Key Inclusion Criteria:

          1. Patients must be post-menopausal women, as defined in the protocol

          2. 18 years or older

          3. Patients with histological or cytological proven diagnosis of adenocarcinoma of the
             breast with evidence of either locally advanced, inoperable and/or metastatic disease

          4. Part A, B, C: Patients must have received no more than 2 prior chemotherapeutic
             regimens and at least 6 months of prior endocrine therapy

          5. Part D: Patients may have received up to 1 previous line of chemotherapy and must have
             previously received 2 or more lines of endocrine therapy for advanced/metastatic
             breast cancer as a single agent or in combination. Patients must have received
             fulvestrant as one of the previous lines of endocrine therapy and have had documented
             progression while on, or within 1 month after the end of, fulvestrant therapy for
             advanced/metastatic breast cancer. Patients must have received prior treatment with a
             CDK4/6 inhibitor

        Note: This list is not complete. Further inclusion criteria is provided in the protocol
        synopsis.

        Key Exclusion Criteria:

          1. Prior anticancer or investigational drug treatment within the following windows:

               1. Tamoxifen therapy less than 14 days before first dose of study treatment

               2. Part A, B and C: Fulvestrant therapy less than 90 days before first dose of study
                  treatment. Part D: Fulvestrant therapy less than 42 days before first dose of
                  study treatment

               3. Any other anti-cancer endocrine therapy less than 14 days before first dose of
                  study treatment

               4. Any chemotherapy less than 28 days before first dose of study

               5. Any investigational drug therapy less than 28 days or 3 half-lives (whichever is
                  longer) prior to first dose of study treatment

          2. Patients with untreated or symptomatic central nervous system (CNS) metastases

          3. Patients with endometrial disorders, including evidence of endometrial hyperplasia,
             dysfunctional uterine bleeding or cysts

        Note: This list is not complete. Further exclusion criteria is provided in the protocol
        synopsis.