Inclusion Criteria:

          -  Age ≥ 18 years at the day of consenting to the study

          -  Patients must have histologically confirmed diagnosis of localized GIST with
             documented KIT (CD117) positivity (by polyclonal DAKO antibody staining)

          -  Documented macroscopically complete surgical R0 or R1 resection of primary GIST lesion
             with no evidence of residual lesions or metastases on the baseline CT-scan or MRI
             performed no more than 4 weeks before randomization.

          -  Risk of tumor recurrence ≥ 35% according to National Comprehensive Cancer Network Task
             Force on GIST (NCCN) risk classification (Demetri et al., 2010) (See Appendix 1)

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2

          -  Patients must be under imatinib treatment (at 300 or 400 mg/day) initiated immediately
             after resection and maintained for 3 years (i.e. 36 months ± 3 months at the time of
             randomization) with no more than 3 consecutive months or 6 months in total of
             interruption during these past 3 years.

          -  Patients must have normal organ and bone marrow function at baseline as defined below:

               -  absolute neutrophil count (ANC) ≥ 1.5 G/L, platelet count ≥ 100 G/L, and
                  haemoglobin of ≥ 9 g/dL).

               -  Serum total bilirubin ≤ 1.5 (upper limit of normal (ULN), aspartate
                  aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x ULN (or 5 x ULN
                  in case of hepatic metastases at time of reintroduction)

               -  Adequate renal function assessed by at least one of the following:

                    -  1) Serum creatinine ≤ 1.5 x ULN or

                    -  2) creatinine clearance estimate ≥ 50 mL/min (as calculated according to
                       Cockcroft-Gault formula or MDRD formula for patients > 65 years).

          -  Recovered from prior anti-neoplasia treatment-related toxicity (persistent
             treatment-related toxicity < Grade 2 as per Common Toxicity Criteria for Adverse
             Effects (CTCAE) v4 are accepted)

          -  Women of childbearing potential are required to have a negative serum pregnancy test
             within 72 hours prior to randomization. A positive urine test must be confirmed by a
             serum pregnancy test

          -  Patient must use effective contraception at least 4 weeks prior to study entry, during
             the study participation and for at least 30 days post-treatment (not applicable for
             women of non-childbearing potential)

          -  Ability to understand and willingness for follow-up visits.

          -  Covered by a medical insurance.

          -  Signed and dated informed consent document indicating that the patient has been
             informed of all aspects of the trial prior to enrolment.

        Exclusion Criteria:

          -  Pregnant or breastfeeding women

          -  Patient concurrently using other approved or investigational antineoplastic agents

          -  Any contra-indication to imatinib treatment as per Glivec® SPC

          -  Patient with GIST harboring the mutation D842V in PDGFRA

          -  Major concurrent disease affecting cardiovascular system, liver, kidneys,
             haematopoietic system or else considered as clinically important by the investigator
             and that could be incompatible with patient's participation in this trial or would
             likely interfere with study procedures or results.

          -  Prior history of other malignancies other than study disease (except for basal cell or
             squamous cell carcinoma of the skin or carcinoma in situ of the cervix) unless the
             patient has been free of the disease for at least 3 years.

          -  Patient receiving concurrent treatment with warfarin (acceptable alternative:
             low-molecular weight heparin) or any prohibited concomitant and/or concurrent
             medications

          -  Patient with Grade III/IV cardiac problems as defined by the New York Heart
             Association Criteria. (i.e., congestive heart failure, myocardial infarction within 6
             months of study)

          -  Patient has a known diagnosis of human immunodeficiency virus (HIV) infection.

          -  Major surgery within 2 weeks prior to study entry