Clinical Trials /

MPDL3280A and Stereotactic Ablative Radiotherapy in Patients With Non-small Cell Lung Cancer

NCT02400814

Description:

This pilot phase I trial compares administration schedules of anti-programmed cell death-1 ligand 1 (PD-L1) monoclonal antibody MPDL3280A and stereotactic ablative radiotherapy in treating patients with stage IV non-small cell lung cancer. Monoclonal antibodies, such as anti-PD-L1 monoclonal antibody MPDL3280A, may block tumor growth in different ways by targeting certain cells. Stereotactic ablative radiotherapy, also known as stereotactic body radiation therapy, is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. Giving anti-PD-L1 monoclonal antibody MPDL3280A with stereotactic ablative radiotherapy may be a better treatment for non-small cell lung cancer. However, it is not yet known what the best administration schedule is for these treatments.

Related Conditions:
  • Non-Small Cell Lung Carcinoma
Recruiting Status:

Active, not recruiting

Phase:

Phase 1

Trial Eligibility

Document

Title

  • Brief Title: MPDL3280A and Stereotactic Ablative Radiotherapy in Patients With Non-small Cell Lung Cancer
  • Official Title: Pilot Study of MPDL3280A Plus Stereotactic Ablative Radiotherapy (SAR) in Stage IV Non-small Cell Lung Cancer

Clinical Trial IDs

  • ORG STUDY ID: 685389
  • SECONDARY ID: UCDCC#251
  • SECONDARY ID: ML29551
  • SECONDARY ID: UCDCC#251
  • SECONDARY ID: P30CA093373
  • SECONDARY ID: NCI-2014-02629
  • NCT ID: NCT02400814

Conditions

  • Recurrent Non-Small Cell Lung Carcinoma
  • Stage IV Non-Small Cell Lung Cancer

Interventions

DrugSynonymsArms
Anti-PD-L1 Monoclonal Antibody MPDL3280AMPDL3280A, RG7446Arm I (concurrent cohort)

Purpose

This pilot phase I trial compares administration schedules of anti-programmed cell death-1 ligand 1 (PD-L1) monoclonal antibody MPDL3280A and stereotactic ablative radiotherapy in treating patients with stage IV non-small cell lung cancer. Monoclonal antibodies, such as anti-PD-L1 monoclonal antibody MPDL3280A, may block tumor growth in different ways by targeting certain cells. Stereotactic ablative radiotherapy, also known as stereotactic body radiation therapy, is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. Giving anti-PD-L1 monoclonal antibody MPDL3280A with stereotactic ablative radiotherapy may be a better treatment for non-small cell lung cancer. However, it is not yet known what the best administration schedule is for these treatments.

Detailed Description

      PRIMARY OBJECTIVES:

      I. To determine which administration schedule of MPDL3280A (anti-PD-L1 monoclonal antibody
      MPDL3280A) and stereotactic ablative radiotherapy (SAR) will be most promising to move
      forward to a phase II trial based on safety and objective response rate.

      SECONDARY OBJECTIVES:

      I. To define the safety and toxicity profile of MPDL3280A plus SAR using Common Terminology
      Criteria for Adverse Events (CTCAE) version 4 (v4).

      II. Radiographic response rates by immure-related Response Evaluation Criteria in Solid
      Tumors (irRECIST).

      III. Progression free survival using Response Evaluation Criteria in Solid Tumors (RECIST)
      1.1 and irRECIST.

      TERTIARY OBJECTIVES:

      I. Conduct correlative immunologic endpoints.

      OUTLINE: Patients are assigned to 1 of 3 arms.

      ARM I (CONCURRENT COHORT): Patients receive anti-PD-L1 monoclonal antibody MPDL3280A
      intravenously (IV) over 30-60 minutes on day 1. Courses repeat every 3 weeks in the absence
      of disease progression or unacceptable toxicity. Beginning on day 1 of course 1, patients
      also undergo SAR 2-3 times per week (with a minimum of 40 hours and a maximum of 96 hours
      between fractions) over 1.5-2 weeks for a total of 5 fractions.

      ARM II (INDUCTION COHORT): Patients receive anti-PD-L1 monoclonal antibody MPDL3280A IV over
      30-60 minutes on day 1. Courses repeat every 3 weeks in the absence of disease progression or
      unacceptable toxicity. Beginning on day 1 of course 3, patients also undergo SAR 2-3 times
      per week (with a minimum of 40 hours and a maximum of 96 hours between fractions) over 1.5-2
      weeks for a total of 5 fractions.

