Clinical Trials /

Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid Cancer

NCT02289144

Description:

This is an, open-label, protocol designed to evaluate the activity of targeted therapy in anaplastic/undifferentiated thyroid cancer. Arm A will evaluate ATC/UTC with mutations or rearrangements detected in the ALK gene. There is no effective treatment for anaplastic thyroid cancer in the locally recurrent or metastatic setting. Ceritinib will be administered to the patient until disease progression by RECIST 1.1, unacceptable toxicity, withdrawal of consent, or discontinuation of the trial for any other reason. The primary focus of this arm of the protocol is identifying ceritinib's activity in anaplastic or undifferentiated thyroid cancer patients. Those patients with mutations identified in their ALK gene by sequencing their tumor samples, or with the established ALK abnormalities will be treated with ALK-inhibitors. These include the Ventana assay and Vysis FISH probe, and patients with tumors positive by this assay will also be considered eligible for therapy on the trial. Therapeutic Portion: ARM A: ALK Abnormality IND Ceritinib 750 mg orally daily on Day 1 Continue q4 weeks x 2 cycles Primary Endpoint: The development of progression; new recurrence or distant metastasis, as well as enlargement of an existing metastasis on radiographic imaging. Secondary Endpoints: 1. Overall response rate for patients treated with ceritinib as part of the study. 2. Death of study participant due to any cause.

Related Conditions:
  • Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
Recruiting Status:

Recruiting

Phase:

Phase 2

Trial Eligibility

Document

Title

  • Brief Title: Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid Cancer
  • Official Title: Ceritinib in Mutation and Oncogene Directed Therapy in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

Clinical Trial IDs

  • ORG STUDY ID: STU 082014-029
  • NCT ID: NCT02289144

Conditions

  • Metastatic Anaplastic Thyroid Cancer
  • Locally Advanced Anaplastic, Undifferentiated Thyroid Cancer

Interventions

DrugSynonymsArms
CeritinibCeritinib

Purpose

This is an, open-label, protocol designed to evaluate the activity of targeted therapy in anaplastic/undifferentiated thyroid cancer. Arm A will evaluate ATC/UTC with mutations or rearrangements detected in the ALK gene. There is no effective treatment for anaplastic thyroid cancer in the locally recurrent or metastatic setting. Ceritinib will be administered to the patient until disease progression by RECIST 1.1, unacceptable toxicity, withdrawal of consent, or discontinuation of the trial for any other reason. The primary focus of this arm of the protocol is identifying ceritinib's activity in anaplastic or undifferentiated thyroid cancer patients. Those patients with mutations identified in their ALK gene by sequencing their tumor samples, or with the established ALK abnormalities will be treated with ALK-inhibitors. These include the Ventana assay and Vysis FISH probe, and patients with tumors positive by this assay will also be considered eligible for therapy on the trial. Therapeutic Portion: ARM A: ALK Abnormality IND Ceritinib 750 mg orally daily on Day 1 Continue q4 weeks x 2 cycles Primary Endpoint: The development of progression; new recurrence or distant metastasis, as well as enlargement of an existing metastasis on radiographic imaging. Secondary Endpoints: 1. Overall response rate for patients treated with ceritinib as part of the study. 2. Death of study participant due to any cause.

Detailed Description

      This is an, open-label, protocol designed to evaluate the activity of targeted therapy in
      anaplastic/undifferentiated thyroid cancer. Arm A will evaluate ATC/UTC with mutations or
      rearrangements detected in the ALK gene.

      There is no effective treatment for anaplastic thyroid cancer in the locally recurrent or
      metastatic setting. Ceritinib will be administered to the patient until disease progression
      by RECIST 1.1, unacceptable toxicity, withdrawal of consent, or discontinuation of the trial
      for any other reason.

      The primary focus of this arm of the protocol is identifying ceritinib's activity in
      anaplastic or undifferentiated thyroid cancer patients. Those patients with mutations
      identified in their ALK gene by sequencing their tumor samples, or with the established ALK
      abnormalities will be treated with ALK-inhibitors. These include the Ventana assay and Vysis
      FISH probe, and patients with tumors positive by this assay will also be considered eligible
      for therapy on the trial.

      The goal of this multi-center, multi-arm trial is to measure the impact of treating
      metastatic anaplastic thyroid cancer patients with targeted therapy selected for these
      patients due the presence of a genetic mutation or other aberration. This trial will serve as
      a framework by which new biomarker-drug combinations can be identified and added as new arms.

      Therapeutic Portion:

      ARM A: ALK Abnormality IND Ceritinib 750 mg orally daily on Day 1 Continue q4 weeks x 2
      cycles

      Primary Endpoint: The development of progression; new recurrence or distant metastasis, as
      well as enlargement of an existing metastasis on radiographic imaging. CT scans of the neck,
      chest, abdomen and pelvis will be performed at baseline and every two cycles (cycles are 28
      days long) according to standard of care. Other imaging of these areas such as PET/MRI will
      be allowed if CT cannot be performed. MRI of the brain will be performed at baseline and as
      clinically indicated. Wherever it can be safely given, radiographic contrast agents should be
      given for the imaging studies.

