Inclusion Criteria:

          1. Male and female ≥ 8 years of age

          2. Unresectable locally advanced or metastatic histologically confirmed malignancy
             (excluding melanoma V600 mutation) resistant or refractory to standard therapy or for
             which standard therapy does not exist or is not considered appropriate by the
             Investigator and are not eligible to an appropriate ongoing clinical trial. For Hairy
             Cell Leukemia: .patients must have relapsed and/or be refractory HCL candidate for
             treatment after 2 lines of purine analogues treatment.

          3. Patient with BRAF V600 mutation determined by the INCa platforms on the primary and/or
             metastatic lesion in the following pathologies:

               -  NSCLC

               -  Ovarian cancer

               -  Cholangiocarcinoma

               -  Thyroid cancer

               -  Prostatic cancer

               -  Bladder cancer

               -  Sarcoma/GIST

               -  Multiple myeloma

               -  Chronic Lymphocytic Leukemia (CLL)

               -  Hairy cell leukaemia (HCL) (this excludes Hairy Cell Leukemia variant types,
                  marginal zone splenic lymphoma (MZL), splenic red pulp lymphoma (SRPL) patients).

             Or patient with the same or another pre-listed pathology harboring any type of
             activating BRAF alteration determined from outside the INCa platforms network.

          4. Measurable disease according to RECIST 1.1 guidelines for solid tumors with target
             lesion of at least 10 mm and presence of at least one RECIST-measurable lesion outside
             of a previously radiated field or potential palliative irradiation fields,
             International Myeloma Working group Response Criteria for myeloma, IWCLL Chronic
             Lymphocytic Leukemia and clinical/biological parameters for Hairy cell leukaemia
             (Serum M-protein >0.5 g/dL; Urine M-protein >200 mg per 24 hours; Involved FLC level
             >10 mg/dL (>100 mg/L) provided serum FLC ratio is abnormal).

          5. Patients who had received any previous systemic anticancer treatment and/or
             radiotherapy should have recovered from any treatment related toxicity, i.e. ≤ grade1,
             with a mandatory free interval of at least 3 weeks for systemic or radiotherapy
             treatments and at least 5 half-lives for targeted drugs.

          6. Patients who had received any investigational drug are eligible after a 4-week
             wash-out period or a wash-out period equivalent to 5 half-lives of the product,
             depending on the longest period

          7. Adequate hematologic*, renal* and liver function*, as defined by the following
             laboratory values; test performed within 7 days prior to the first dose of
             vemurafenib:

               -  Hemoglobin ≥9 g/dL

               -  Absolute neutrophil count (ANC) ≥1.5 x 10⁹/L

               -  Platelet count ≥100 x 10⁹/L

               -  Serum creatinine ≤1.5 times upper limit of normal (ULN) or creatine clearance
                  (CrCl) >50 mL/min by Cockroft-Gault formula

               -  Aspartate aminotransferase (AST [SGOT]) and alanine aminotransferase (ALT [SGPT])
                  ≤2.5 times ULN (≤5 times ULN if considered due to primary or metastatic liver
                  involvement)

               -  Serum bilirubin ≤1.5 times ULN

               -  Alkaline phosphatase ≤2.5 times ULN (≤5 times ULN if considered due to tumor) *
                  not applicable if biological abnormality(ies) is (are) fully related to the
                  malignant disease itself.

          8. Normal values for calcium, magnesium and potassium levels

          9. Patients able to swallow and retain oral medication (tablet size: 19 mm. Can not be
             chewed or crushed)

         10. ECOG Performance Status of 0 to 2, or Karnofsky scale >50 %

         11. Life expectancy ≥3 months

         12. Potentially reproductive patients must agree to use an effective contraceptive method,
             practice adequate methods of birth control or practice complete abstinence while on
             treatment, beginning 2 weeks before the first dose of investigational product and for
             at least 6 months after the last dose of study drug

         13. Women of childbearing potential must have a negative serum pregnancy test within 14
             days of enrollment and/or urine pregnancy test 72 hours prior to the administration of
             the study drug

         14. Women who are breastfeeding should discontinue nursing prior to the first day of study
             drug and permanently after the last dose

         15. Patients must be affiliated to a Social Security System.

         16. Patient information and written informed consent form signed.

        Exclusion Criteria:

          1. V600 BRAF mutated melanoma patients or colorectal cancer patients

          2. Patient eligible to a clinical trial with an anticancer drug (including vemurafenib)
             targeting the same BRAF molecular alteration in the same type/localization as the
             patient's cancer presentation open to accrual in France. Patient not eligible in this
             trial are still eligible for the AcSé study.

          3. Prior treatment with a BRAF or MEK inhibitor

          4. Major surgery or tumor embolization within 4 weeks and minor surgery within 2 weeks
             prior to the initiation of the study drug

          5. Patients with other concurrent severe and/or uncontrolled medical disease which could
             compromise participation in the study, such as, but not limited to:

               1. Any of the following within the 6 months prior to starting study treatment:
                  myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass
                  graft, or cerebrovascular accident including transient ischemic attack. Ongoing
                  congestive heart failure.

               2. Pulmonary embolism within 30 days prior to first vemurafenib administration

               3. Hypertension not adequately controlled by current medications within 30 days
                  prior to first vemurafenib administration

               4. Congenital long QT syndrome

               5. Ongoing cardiac dysrhythmias of NCI CTCAE Grade ≥2, uncontrolled atrial
                  fibrillation of any grade, or machine-read ECG with QTc interval >460 msec

               6. Spinal cord compression unless treated with the patient attaining good pain
                  control and stable or recovered neurologic function

               7. Carcinomatous meningitis or leptomeningeal disease

               8. Any uncontrolled infection

               9. Other severe acute or chronic medical (including severe gastrointestinal
                  conditions such as diarrhea or ulcer) or psychiatric conditions, or end stage
                  renal disease on hemodialysis or laboratory abnormalities that would impart, in
                  the judgment of the investigator and/or sponsor, excess risk associated with
                  study participation or study drug administration, and which would, therefore,
                  make the patient inappropriate for study entry

          6. For MM, solitary bone or solitary extramedullary plasmacytoma as the only evidence of
             plasma cell dyscrasia

          7. Known hypersensitivity to vemurafenib or another BRAF inhibitor

          8. Concurrent administration of any anti-cancer therapies (e.g., chemotherapy, other
             targeted therapy, experimental drug, etc.) other than those administered in this study

          9. Refractory nausea and vomiting, malabsorption, external biliary shunt or significant
             bowel resection that would preclude adequate absorption.

         10. Patients with significantly altered mental status prohibiting the understanding of the
             study or with psychological, familial, sociological or geographical condition
             potentially hampering compliance with the study protocol and follow-up schedule; those
             conditions should be discussed with the patient before registration in the trial

         11. Individual deprived of liberty or placed under the authority of a tutor.

         12. Unwillingness to practice effective birth control. Pregnant or lactating women