Inclusion Criteria:
1. Understand and voluntarily sign an informed consent document prior to any study
related assessments/procedures are conducted.
2. ≥ 18 years of age or older at the time of signing the informed consent document.
Entry Criteria Specific for Dose-Escalation Phase (Part A)
3. Subjects with CD20 positive, histologically or cytologically-confirmed, diffuse large
B-cell lymphoma (DLBCL)(including transformed low grade lymphoma) who have relapsed or
refractory disease following at least two prior standard treatment regimens (eg,
R-CHOP or similar first-lineregimen and at least one second-line salvage regimen)
and/or autologous stem cell transplant (ASCT) in chemotherapy-sensitive patients, with
the following ASCT
EXCEPTIONS:
- Subjects in the pre-ASCT setting with poor prognosis, defined as primary
refractory disease, that have relapsed within 12 months following first-line
treatment; "double-hit" lymphomas with Bcl-2/Myc gene rearrangements or,
overexpression or high IPI score (2,3) at relapse.
- Subjects refusing ASCT or for whom ASCT is not appropriate based on the
Investigator's judgment.
Entry Criteria Specific for Dose-Expansion Phase (Part B)
4. Subjects with CD20 positive, histologically confirmed (by WHO 2008 classification
[Jaffe, 2009]), FL (Grade 1, 2, or 3a) who have relapsed or refractory disease
following at least one prior standard systemic treatment regimen including systemic
chemo-, immune-, or chemoimmunotherapy.
Systemic therapy includes treatments such as rituximab monotherapy, chemotherapy given
with or without rituximab, radio-immunoconjugates such as 90Y-ibritumomab tiuxetan and
1311-tositumomab. Systemic therapy does not include, for example, H. pylori
eradication or antibiotic treatment.
Lenalidomide naïve
1. Relapsed or refractory follicular lymphoma (Grade 1, 2, or 3a) following at least
one prior standard systemic treatment regimen including systemic chemo-, immune-,
or chemoimmunotherapy with no prior exposure to lenalidomide (FL-1 cohort)
Lenalidomide exposed
2. Relapsed or refractory follicular lymphoma (Grade 1, 2, or 3a) previously treated
with at least two cycles of lenalidomide-containing regimen (FL-2 cohort), either
as a single agent or in combination, and experienced outcomes to the lenalidomide
treatment as follows:
Early relapse after lenalidomide treatment: Subjects with relapse within one year of
last dose of lenalidomide (or a lenalidomide-containing regimen) following initial
response of Complete Response (CR) to lenalidomide (or a lenalidomide-containing
regimen) Early progression after lenalidomide treatment: Subjects with Progressive
Disease (PD) within one year of last dose of lenalidomide (or lenalidomide-containing
regimen) following initial response of partial response (PR) to lenalidomide (or a
lenalidomide-containing regimen) Disease refractory to lenalidomide: Subjects with
best response of stable disease (SD) or PD while on lenalidomide (or
lenalidomide-containing regimen) without any documented response of PR or better
during treatment with lenalidomide (or a lenalidomide-containing regimen) Lenalidomide
or lenalidomide - containing regimen does not need to be the immediate prior regimen
received by the subject to be eligible for entry.
Entry Criteria that apply to both Part A and Part B
5. Subjects with CD20 positive, histologically confirmed (by WHO 2008 classification
[Jaffe, 2009]), FL (Grade 1, 2, or 3a) who have relapsed or refractory disease
following at least one prior standard systemic treatment regimen including systemic
chemo-, immune-, or chemoimmunotherapy.
Systemic therapy includes treatments such as rituximab monotherapy, chemotherapy given
with or without rituximab, radio-immunoconjugates such as 90Y-ibritumomab tiuxetan and
1311-tositumomab. Systemic therapy does not include, for example, H. pylori
eradication or antibiotic treatment.
Lenalidomide naïve
1. Relapsed or refractory follicular lymphoma (Grade 1, 2, or 3a) following at least
one prior standard systemic treatment regimen including systemic chemo-, immune-,
or chemoimmunotherapy with no prior exposure to lenalidomide (FL 2 cohort). In
addition, subjects must have received one prior line of salvage therapy, unless
ineligible for autologous transplant.
Lenalidomide exposed
2. Relapsed or refractory follicular lymphoma (Grade 1, 2, or 3a) previously treated
with at least two cycles of lenalidomide-containing regimen (FL-1 cohort), either
as a single agent or in combination, and experienced outcomes to the lenalidomide
treatment as follows:
Early relapse after lenalidomide treatment: Subjects with relapse within one year of
last dose of lenalidomide (or a lenalidomide-containing regimen) following initial
response of Complete Response (CR) to lenalidomide (or a lenalidomide-containing
regimen) Early progression after lenalidomide treatment: Subjects with Progressive
Disease (PD) within one year of last dose of lenalidomide (or lenalidomide-containing
regimen) following initial response of partial response (PR) to lenalidomide (or a
lenalidomide-containing regimen) Disease refractory to lenalidomide: Subjects with
best response of stable disease (SD) or PD while on lenalidomide (or
lenalidomide-containing regimen) without any documented response of PR or better
during treatment with lenalidomide (or a lenalidomide-containing regimen) Lenalidomide
or lenalidomide - containing regimen does not need to be the immediate prior regimen
received by the subject to be eligible for entry.
Entry Criteria that apply to both Part A and Part B
6. Bi-dimensionally measurable disease on cross sectional imaging by Computed Tomagraphy
(CT) or Magnetic resonance imaging (MRI) with at least one lesion > 1.5 cm in the
transverse diameter, as defined by the International Working Group (IWG) NHL criteria
Measurable disease cannot be previously irradiated.
