Key Inclusion Criteria:

          1. Have documented CD20+ B-cell malignancy, with active disease not responsive to prior
             therapy, for whom no standard of care options exists, and for whom treatment with an
             anti-CD20 antibody may be appropriate:

          2. NHL patients must have had prior treatment with an anti-CD20 antibody therapy

          3. Must have at least one bi-dimensionally measurable lesion ≥1.5 cm) documented by CT
             scan.

          4. Eastern Cooperative Oncology Group (ECOG) performance status ≤1

          5. Life expectancy of at least 6 months

          6. Adequate bone marrow function documented by:

               1. Platelet counts ≥75 x 10^9/L

               2. Hb level ≥9 g/dL

               3. Absolute neutrophil count (ANC) ≥1 x 10^9/L

          7. Adequate organ function

          8. Willing and able to comply with clinic visits and study-related procedures

          9. Provide signed informed consent

        Key Exclusion Criteria:

          1. Primary central nervous system (CNS) lymphoma or known or suspected CNS involvement by
             non-primary CNS NHL

          2. History of or current relevant CNS pathology

          3. Allogeneic stem cell transplantation

          4. Infection with human immunodeficiency virus (HIV) or chronic infection with hepatitis
             B virus (HBV) or hepatitis C virus (HCV).

          5. Known hypersensitivity to both allopurinol and rasburicase

          6. History of hypersensitivity to any compound in the tetracycline antibiotics group

        The information provided above is not intended to contain all considerations relevant to
        potential participation in a clinical trial therefore not all inclusion/ exclusion criteria
        are listed.