Inclusion Criteria:

          1. ≥18 years of age.

          2. Signed written informed consent.

          3. Histologically confirmed cutaneous melanoma that is either Stage IIIC (unresectable)
             or Stage IV (metastatic), and determined to be BRAF V600E/K mutation-positive as
             determined by a BRAF mutation assay.

             Note: For Stage IIIC disease, the decision that the disease is unresectable should be
             formally endorsed by the melanoma multidisciplinary tumour board of the local
             institution.

          4. Have received dabrafenib and trametinib for 2 weeks or more prior to enrolment in the
             study (i.e. first fraction of palliative RT), and is still continuing with dabrafenib
             and trametinib.

          5. Symptomatic or bulky (greater than 2 cm in diameter) soft tissue, nodal or bony
             metastases requiring palliative RT.

          6. Have measurable disease according to RECIST 1.1 criteria. Note: patients with bony
             metastases that are not measurable by RECIST 1.1 criteria are allowed in this study.

          7. All anti-cancer treatment-related toxicities (except alopecia and laboratory values as
             listed on Table 1 in protocol) must be less than or equal to (≤) Grade 1 according to
             the Common Terminology Criteria for Adverse Events version 4 (CTCAE version 4.03; NCI,
             2009) at the time of study enrolment.

          8. Able to swallow and retain oral medication and must not have any clinically
             significant gastrointestinal abnormalities that may alter absorption such as
             malabsorption syndrome or major resection of the stomach or bowels.

          9. Women of childbearing potential must have a negative serum pregnancy test within 7
             days prior to enrolment and agree to use effective contraception, from 14 days prior
             to enrolment throughout the treatment period, and for 4 months after the last dose of
             study treatment.

         10. An Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

         11. Adequate baseline organ function (as defined in Table 1 in protocol).

        Exclusion Criteria:

          1. Treatment with Ipilimumab or any other anti-CTLA-4 monoclonal antibody therapy within
             the past 4 weeks.

          2. Treatment with anti-PD-1 or anti-PD-L1 monoclonal antibody therapy within the past 4
             weeks.

          3. Known ocular or primary mucosal melanoma.

          4. Four (4) or more lesions requiring palliative RT at the time of study enrolment.

          5. Symptomatic brain metastases or those treated < 3 months previously.

          6. Clear evidence of systemic disease progression on dabrafenib and trametinib.

          7. Systemic anti-cancer treatment (chemotherapy, immunotherapy, biologic therapy, vaccine
             therapy, or investigational treatment) within the last 4 weeks. Prior interferon
             treatment in the adjuvant setting is allowed.

             Note: Tamoxifen and aromatase inhibitors are allowed in the adjuvant setting of breast
             cancer.

          8. Current use of a prohibited medication (list of prohibited medications in protocol).

          9. History of malignancy other than disease under study within 3 years of study enrolment
             with exceptions below, or any malignancy with confirmed activating RAS mutation.

             Note: Prospective RAS testing is not required. However, if the results of previous RAS
             testing are known, they must be used in assessing eligibility.

             Exception: Subjects who have been disease-free for 3 years, or subjects with a history
             of completely resected non-melanoma skin cancer.

         10. Any serious or unstable pre-existing medical conditions (aside from malignancy
             exceptions specified above), psychiatric disorders, or other conditions that could
             interfere with the subject's safety, obtaining informed consent, or compliance with
             study procedures.

         11. A history of known Human Immunodeficiency Virus (HIV).

         12. A history or evidence of cardiovascular risk including any of the following:

               -  A QT interval corrected for heart rate using the Bazett's formula (QTcB) ≥ 480
                  msec;

               -  A history or evidence of current clinically significant uncontrolled arrhythmias;

               -  A history of acute coronary syndromes (including myocardial infarction or
                  unstable angina), coronary angioplasty, or stenting within 6 months prior to
                  enrolment;

               -  A history or evidence of current ≥ Class II congestive heart failure as defined
                  by the New York Heart Association (NYHA) guidelines;

               -  Patients with intra-cardiac defibrillators;

               -  Abnormal cardiac valve morphology (≥ grade 2) documented by echocardiogram
                  (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis] can be
                  entered on study). Subjects with moderate valvular thickening should not be
                  entered on study; g. Treatment refractory hypertension defined as a blood
                  pressure of systolic> 140 mmHg and/or diastolic > 90 mm Hg which cannot be
                  controlled by anti-hypertensive therapy; h. Known cardiac metastases.

         13. A history of retinal vein occlusion (RVO).

         14. Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs
             chemically related to the study treatments, their excipients, and/or dimethyl
             sulfoxide (DMSO).

         15. Pregnant or nursing females.

         16. Previous RT to the same lesion or area due to receive the current course of palliative
             RT.

             Note: patients who had previous RT to other areas are eligible to the study if the
             previous RT was completed more than 8 weeks prior.

         17. A history of autoimmune diseases which are known to increase radiation toxicity,
             including systemic lupus erythematosus and scleroderma.

         18. Genetic syndromes exhibiting increased radiosensitivity (e.g. ataxia telangiectasia).