7. ECOG PS (Eastern Cooperative Oncology Group Scale of Performance Status) of 0 to 1.
8. Subjects must have the following laboratory values at screening:
- Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L without growth factor support for 7
days (14 days if subject received pegfilgrastim).
- Hemoglobin (Hgb) ≥ 8 g/dL.
- Platelets (plt) ≥ 50 x 109/L without transfusion for 7 days.
- Potassium within normal limits or corrected with supplements.
- Aspartate aminotransferase/Serum glutamic-oxaloacetic transaminase (AST/SGOT) and
Alanine aminotransferase / Serum glutamic pyruvic transaminase (ALT/SGPT) ≤ 2.5 x
Upper Limit of Normal (ULN) or ≤ 5.0 x ULN if liver tumor is present.
- Serum bilirubin ≤1.5 x ULN except in cases of Gilberts Syndrome, then ≤ 2.0 x ULN
- Estimated serum creatinine clearance of ≥ 60 mL/min using the Cockcroft-Gault
equation.
9. Per the Pregnancy Prevention Risk Management Plan (PPRMP)
1. Females of childbearing potential (FCBP) must undergo pregnancy testing based on
the frequency outlined in PPRMP and pregnancy results must be negative.
2. Unless practicing complete abstinence from heterosexual intercourse, sexually
active FCBP must agree to use adequate contraceptive methods as specified in
PPRMP.
Complete abstinence is only acceptable in cases where this is the preferred and
usual lifestyle of the subject.
Periodic abstinence (calendar ovulation, symptothermal, post-ovulation methods)
and withdrawal are not acceptable.
3. Males (including those who have had a vasectomy) must use barrier contraception
(condoms) when engaging in sexual activity with FCBP as specified in PPRMP.
4. Males must agree not to donate semen or sperm for the duration specified in
PPRMP.
5. All subjects must:
Understand that the study drugs could have a potential teratogenic risk. Agree to
abstain from donating blood while taking study drugs and following
discontinuation of investigational product.
Agree not to share study drugs with another person.
6. Other than the subject, FCBP and males able to father a child should not handle
the study drugs or touch the capsules, unless gloves are worn.
7. Be counseled about pregnancy precautions and risks of fetal exposure (refer to
PPRMP, Appendix B)
10. Able to adhere to the study visit schedule and other protocol requirements.
Exclusion Criteria:
1. Any significant medical condition, laboratory abnormality, or psychiatric illness that
would prevent the subject from participating in the study.
2. Any condition including the presence of laboratory abnormalities, which places the
subject at unacceptable risk if he/she were to participate in the study.
3. Any condition that confounds the ability to interpret data from the study.
4. Symptomatic central nervous system involvement.
5. Any history of progressive multifocal leukoencephalopathy (PML).
6. Known symptomatic acute or chronic pancreatitis.
7. Persistent diarrhea or malabsorption ≥ NCI CTCAE Grade 2, despite medical management.
8. Peripheral neuropathy ≥ NCI CTCAE (National Cancer Institute Common Terminology
Criteria for Adverse Events) Grade 2
9. Impaired cardiac function or clinically significant cardiac diseases, including any of
the following:
- LVEF (left ventricular ejection fraction) < 45% as determined by MUGA
(multi-gated acquisition scan) or ECHO (echocardiogram).
- Complete left bundle branch or bifascicular block.
- Congenital long QT syndrome.
- Persistent or clinically meaningful ventricular arrhythmias.
- QTcF > 460 msec on Screening ECG (electrocardiogram) (mean of triplicate
recordings as assessed by central read).
- Unstable angina pectoris or myocardial infarction ≤ 6 months prior to starting
study drugs.
- Troponin T value > 0.4 ng/mL or BNP > 300 pg/mL
- Subjects with baseline troponin T > ULN or BNP > 100 pg/mL are eligible but must
have a cardiologist evaluation prior to enrollment in the trial for baseline
assessment and optimization of cardioprotective therapy.
10. Prior ASCT (autologous stem cell transplant) ≤ 3 months before first dose.
11. Prior allogeneic stem cell transplant with either standard or reduced intensity
conditioning.
12. Prior systemic cancer-directed treatments or investigational modalities ≤ 5 half lives
or 1 month prior to starting study drugs, whichever is shorter
13. Prior radiotherapy within 1 month prior to starting study drugs.
14. A major surgery ≤ 2 weeks prior to starting study drugs. Subjects must have recovered
from any effects of recent surgery or therapy that might confound the safety
evaluation of study drug.
15. Prior treatment with CC-122
16. History of severe allergic or anaphylactic reactions to humanized monoclonal
antibodies.
a. Allergic to any excipients in obinutuzumab.
17. Known human immunodeficiency virus (HIV) infection.
18. Known chronic active hepatitis B or C virus (HBV, HCV) infection.
1. Subjects who are seropositive due to HBV vaccination are eligible.
2. Subjects who have no active viral infection and are under adequate prophylactics
against HBV re-activation are eligible.
19. Need for current chronic systemic corticosteroid therapy (≥ 10 mg of prednisone per
day or an equivalent dose of other anti-inflammatory corticosteroids).
a. Stable use of inhaled corticosteroids is allowed.
20. Treatment-related myelodysplastic syndrome.
21. Prior history of secondary malignancies (except for basal cell or squamous cell
carcinoma of the skin or carcinoma in situ of the cervix or breast) unless the subject
has been free of the disease for ≥ 1 year prior to starting study drugs.
22. Prior immunization with live virus vaccines (within 3 months prior to starting study
drug) or anticipated immunization with live virus vaccines during the duration of the
study.
23. Pregnant or nursing females.
24. Unwilling or unable to comply with the protocol, in the opinion of the Investigator.