      Secondary Endpoints:

        1. Overall response rate for patients treated with ceritinib as part of the study.

        2. Death of study participant due to any cause.
    

Trial Arms

NameTypeDescriptionInterventions
CeritinibExperimental
  • Ceritinib

Eligibility Criteria

        Inclusion Criteria:

          1. Histologically or cytologically confirmed diagnosis of anaplastic thyroid cancer or
             undifferentiated thyroid cancer that demonstrates mutation in the ALK gene as assessed
             by sequencing of the tumor specimen for Arm A. Other ALK abnormalities as detected by
             the approved FISH test (Abbott Molecular Inc), using Vysis breakapart probes (defined
             as 15% or more positive tumor cells); or the Ventana IHC test will also be seen as
             evidence of ALK abnormality and meeting eligibility requirement.

          2. Patients will not have any other curative therapeutic option, such as radiation or
             surgery.

          3. WHO performance status 0-2.

          4. Age greater then or equal to 18 years.

          5. Patients must have recovered from all toxicities related to prior anticancer therapies
             to ≤ Grade 2 (CTCAE v 4.03), provided that any concomitant medication is given prior
             to initiation of treatment with ceritinib. Exception to this criterion: patients with
             any grade of alopecia are allowed to enter the treatment.

          6. Adequate organ function: the following laboratory criteria have been met:

               -  Absolute neutrophil count (ANC) greater then or equal to 1.5 x 109/L

               -  Hemoglobin (Hgb) ≥ 8 g/dL

               -  Platelets greater then or equal to 75 x 109/L

               -  Serum total bilirubin ≤ 1.5 x upper limit of normal (ULN), except for patients
                  with Gilbert's syndrome who may be included if total bilirubin ≤ 3.0 x ULN and
                  direct bilirubin ≤ 1.5 x ULN

               -  Aspartate transaminase (AST) < 2.0 x ULN, except for patients with liver
                  metastasis, who are only included if AST < 3 x ULN; alanine transaminase (ALT) <
                  2.0 x ULN, except for patients with liver metastasis, who are only included if
                  ALT < 3 x ULN

               -  Calculated or measured creatinine clearance (CrCL) less then or equal to 30
                  mL/min

          7. Patient must have the following laboratory values or have the following laboratory
             values corrected with supplements to be within normal limits at screening:

               -  Potassium ≥ LLN

               -  Magnesium ≥ LLN

               -  Phosphorus ≥ LLN

               -  Total calcium (corrected for serum albumin) ≥ LLN

          8. Written informed consent for the protocol must be obtained prior to any screening
             procedures.

          9. Willingness and ability to comply with scheduled visits, treatment plans, laboratory
             tests and other procedures.

        Exclusion Criteria:

          -  Patients eligible must not meet any of the following criteria:

               1. Patients with known hypersensitivity to any of the excipients of ceritinib
                  (microcrystalline cellulose, mannitol, crospovidone, colloidal silicon dioxide
                  and magnesium stearate).

               2. Patients with symptomatic CNS metastases who are neurologically unstable or have
                  required increasing doses of steroids within the 1 week prior to study entry to
                  manage CNS symptoms.

               3. Prior therapy with ceritinib.

               4. Presence or history of a malignant disease other than thyroid cancer that has
                  been diagnosed and/or required therapy within the past year and is undergoing
                  active anticancer treatment. Exceptions to this exclusion include the following:
                  completely resected basal cell and squamous cell skin cancers, and completely
                  resected carcinoma in situ of any type.

               5. Patients with known history of extensive disseminated bilateral interstitial
                  fibrosis or interstitial lung disease, including a history of pneumonitis,
                  hypersensitivity pneumonitis, interstitial pneumonia, obliterative bronchiolitis,
                  and clinically significant radiation pneumonitis (i.e. affecting activities of
                  daily living or requiring therapeutic intervention).

               6. Patient has clinically significant, uncontrolled heart disease and/or recent
                  cardiac event (within 6 months), such as:

                    -  unstable angina within 6 months prior to screening;

                    -  myocardial infarction within 6 months prior to screening;

                    -  history of documented congestive heart failure (New York Heart Association
                       functional classification III-IV);

                    -  uncontrolled hypertension defined by a Systolic Blood Pressure (SBP) ≥ 160
                       mm Hg and/or Diastolic Blood Pressure (DBP) ≥ 100 mm Hg, with or without
                       antihypertensive medication

                    -  initiation or adjustment of antihypertensive medication(s) is allowed prior
                       to screening;

                    -  ventricular arrhythmias; supraventricular and nodal arrhythmias not
                       controlled with medication;

                    -  other cardiac arrhythmia not controlled with medication;

                    -  corrected QTc > 450 msec using Fridericia correction on the screening ECG

               7. Impaired GI function or GI disease that may alter absorption of ceritinib or
                  inability to swallow up to five ceritinib capsules daily.

