.

          -  Subject must meet the following criteria as indicated on the clinical laboratory
             tests.

               -  Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x
                  institutional upper limit normal (ULN)

               -  Total serum bilirubin ≤ 1.5 x institutional ULN

               -  Serum creatinine ≤ 1.5 x institutional ULN or an estimated glomerular filtration
                  rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal
                  Disease (MDRD) equation.

          -  Subject is suitable for oral administration of study drug.

          -  Female subject must be either:

               -  Of non-child bearing potential:

               -  post-menopausal (defined as at least 1 year without any menses) prior to
                  Screening, or

               -  documented surgically sterile or status post hysterectomy (at least 1 month prior
                  to Screening)

               -  Or, if of childbearing potential,

               -  must agree not to try to become pregnant during the study and for 180 days after
                  the final study drug administration, and

               -  must have a negative urine pregnancy test at Screening, and

               -  must use two forms of birth control* (at least one of which must be a barrier
                  method) starting at Screening and throughout the study period and for 180 days
                  after the final study drug administration. *Acceptable forms of birth control
                  include:

                    1. Established use of oral, injected or implanted hormonal methods of
                       contraception.

                    2. Placement of an intrauterine device (IUD) or intrauterine system (IUS).

                    3. Barrier methods of contraception: condom or occlusive cap (diaphragm or
                       cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.

          -  Female subject must not be breastfeeding at Screening or during the study period, and
             for 60 days after the final study drug administration.

          -  Female subject must not donate ova starting at Screening and throughout the study
             period, and for 180 days after the final study drug administration.

          -  Male subject and their female spouse/partners who are of childbearing potential must
             be using highly effective contraception consisting of two forms of birth control* (one
             of which must be a barrier method) starting at Screening and continue throughout the
             study period and for 120 days after the final study drug administration.

          -  Male subject must not donate sperm starting at Screening and throughout the study
             period and for 120 days after the final study drug administration.

          -  Subject agrees not to participate in another interventional study while on treatment.

        Exclusion Criteria:

          -  Subject was diagnosed as acute promyelocytic leukemia (APL) or AML with good risk
             cytogenetics; t(8;21), inv(16) or t(16;16). (Subjects with pending cytogenetics that
             require treatment may enroll. Any subject that is found to have good risk cytogenetics
             after initiation of treatment will discontinue ASP2215 and be taken off trial).

          -  Subject has BCR-ABL-positive leukemia (chronic myelogenous leukemia in blast crisis).

          -  Subject has active malignant tumors other than AML or myelodysplastic syndrome (MDS).

          -  Subject has received previous therapy for AML, with the exception of the following:

               -  Emergency leukapheresis;

               -  Emergency treatment for hyperleukocytosis with hydroxyurea for ≤ 10 days;

               -  Preemptive treatment with retinoic acid prior to exclusion of APL ≤ 7 days;

               -  Growth factor or cytokine support;

               -  Steroids for the treatment of hypersensitivity or transfusion reactions.

          -  Subject has clinically active central nervous system leukemia.

          -  Subject has disseminated intravascular coagulation abnormality (DIC).

          -  Subject has had major surgery within 4 weeks prior to the first study dose.

          -  Subject has radiation therapy within 4 weeks prior to the first study dose.

          -  Subject has congestive heart failure New York Heart Association (NYHA) class 3 or 4,
             or subject with a history of congestive heart failure NYHA class 3 or 4 in the past,
             unless a screening echocardiogram performed within 3 months prior to study entry
             results in a left ventricular ejection fraction that is ≥ 45%.

          -  Subject requires treatment with concomitant drugs that are strong inducers of
             cytochrome P450 (CYP)3A.

          -  Subject requires treatment with concomitant drugs that are strong inhibitors or
             inducers of P glycoprotein (P-gp) with the exception of drugs that are considered
             absolutely essential for the care of the subject.

          -  Subject requires treatment with concomitant drugs that target serotonin 5HT1R or
             5HT2BR receptors or sigma nonspecific receptor with the exception of drugs that are
             considered absolutely essential for the care of the subject.

          -  Subject has an active uncontrolled infection.

          -  Subject is known to have human immunodeficiency virus infection.

          -  Subject has active hepatitis B or C, or other active hepatic disorder.

          -  Subject has any condition which makes the subject unsuitable for study participation
             (e.g. ophthalmic conditions such as advanced cataracts).

          -  Subject has Fridericia-corrected QT interval (QTcF) > 450 ms at Screening based on
             central reading.

          -  Subject has Long corrected QT interval (QTc) Syndrome at Screening.

          -  Subject has hypokalemia and hypomagnesemia at Screening (defined as values below
             institutional lower limit of normal [LLN]).