Inclusion Criteria:

          1. Willing and able to provide written informed consent

          2. Histological or cytological documentation of adenocarcinoma of the colon or rectum.

          3. Male or female subjects > 18 years < 70 of age.

          4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

          5. There must be documentation by CT scan, MRI, or intraoperative palpation that the
             patient has evidence of metastases confined to the liver.

          6. The liver metastases must have been assessed by multidisciplinary team including
             hepatic surgeon approved to participate in the study to be unresectable based on at
             least one of the four criteria: 1. All of the liver metastases can not be completed
             resected with negative margins; 2. No ability to preservation of two contiguous
             hepatic segments; 3. No ability to preservation of adequate vascular inflow and
             outflow as well as biliary drainage; 4. Complete resection would require greater than
             70% of the liver parenchyma to be removed.

          7. The colorectal primary tumor or metastatic tumor must be determined to be KRAS (exon 2
             at codon 12 and 13; exon 3 at codon 59 and 61; exon 4 at codon 117 and 146) or NRAS
             (exon 2 at codon 12 and 13; exon 3 at codon 59 and 61; exon 4 at codon 117 and 146)
             mutation-type.

          8. Primary tumor and regional nodes were resected with clear surgical margins or;
             unresected primary tumor with plan to radical resect the primary tumor.

          9. No previous any systemic anticancer therapy for metastatic disease (adjuvant
             chemotherapy for non-metastatic disease is allowed if terminated more than 6 months
             ago).

         10. Adequate bone marrow, hepatic and renal function as assessed by the following
             laboratory requirements conducted within 7 days of starting study treatment:
             Hemoglobin (Hb) ≥ 90g/ L, absolute neutrophil count (ANC) ≥ 1.5×109/ L, platelet count
             ≥ 100×109/ L; Total bilirubin ≤ 1.5×the upper limit of normal (ULN), alanine
             aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 5 ×ULN; Serum creatinine
             ≤1.5×the ULN.

        Exclusion Criteria:

          1. Any evidence of extrahepatic metastases, lymph node (including portal lymph nodes)
             metastases and primary tumor recurrence.

          2. Previous hepatic resection and/or ablation, hepatic arterial infusion therapy,
             radiation therapy to the liver.

          3. Previous or concurrent cancer that is distinct in primary site or histology from
             colorectal cancer within 5 years prior to randomization.

          4. Significant cardiovascular disease including unstable angina or myocardial infarction
             within 6 months before initiating study treatment.

          5. Heart failure grade III/IV (NYHA-classification).

          6. Unresolved toxicity higher than CTCAE v.4.0 Grade 1 attributed to any prior
             therapy/procedure.

          7. Subjects with known allergy to the study drugs or to any of its excipients.

          8. Current or recent (within 4 weeks prior to starting study treatment) treatment of
             another investigational drug or participation in another investigational study.

          9. Breast- feeding or pregnant women

         10. Lack of effective contraception.