               8. Ongoing GI adverse events > grade 2 (e.g. nausea, vomiting, or diarrhea) at the
                  start of the study.

               9. Receiving medications that meet one of the following criteria and that cannot be
                  discontinued at least 1 week prior to the start of treatment with ceritinib and
                  for the duration of participation (see Appendix 1 Tables):

                    -  Medication with a known risk of prolonging the QT interval or inducing
                       Torsades de Pointes (please refer to
                       http://www.azcert.org/medical-pros/drug-lists/drug-lists.cfm)

                    -  Strong inhibitors or strong inducers of CYP3A4/5 (please refer to
                       http://medicine.iupui.edu/flockhart/table.htm or
                       http://www.druginteractioninfo.org)

                    -  Medications with a low therapeutic index that are primarily metabolized by
                       CYP3A4/5, CYP2C8 and/or CYP2C9 (please refer to
                       http://medicine.iupui.edu/flockhart/table.htm or
                       http://www.druginteractioninfo.org)

                    -  Therapeutic doses of warfarin sodium (Coumadin) or any other
                       coumadin-derived anti-coagulant. Anticoagulants not derived from warfarin
                       are allowed (eg, dabigatran, rivaroxaban, apixaban).

                    -  Unstable or increasing doses of corticosteroids

                    -  enzyme-inducing anticonvulsive agents

                    -  herbal supplements

              10. Pregnant or nursing (lactating) women, where pregnancy is defined as the state of
                  a female after conception and until the termination of gestation, confirmed by a
                  positive hCG laboratory test.

              11. Women of child-bearing potential, defined as all women physiologically capable of
                  becoming pregnant, unless they are using highly effective methods of
                  contraception during dosing and agree to continue for 3 months after the last
                  dose of study treatment. Highly effective contraception methods include:

                    -  Total abstinence (when this is in line with the preferred and usual
                       lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation,
                       symptothermal, post-ovulation methods) and withdrawal are not acceptable
                       methods of contraception.

                    -  Female sterilization (have had surgical bilateral oophorectomy with or
                       without hysterectomy) or tubal ligation at least six weeks before taking
                       study treatment. In case of oophorectomy alone, only when the reproductive
                       status of the woman has been confirmed by follow up hormone level
                       assessment.

                    -  Male sterilization (at least 6 months prior to screening) with the
                       appropriate post-vasectomy documentation of the absence of sperm in the
                       ejaculate. For female subjects on the study the vasectomized male partner
                       should be the sole partner for that subject.

                    -  Combination of any two of the following (a+b or a+c or b+c):

                         1. Use of oral, injected or implanted hormonal methods of contraception or
                            other forms of hormonal contraception that have comparable efficacy
                            (failure rate < 1%), for example hormone vaginal ring or transdermal
                            hormone contraception.

                         2. Placement of an intrauterine device (IUD) or intrauterine system (IUS).

                         3. Barrier methods of contraception: Condom or Occlusive cap (diaphragm or
                            cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal
                            suppository.

                  In case of use of oral contraception, women should have been stable on the same
                  pill for a minimum of 3 months before taking study treatment.

                  Women are considered post-menopausal and not of child bearing potential if they
                  have had 12 months of natural (spontaneous) amenorrhea with an appropriate
                  clinical profile (e.g., age appropriate, history of vasomotor symptoms) or have
                  had surgical bilateral oophorectomy (with or without hysterectomy) or tubal
                  ligation at least six weeks prior to screening. In the case of oophorectomy
                  alone, only when the reproductive status of the woman has been confirmed by
                  follow up hormone level assessment is she considered not of child bearing
                  potential.

              12. Sexually active males unless they agree to use a condom during intercourse while
                  taking drug and agree to continue for 3 months after the last dose of study
                  treatment. Male patients for 3 months should not father a child in this period. A
                  condom is required to be used also by vasectomized men in order to prevent
                  delivery of the drug via seminal fluid.
      
Maximum Eligible Age:N/A
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:Development of Progression
Time Frame:Radiographic Imaging Assessments at Screening and every 56 days until evidence of progression (average 7 months) or unacceptable toxicity, withdrawal of Consent, or discontinuation of the trial for any other reason.
Safety Issue:
Description:Ceritinib will be administered to the patient until disease progression by RECIST (Response Evaluation Criteria In Solid Tumors).

Details

Phase:Phase 2
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:University of Texas Southwestern Medical Center

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