Inclusion Criteria:

          1. Patients should be aged ≥18 years at the inclusion,

          2. Patients with histologically confirmed metastatic collecting duct carcinoma (medullary
             accepted),

          3. Available tumor samples for centralized reading by anatomopathologist,

          4. Patients with or without nephrectomy,

          5. At least one measurable lesion as per response evaluation criteria in solid tumors
             version 1.1 (RECIST v1.1),

          6. No prior chemotherapy nor anti-angiogenic drugs ; Prior adjuvant chemotherapy of
             localised disease admitted if it is stopped for more than 12 months at the inclusion
             date.,

          7. No irradiation within 4 weeks before inclusion,

          8. Absolute neutrophil counts (ANC) ≥1.5 x 10⁹/L,

          9. Platelets ≥100 x 10⁹/L,

         10. Hemoglobin ≥9 g/dL,

         11. Hepatic function : AST and ALT ≤1.5 x ULN (≤4 x ULN in case of liver metastases);
             total bilirubin ≤1.5 x ULN; alkaline phosphatase <2 x ULN (≤4 x ULN in case of bone
             metastases),

         12. Renal function : creatinine clearance ≥60 mL/min (MDRD calculation method) using
             cis-platin and >30 mL/min when using carboplatin,

         13. Absence of proteinuria at baseline defined by <0.3 g of protein on urine sample or
             <0.5 g/24h on urine collection,

         14. Prothrombin time (TP) or partial thromboplastin time (PTT) strictly less than 50%
             deviation from normal limits, of international normalized ratio (INR) strictly below
             2, Note: The use of full-dose oral or parenteral anticoagulants as well as aspirin or
             clopidogrel is permitted as long as the INR or a PTT is within therapeutic limits
             (according to the medical standard of the institution) and the patient has been on a
             stable dose of anticoagulants for at least two weeks at the time of study enrolment.
             Prophylactic use of anticoagulants is allowed.

         15. ECG with normal or clinically insignificant as per investigator's judgement sinus
             rhythm,

         16. ECOG Performance Status: 0 - 2,

         17. Estimated life expectancy ≥12 weeks,

         18. Patients who have received the information sheet, dated and signed the informed
             consent form,

         19. Patient of child-bearing potential (for female patient: study entry after a menstrual
             period and a negative pregnancy test) must agree to use two medically acceptable
             methods of contraception (one for the patient and one for the partner) during the
             study and for 6 months after the last study treatment intake.

         20. Patients must be willing and able to comply with scheduled visits, treatment plan,
             laboratory tests and other study procedures,

         21. Patients affiliated to the Social Security System,

        Exclusion Criteria:

          1. Treatment with any other investigational agent, or participation in another clinical
             trial within 28 days prior to enrolment,

          2. Prior systemic treatment with chemotherapy or anti-angiogenic tyrosine kinase
             inhibitors such as axitinib, sunitinib, sorafenib, pazopanib, tivozanib, mTOR
             inhibitor (Temsirolimus or everolimus) and targeted VEGF drugs such as bevacizumab and
             VEGF trap,

          3. Evidence of current spinal cord compression or leptomeningeal disease. Please note
             that patients with asymptomatic brain metastases are eligible,

          4. Another histological type of renal cancer

          5. Other malignancy within 3 years prior to inclusion (except basal cell carcinoma of the
             skin and/or in situ carcinoma of the cervix, and/or pT1/a bladder cancer),

          6. Uncontrolled hypertension (≥160 mm Hg systolic and/or ≥90 mm Hg diastolic) while
             receiving medication,

          7. Cardio-vascular disorders: congestive heart failure ≥ NYHA II, myocardial infarction
             or coronary artery bypass graft in the previous six months, ongoing severe or unstable
             angina,

          8. LVEF value strictly less than 50%,

          9. Current or recent (within 2 weeks of study enrolment) initiation of aspirin,
             clopidogrel), oral or parenteral anticoagulants or thrombolytic agents for therapeutic
             purposes,

         10. History of clinically significant hemorrhagic or thromboembolic events in the past six
             months, or known inherited predisposition to bleeding or thrombosis or History of
             abdominal fistula, GI perforation, intra-abdominal abscess or active GI bleeding
             within 6 months prior to the first study treatment; History of haemoptysis ≥ grade 2
             (defined as ≥2.5 mL bright red blood per episode) within 1 month of study enrolment,

         11. Patients who underwent, according to the investigator, a significant surgery such as
             but not limited to , abdominal, thoracic or neurologic surgery within 28 days before
             the first treatment administration or patient with a wound that is not already healed
             at the first treatment administration or patients who underwent a minor surgical
             procedure including placement of a vascular access device, within 2 days of the first
             study treatment,

         12. Patients with active gastro-duodenal ulcer,

         13. Patients with untreated bone fracture,

         14. Peripheral neuropathy grade ≥2 (Toxicity Criteria-(CTCAE) v4.0),

         15. Patients with active infection requiring intravenous antibiotics at the time of first
             study treatment,

         16. In the opinion of the investigator, any evidence of other severe or uncontrolled
             systemic disease (e.g. unstable or uncompensated respiratory, cardiac, hepatic or
             renal disease), or any other acute or chronic medical condition that would make the
             patient inappropriate with this study,

         17. Immunocompromised patients, including known seropositivity for human immunodeficiency
             virus (HIV),

         18. Known hypersensitivity to any component of the investigational drugs or excipients,

         19. Pregnant or lactating women,

         20. Person deprived of their liberty or under judicial protection (including
             guardianship),

         21. Patients with significantly altered mental status prohibiting the understanding of the
             study or with psychological, familial, sociological or geographical condition
             potentially hampering compliance with the study protocol and follow-up schedule or any
             condition which, in the opinion of the investigator, would preclude participation in
             this trial. Those conditions should be discussed with the patient before registration
             in the trial.