      ARM III (SEQUENTIAL COHORT): Patients undergo SAR 2-3 times per week (with a minimum of 40
      hours and a maximum of 96 hours between fractions) over 1.5-2 weeks for a total of 5
      fractions beginning on day 1 of course 1. After completion of SAR (beginning on day 1 of
      course 2), patients receive anti-PD-L1 monoclonal antibody MPDL3280A IV over 30-60 minutes on
      day 1. Courses repeat every 3 weeks in the absence of disease progression or unacceptable
      toxicity.

      After completion of study treatment, patients are followed up for 30 days.
    

Trial Arms

NameTypeDescriptionInterventions
Arm I (concurrent cohort)ExperimentalPatients receive anti-PD-L1 monoclonal antibody MPDL3280A IV over 30-60 minutes on day 1. Courses repeat every 3 weeks in the absence of disease progression or unacceptable toxicity. Beginning on day 1 of course 1, patients also undergo SAR 2-3 times per week (with a minimum of 40 hours and a maximum of 96 hours between fractions) over 1.5-2 weeks for a total of 5 fractions.
  • Anti-PD-L1 Monoclonal Antibody MPDL3280A
Arm II (induction cohort)ExperimentalPatients receive anti-PD-L1 monoclonal antibody MPDL3280A IV over 30-60 minutes on day 1. Courses repeat every 3 weeks in the absence of disease progression or unacceptable toxicity. Beginning on day 1 of course 3, patients also undergo SAR 2-3 times per week (with a minimum of 40 hours and a maximum of 96 hours between fractions) over 1.5-2 weeks for a total of 5 fractions.
  • Anti-PD-L1 Monoclonal Antibody MPDL3280A
Arm III (sequential cohort)ExperimentalPatients undergo SAR 2-3 times per week (with a minimum of 40 hours and a maximum of 96 hours between fractions) over 1.5-2 weeks for a total of 5 fractions beginning on day 1 of course 1. After completion of SAR (beginning on day 1 of course 2), patients receive anti-PD-L1 monoclonal antibody MPDL3280A IV over 30-60 minutes on day 1. Courses repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.
  • Anti-PD-L1 Monoclonal Antibody MPDL3280A

Eligibility Criteria

        Inclusion Criteria:

          -  Signed informed consent

          -  Ability to comply with the protocol

          -  Adults with histologically proven stage IV non-small cell lung cancer

          -  At least two sites of measurable disease as defined by RECIST 1.1; one of which must
             be amenable to treatment with SAR and accessible for optional pre- and post- treatment
             biopsy; if a pulmonary nodule is being considered for SAR it must range in size from
             1-3 cm

          -  Have provided written consent for mandatory pre- and post-treatment biopsy (expansion
             cohort only)

          -  Patients with treated supratentorial metastases are allowed if stable, the patient is
             off steroids and no evidence of intracranial hemorrhage

          -  Archival tumor sample available; a minimum of 10 unstained slides; no fine needle
             aspiration (FNAs) allowed or tumor tissue from bone

          -  Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

          -  Life expectancy >= 3 months

          -  Absolute neutrophil count (ANC) >= 1500 cells/ul

          -  White blood cell (WBC) count > 2500/uL

          -  Lymphocyte count >= 500/uL

          -  Platelet count >= 100,000/uL

          -  Hemoglobin >= 9 g/dL

          -  Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper
             limit of normal (ULN) with alkaline phosphatase =< 2.5 x ULN OR AST and ALT =< 1.5 x
             ULN, with alkaline phosphatase > 2.5 x ULN

          -  Serum bilirubin =< 1.0 x ULN

          -  International normalized ratio (INR) and activated partial thromboplastin time (aPTT)
             =< 1.5 x ULN (for patients on anticoagulation they must be receiving a stable dose for
             at least 1 week prior to randomization)

          -  Creatinine clearance >= 30 mL/min by Cockcroft-Gault formula

          -  No history of severe hypersensitivity reactions to other monoclonal antibodies (mAbs)

          -  No other active malignancy

          -  No active autoimmune disease or a history of known or suspected autoimmune disease

          -  No chemotherapy or radiotherapy within the past 28 days and patients must have
             recovered any acute toxicity associated with their most recent previous treatment

          -  Any number of prior treatments is allowed; must have failed at least 1 treatment
             regimen for metastatic disease

          -  Female patients of childbearing potential and male patients with partners of
             childbearing potential, agreement (by patient and/or partner) to use highly effective
             form(s) of contraception

        Exclusion Criteria:

          -  Patients whose tumors contain activating epidermal growth factor receptor (EGFR)
             mutations or anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangement should
             be excluded from this study, unless disease has progressed on all available, approved
             therapies targeting the EGFR mutation or ALK rearrangement

          -  Active or untreated central nervous system (CNS) metastases

          -  Leptomeningeal disease

          -  Uncontrolled pleural or pericardial effusion or ascites that would require recurrent
             drainage

          -  Uncontrolled tumor related pain

          -  Uncontrolled hypercalcemia

          -  Pregnant and lactating women

          -  Uncontrolled concomitant disease

          -  Significant cardiovascular disease (New York Heart Association class II or greater);
             myocardial infarction within 3 months prior to enrollment, unstable arrhythmias,
             unstable angina or a patient with a known left ventricular ejection fraction (LVEF) <
             40%

          -  Severe infection within 4 weeks prior to enrollment

          -  Oral or IV antibiotics within 2 weeks prior to enrollment

          -  History of severe allergic, anaphylactic or other hypersensitivity reactions to
             chimeric or humanized antibodies or fusion proteins

          -  Known hypersensitivity or allergy to Chinese hamster ovary cell products or any
             component of the MDPL3280A formulation

          -  History of autoimmune disease including but not limited to myasthenia gravis,
             myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis,
             inflammatory bowel disease, vascular thrombosis associated with antiphospholipid
             syndrome, Wegener's granulomatosis, Sjogren's syndrome, Guillain-Barre syndrome,
             multiple sclerosis, vasculitis, or glomerulonephritis

               -  Patients with a history of autoimmune-related hypothyroidism on a stable dose of
                  thyroid replacement hormone may be eligible

               -  Patients with controlled Type 1 diabetes mellitus on a stable insulin regimen may
                  be eligible

          -  Patients with a prior allogeneic bone marrow transplantation or prior solid organ
             transplantation

          -  History of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced
             pneumonitis, organizing pneumonia (i.e. bronchiolitis obliterans, cryptogenic
             organizing pneumonia), or evidence of active pneumonitis on screening chest computed
             tomography (CT) scan

               -  A history of radiation pneumonitis in the radiation field (fibrosis) is permitted

          -  Positive test for human immunodeficiency virus (HIV)

          -  Patients with active hepatitis B (defined as a positive hepatitis B surface antigen
             [HBsAg] test at screening) or hepatitis C

               -  Patients with past hepatitis B virus infection or resolved hepatitis B virus
                  (HBV) infection (defined as a negative HBSAg test and a positive antibody to
                  hepatitis B core antigen antibody test) are eligible

               -  Patients with a hepatitis C virus (HCV) antibody are eligible only if polymerase
                  chain reaction is negative for HCV ribonucleic acid (RNA)

          -  Active tuberculosis

          -  Administration of a live, attenuated vaccine within 4 weeks prior to enrollment or
             anticipation that such a live attenuated vaccine will be required during the study

          -  Prior treatment with a cluster of differentiation (CD)137 agonists, anti-cytotoxic
             T-lymphocyte-associated protein 4 (CTLA4), anti-programmed cell death 1 (PD-1), or
             anti-PD-L1 therapeutic antibody or pathway targeting agents

          -  Treatment with systemic immunostimulatory agents (including but not limited to
             interferons or interleukin-2) within 4 weeks or five half-lives of the drug, whichever
             is shorter, prior to enrollment

          -  Treatment with systemic corticosteroids or other systemic immunosuppressive
             medications (including but not limited to prednisone, dexamethasone, cyclophosphamide,
             azathioprine, methotrexate, thalidomide, anti-tumor necrosis factor agents) within 2
             weeks prior to enrollment or anticipated requirement for systemic immunosuppressive
             medications during the trial

               -  Patients who have received acute, low dose, systemic immunosuppressant medication
                  (e.g., a one-time dose of dexamethasone for nausea) may be enrolled after a
                  discussion and approval by the principal investigator

               -  The use of inhaled corticosteroids and mineralocorticoids (eg, fludrocortisone)
                  is allowed
      
Maximum Eligible Age:N/A
Minimum Eligible Age:19 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:Incidence of adverse events
Time Frame:Up to 30 days after completion of study treatment
Safety Issue:
Description:Adverse events observed will be summarized in terms of type (organ affected or laboratory determination), severity (by National Cancer Institute CTCAE v4 and nadir or maximum values for the laboratory measures), time of onset (i.e. course number), duration, and reversibility or outcome. Tables will be created to summarize these toxicities and side effects by dose and by course.

Details

Phase:Phase 1
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:University of California, Davis

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